Phase III Trial of Single Fraction Stereotactic Radiosurgery (SRS) Versus Fractionated SRS (FSRS) For Intact Brain Metastases
This phase III trial compares the effectiveness of fractionated stereotactic radiosurgery (FSRS) to usual care stereotactic radiosurgery (SRS) in treating patients with cancer that has spread from where it first started to the brain. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. FSRS delivers a high dose of radiation to the tumor over 3 treatments. SRS is a type of external radiation therapy that uses special equipment to position the patient and precisely give a single large dose of radiation to a tumor. FSRS may be more effective compared to SRS in treating patients with cancer that has spread to the brain.
Phenotypic and genotypic study of Keratoconus
Keratoconus is a disease in which the cornea is abnormally steep and thin. It affects approximately 1 in 2000 individuals and usually begins in the second decade of life. Keratoconus is a progressive disorder which results in loss of vision that cannot be alleviated by contact lenses or glasses alone, and is a leading indication for corneal transplantation in developed countries (Udar et al., IOVS 47: 3445-3351, 2006). Keratoconus has a strong genetic component, and while several genes are suspected clear causative genes and underlying pathogenic processes have not been identified yet. We will enroll isolated keratoconus and familial cases and unaffected members of the families when available. The goal of our research is to identify genes that harbor mutations that contribute to keratoconus and underlying biochemical processes that are altered as a result and contribute to keratoconus pathogenesis. The subject population consists of individuals diagnosed with keratoconus and unaffected relatives in families. Individuals/families are ascertained through support groups, web-based listings of research studies and genetic testing services, and a keratoconus research website that Dr. Chakravarti and other team members maintain. The identities of the study participants will be known only to Dr. Chakravarti, the study coordinator, physicians in the team and the post-doctoral fellow(s) working directly on the project.DNA, lymphocytes, and lymphoblastoid cell lines may be prepared from the blood samples for future use. Molecular analysis using markers and sequencing, and statistical analysis of these data, will be used to identify regions of human chromosomes where putative keratoconus disease genes reside. Analyses of DNA sequences of all coding region of genes from keratoconus subjects compared to published control subjects DNA will be performed to identify disease specific variants. Additionally to understand disease pathogenesis, subsets of patients may be asked to provide tear samples or impression cytology of their conjunctiva (a thin tissue paper is placed under the eyelid area and lifted off which brings small number of patient cells that can be visualized by histology). Study subjects will not directly benefit from participation; the purpose of the study is to better understand the etiology of keratoconus, leading to improved detection, treatment, and management. Results will not be disclosed to participants nor their health care providers, unless medically relevant.
PHINDER: Pulmonary Hypertension Screening in Patients with Interstitial Lung Disease for Earlier Detection
The PHINDER study is a research study that will collect data to better understand screening for pulmonary hypertension (PH). The goal is to use the data collected to potentially improve PH screening in people who have interstitial lung disease (ILD). Participation in the PHINDER study will help researchers learn more about early detection of PH. The PHINDER study includes procedures that your doctor routinely performs in the care of ILD patients. There is no experimental treatment included in this study and all study-related procedures will be provided at no cost.
Photodynamic Therapy for Macular Degeneration | NYU Langone Health
NYU Langone doctors can perform photodynamic therapy in conjunction with injections to manage wet macular degeneration.
Photopheresis for Cutaneous T-Cell Lymphoma | NYU Langone Health
NYU Langone doctors may use photopheresis to treat cutaneous T-cell lymphoma found in the blood.
Phototherapy & Laser Treatment for Vitiligo | NYU Langone Health
NYU Langone dermatologists use phototherapy and laser treatments to minimize the appearance of white patches caused by vitiligo.
Phototherapy for Eczema & Dermatitis | NYU Langone Health
NYU Langone doctors offer phototherapy to relieve symptoms of eczema and dermatitis.
Physiatry for Children | NYU Langone Health
Pediatric physiatrists at Hassenfeld Children’s Hospital at NYU Langone provide medical and rehabilitation care.
Physical & Integrative Therapies for Frozen Shoulder | NYU Langone Health
NYU Langone doctors may recommend physical therapy or integrative therapies to relieve the symptoms of frozen shoulder.
Physical & Mental Rest for Concussion | NYU Langone Health
NYU Langone doctors advise physical and mental rest for concussion.