Prospective Database of Clinical Outcomes Following Cryotherapy for ablation of clinically localized prostate cancer
Primary Objective: To record the treatment results and impact on clinical parameters following of Cryotherapy for ablation of clinically localized prostate cancer. Primary outcome variables of interest include PSA-progression free survival, histologic evaluation of treatment efficacy and imaging surveillance of treatment effects.Secondary Objectives: To determine the long-term urinary and sexual side effects following Cryo prostate ablation treatment.Background and RationaleMany reports of clinical outcomes following treatment of localized prostate cancer suffer from lack of prospective long-term data using objective and validated outcome instruments. The purpose of this database is to prospectively collect data to assessing oncologic outcomes and urinary/sexual function after Cryoablation of prostate cancer with the intent to guide further research and improve patient care. Only patients of Herbert Lepor, M.D. and James Wysock, M.D. will be entered into this database.
Prospective Multi-Center Pediatric Spine Patient Registry
The goal of this project is to create a registry of children and adults (with disease progression from childhood) with spine and chest wall disorders.
Prospective Multicenter Single-Arm Investigational Device Exemption (IDE) Study of the Shockwave Intravascular Lithotripsy (IVL) System with the Shockwave Javelin Coronary IVL Catheter (FORWARD CAD IDE Study)
The purpose of this research study is to assess the safety and effectiveness of a new, investigational catheter for use with the Shockwave Intravascular Lithotripsy (IVL) System prior to stenting.
Prospective NIPT Sample Collection Protocol
This study is being done to develop and validate an investigational noninvasive prenatal test to determine chromosomal anomalies. Pregnant women >10 weeks gestation with positive NIPT results will enroll and provide a blood sample and de-identified health information during a single visit. The samples will be sent to Bio-Rad for development and validation of the investigational assay. Leftover de-identified samples and data are stored for optional future research if subjects provide informed consent. The results of the assay will not be used to guide care and will not be shared with subjects. Bio-Rad will share the de-identified data with the PI for the intent of publication.
Prospective observational registry for cystinuria patients on Thiola EC therapy
In this phase 4 study we will observe the tolerance and effect of Thiola EC in patients with cystinuria. The drug will be administered three times a day to people who are currently taking tiopronin, or for new patients who require tiopronin, as determined by their treating physician, in order to address continued cystine stone formation.
Prospective Pilot Study on Geniculate Artery Embolization for Treatment of Persistent Knee Pain Post Total Knee Arthroplasty
TKA is an effective intervention for the treatment of chronic knee pain and disability in patients with knee OA. However, approximately 10% to 34% of patients experience persistent chronic pain after TKA. Persistent postsurgical pain is defined as persistent pain of at least three to six months duration that develops or increases in intensity after surgery and affects health-related quality of life. After TKA, patients with persistent pain may be disappointed with the outcome as pain severity plateaus. While the etiology of persistent pain following TKA is multifactorial, there is growing evidence that synovitis and patient-specific inflammatory response to surgery may influence the long-term clinical outcome following TKA. Over the past decade, embolization of the genicular arteries has been evaluated for the treatment of knee OA, showing significant improvement in knee pain, function, and quality of life. The goal of this proposed prospective, single-center, single-arm trial is to evaluate the safety and efficacy of GAE for treatment of persistent postsurgical knee pain following TKA.
Prospective Randomized Three Arm Study of lumbar Spinal Fusion Graft Efficacy: Bone marrow aspirate concentrate & Allograft versus Recombinant Bone Morphogenetic Protein-2 (BMP) versus Control Group
This study will be a prospective, randomized clinical study at a single-center, NYU Langone Medical Center. It is intended to compare and evaluate the efficacy of subjects who are either treated with (1) bone marrow aspirate concentrate (BMAC) and allograft or (2) recombinant human bone morphogenetic protein-2 (BMP) or (3) autograft (control) during lumbar spinal fusion with interbody support. The clinical, radiographic, and Health Related Quality of Life (HRQOL) outcomes will be assessed in operatively treated adult spinal degenerative disease patients undergoing lumbar spinal fusion.
Prospective Registry-Based Study Evaluating the Effectiveness and Safety of Odevixibat in Participants with Alagille Syndrome (ALGS)
The purpose of this research study is to gather information on how well Bylvay (Odevixibat) works for treating Alagille syndrome using real-life data collected over time.
Prostate Artery Embolization for Male Urinary Dysfunction | NYU Langone Health
NYU Langone doctors treat some types of urinary problems with nonsurgical embolization to improve bladder function.
Prostate Cancer | NYU Langone Health
Doctors at NYU Langone’s Perlmutter Cancer Center are experts in the most advanced techniques for prostate cancer diagnosis.