DAY101-001/PNOC026/FIREFLY-1: A Phase 2 Open-Label Multicenter Study to Evaluate the Safety and Efficacy of the Oral Pan-RAF Inhibitor DAY101 in Pediatric Patients with RAF-Altered Recurrent or Progressive Low-Grade Glioma and Advanced Solid Tumors
DAY101 is an oral, selective, small-molecule, Type II pan-RAF kinase inhibitor that is being developed by DOT Therapeutics-1 Inc. (Day One, the Sponsor) for the treatment of recurrent or progressive pediatric low-grade gliomas and pediatric and adult solid tumors which harbor a known or expected to be activating RAF alteration.
DAY101-002; LOGGIC/FIREFLY-2: A Phase 3 Randomized International Multicenter Trial of DAY101 Monotherapy Versus Standard of Care Chemotherapy in Patients With Pediatric Low-Grade Glioma Harboring an Activating RAF Alteration Requiring First-Line Systemic Therapy.
The study is also being done to learn more about how the study drug is absorbed (taken up in the body), metabolized (broken down by the body), distributed (circulated in the body), and eliminated (passed out of the body). The patients will be monitored and taken care of while on these medication during the entire study period.
Deans | NYU Langone Health
The leadership of NYU Langone Health includes our current deans.
Decompression Surgery for Facial Nerve Paralysis | NYU Langone Health
NYU Langone specialists may recommend decompression surgery if a paralyzed facial nerve does not show early signs of recovery.
Deep Brain Stimulation for Anxiety Disorders | NYU Langone Health
NYU Langone doctors may recommend deep brain stimulation for adults with severe obsessive-compulsive disorder.
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NYU Langone doctors may recommend deep brain stimulation for severe depression.
Deep Brain Stimulation for Movement Disorders | NYU Langone Health
NYU doctors perform deep brain stimulation for some people who have severe movement disorders.
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NYU Langone neurologists may recommend deep brain stimulation to manage motor symptoms of Parkinson’s disease that don’t respond to medication.
Deep Brain Stimulation for Tourette Disorder | NYU Langone Health
An experimental treatment called deep brain stimulation may be an option for young adults and adults with severe Tourette disorder symptoms.
Deep learning on ECGs to improve outcomes in patients on dialysis
During hemodialysis, a rapid fluid removal can cause fall in blood pressure. When compensatorymechanisms fail to raise blood pressure, chronic kidney disease patients can suffer from intradialytic(meaning something that happens during dialysis) hypotension (IDH) that requires immediateintervention to prevent syncope and vital organs blood supply interruption. IDH is a frequent and seriouscomplication of chronic hemodialysis, linked to adverse long-term outcomes including increasedcardiovascular and all-cause mortality.The purpose of this research study is to use machine learning and ECGs obtained at hemodialysistreatment start to predict intradialytic hypotension during hemodialysis treatment and over the following30 days with the purpose of improving the prediction and management of intradialytic hypotension andmajor adverse cardiac events in end-stage kidney disease patients receiving maintenancehemodialysis.