The Effect of Bone-void filler on Anterior Knee Pain Following ACL Reconstruction with Bone-Patellar Tendon Bone Autograft
The purpose of this study is to evaluate the effect of and compare bone-void filler material on outcomes following anterior cruciate ligament (ACL) reconstruction with bone-patella-tendon-bone (BPTB) autograft. During ACL reconstruction surgery with BPTB, surgeons remove a portion of the patella (knee cap) and may fill in the missing bone using a bone-void filler. There are different kinds of bone-void fillers that are used by surgeons. However, while each material has its own benefits and risks, there is no goldstandard or preferred material among surgeons. This study will compare bone obtained from the BPTB graft harvest, and bone graft plus calcium phosphate cement, and bone graft plus demineralized bone matrix (DBM) to see if there is a difference in knee pain as well as knee function and subject quality of life after surgery.
The use of cannabidiol (CBD) in pain reduction for knee osteoarthritis. A Double-Blind Randomized Control Study
The purpose of this study is to see if cannabidiol (CBD) orally dissolving tablets (ODTs) can lessen pain needed in people with knee osteoarthritis. CBD comes from the cannabis plant and is non-psychoactive (i.e. does not produce a ‘high’ or altered mental state) as compared to tetrahydrocannabinol (THC), another compound found in cannabis. Researchers are studying different forms of CBD for potential use in treating pain, inflammation, and illnesses. One form of CBD is Food and Drug Administration (FDA) approved for treating severe types of epilepsy that affect children. In this study, the CBD ODT is considered an investigational drug because it is not Food and Drug Administration (FDA) approved for osteoarthritis.