A Single-Center Observational Study of the Feasibility and Acceptability of the Holistic Care Partner Program A Perinatal Nurse Navigation Program for Black Women
The purpose of this research study is to determine the feasibility and acceptability of the Holistic Care Partner Nurse Navigation Program for Black women, birthing people, and their partners or support persons.
A Single Center Observational Study of the Functional Synergistic Perilaryngeal Muscle Network (FSPMN) using synchronized multi-sensor surface electromyography to improve diagnosis and treatment of voice disorders
The purpose of this research study is to improve our understanding of voice disorders by creating a map of the muscles in the neck and see how they behave in people who have voice problems, as well as before and after standard of care treatment; during 10 vocal tasks; and before, during, and after a vocal street test.
A SINGLE-CENTER OBSERVATIONAL STUDY OF THE IMPACT OF TREMOR AFFECTING THE VOICE ON DEGLUTITION
Tremor affects ~1% of the global population or nearly 80 million people. In spite of this staggering figure, both nomenclature and treatment approaches are inconsistent. Many patients present with tremor affecting the voice, either in isolation or in combination with tremor of the limbs. Isolated vocal tremor was historically considered a clinical variant of essential tremor (ET). Recently updated classification criteria, however, exclude isolated voice tremor from ET classification. This controversy provides an ideal platform for meaningful patient-oriented research with the potential to substantively address issues related to communication-related disability.In the current study, we seek to understand differences in the clinical phenotypes between these two patient populations and the impact of voice tremor on structures of the upper aerodigestive tract and deglutition. In addition, foundational efficacy data regarding pharmacological therapy for patients with voice tremor will be collected.
A single-center observational study of the natural history and pathogenesis of hidradenitis suppurativa
A single-center observational study of the natural history and pathogenesis of hidradenitis suppurativa
A Single-Center Observational Study of the Pre-Operative and Post-Operative Corneal Endothelial Cell Density of Patients Undergoing Glaucoma Surgery
This study aims to investigate corneal endothelial cell migration and healing after glaucoma surgery using non-contact specular microscopy and tomography. Eighty patients undergoing glaucoma surgery will have corneal imaging taken pre-operatively, one month, three months, and six months post-operatively, and lastly at 1 year. Endothelial cell density and corneal thickness will be correlated and analyzed pre- and post-operatively. The focus of our study will be on tube-shunt surgery; other forms of glaucoma surgery such as MIGS may be included for comparison.
A Single Center Observational Study of Vascular Health and Hemodynamics in Heart Failure
Heart failure is associated with marked morbidity and mortality and yet role of vascular health in the pathogenesis of this disease remains poorly understood with limited therapeutic options. Examination of the vascular endothelium via brachial vein endovascular cell phenotyping in patients undergoing routine right heart catheterization offers a unique opportunity to examine the relationship between vascular endophenotypes and hemodynamics.
A single-center observational study of whole and regional brain volumes in patients with pediatric-onset demyelinating diseases
The purpose of this research study is to better understand how the brains of children and young adults with demyelinating diseases, such as multiple sclerosis (MS), change over time. The main goal is to track changes in the size and structure of the brain using brain scans called Magnetic Resonance Imaging(MRI) scans that are analyzed by a software called Icometrix that measures the size and structure of different regions in the brain (“volumetrics software”). By looking at these changes, the researchers want to see if they can find any links between brain changes and how the disease affects the subject’s abilities, thinking, and overall health over time. This study will also look for possible signs (called biomarkers) that could help doctors predict or understand these brain changes to help better manageand treat these diseases in children.
A Single-Center Observational Study to Develop EEG Biomarkers of Transition from Acute to Chronic Pain
We will enroll acute and chronic low back pain and control subjects. We will record high density EEG in these subjects, along with pain and mood questionnaires. Those with acute pain will be followed longitudinally with additional visits at 1, 3, and 6 months. We will use machine learning to develop and validate a biomarker for the transition from acute to chronic pain.
A Single-Center Phase 3 Study of RELAXaHEAD: A Behavioral Approach to Remote Migraine Management in Primary Care
Migraine is the second most disabling condition worldwide. We know that it can be hard for patients to access migraine care. Thus, we are conducting a study for patients of NYU Langone Health who have migraine. Specifically, NYU patients who have visited primary care, have a diagnosis of migraine, and are ages 16+ with 4+ headache days per month will be asked to take part in a smartphone-based migraine self- management program to determine if it will improve migraine-related disability, quality of life and headache days. In this study you will be asked to keep track of your headaches using a headache diary app called RELAXaHEAD. This app will allow you to keep track of your headache days, pain level, sleep, medications, cycle, and notes. Participation time for this intervention can be up to 15 minutes a day for 6 weeks. We will also continue to track use for up to 6 months to see if you think the management program is helpful beyond the initial 6 weeks.
A SINGLE CENTER PILOT STUDY ESTABLISHING TEST-RETEST RELIABILITY OF SWALLOWING PRESSURES COLLECTED WITH HIGH RESOLUTION PHARYNGEAL MANOMETRY (HRPM)
Difficulty swallowing (known as dysphagia) can have devastating consequences for health and quality of life. The current gold-standard assessment tool, videofluoroscopy (VF), allows real time visualization of swallowing via a video x-ray. Unfortunately, VF exposes the patient to radiation and therefore is limited in its use. A relatively new technique for quantifying swallowing physiology is called High Resolution Pharyngeal Manometry (HRPM) - it registers the pressures generated by the swallowing muscles on a catheter passed through the nose to the esophagus. Our team (speech pathology, otolaryngology, gastroenterology) recently acquired an HRPM system and is eager to employ it in our research grants with a focus on aging, disease progression, and treatment for swallowing disorders. However, at this time, very little is known about the test-retest reliability of this tool which leaves us unable to conduct realistic power calculations in these proposals. Therefore, we will plan to collect VF/HRPM test-retest data in 20 older adults two weeks apart.