Young Onset Parkinson s disease Subtypes and Pathogenic Mechanisms
Young Onset Parkinson’s disease refers to a -group of patients in which the disease starts earlier in life (before the age of 50 years) and has a profound impact on most of patient’s life and on important productive years. Our current knowledge regarding the pathogenic mechanisms of YOPD is lacking, and understanding these are crucial for the successful design of therapeutic strategies and stratifying patients for clinical trials. The proposed research is relevant to public health because it aims to clarify the contribution of recognized important pathogenic mechanisms of Parkinson’s disease (genetics, inflammation, and alpha-synuclein accumulation) in patient with Young onset Parkinson’s disease to help patient stratification for clinical counseling and clinical trials.With the present project we propose to study a cohort of subjects with YOPD (n = 150) compared to n=50 LOPD and n=50 CTRLs. For each enrolled subject we will collect clinical data and biospecimens including blood specimen, skin punch biopsy. CSF will be collected from a sub-cohort of subjects (n = 20 YOPD, n = 20 LOPD, n = 20 CTRLs).
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