Support for Cerebral Palsy in Children | NYU Langone Health
Doctors at Hassenfeld Children’s Hospital at NYU Langone offer ongoing support for children and teens who have cerebral palsy.
World Trade Center Particulate Matter Induced Cardiorespiratory and Vascular Dysfunction: a MultiOmic Approach
Particulate matter (PM) associated cardiorespiratory and vascular dysfunction (CaRVD) poses a significant global health burden. The World Trade Center (WTC) destruction on September 11, 2001 led to an intense deposition of particulate matter (WTC-PM) into aerodigestive system. WTC associated morbidities include respiratory, gastrointestinal, chronic rhinosinusitis, cancer, mental health concerns and more recently a focus has been on cardiovascular disease. Our proposal will investigate the development of WTC-cardiorespiratory and vascular dysfunction (WTC-CaRVD) which is firmly within the purview of the James Zadroga 9/11 Health and Compensation Act. WTC-PM exposure causes heterogeneous obstructive airways disease (OAD) patterns, which include airway hyperreactivity (AHR) and loss of FEV1. Early diagnosis and therapeutic options are few, in part due to our limited understanding of their pathogenesis. While pulmonary vascular changes are classically thought to occur due to the hypoxemia of late OAD, recent investigations show that vascular dysfunction occurs early in OAD. This vascular hypothesis of OAD postulates that pulmonary vasculature remodeling leads to loss of lung function. Early evidence of WTC-CaRVD includes increased prevalence of cardiovascular disease risk factors such as metabolic syndrome, elevated pulmonary artery/aorta ratio, and cardiovascular biomarkers (such as CRP). Murine models of WTC-PM exposure show inflammation, AHR both acutely and persistently and reflect what is seen in FDNY 1st responders. Airway and cardiac remodeling were also persistent features of WTC-PM exposure in our murine models. Therefore, we will focus on Heme Oxygenase-1 (HO-1), a mediator of oxidative stress, known to stimulate collagen formation and is also induced after WTC-PM exposure. Furthermore, pathways and mechanisms of WTC-CaRVD warrant further study and are the focus of our 5-year proposal. Our HYPOTHESIS is that WTC-PM exposure causes WTC-CaRVD mediated by HO-1. First responders with AHR will have features of WTC-CaRVD, and will demonstrate a unique biomarker profile compared to controls. Innovative aspects of this application include novel imaging modalities and multiOmic (radiome/metabolome/methylome) assessments. These hypotheses will be explored in three AIMs. AIM 1, we will explore the translatability of our findings in the FDNY WTC cohort. AIM 2 will phenotype serum biomarkers/metabolites, epigenetics, histology and in vivo imaging (echocardiography, MRI, and µPET/µCT) of WTC-CaRVD. Furthermore, we will utilize mice genetically deficient in HO-1 and exogenously attenuate HO-1 in our murine WTC-PM model, AIM 2 and 3. AIM 3 will quantify end organ involvement and loss/gain of function of HO-1 by myography and immunohistologic expression of vascular markers. Confirmation of the relevance of the vascular and airway remodeling of WTC-PM associated AHR would allow us to then focus on early detection and tailor our therapeutics in the WTC-PM exposed cohorts on mediators of oxidative stress.
Abdominal Core Health & Hernia Program | NYU Langone Health
NYU Langone’s Abdominal Core Health and Hernia Program provides simple and complex hernia repair and abdominal wall reconstruction.
Adolescent Medicine Program | NYU Langone Health
Doctors at the Adolescent Medicine Program, part of Hassenfeld Children’s Hospital at NYU Langone, care for patients ages 11 to 24.
Chemotherapy for Hodgkin Lymphoma in Children | NYU Langone Health
Doctors at Hassenfeld Children’s Hospital at NYU Langone prescribe chemotherapy drugs for Hodgkin lymphoma.
Cystic Fibrosis in Children | NYU Langone Health
Doctors at Hassenfeld Children’s Hospital at NYU Langone offer expert diagnosis, treatment, and support for children with cystic fibrosis.
Flatbush Family Health Center at NYU Langone | NYU Langone Health
Flatbush Family Health Center at NYU Langone provides primary and specialized care.
Heart Healthy Nutrition Program | NYU Langone Health
At NYU Langone’s Center for the Prevention of Cardiovascular Disease, we help people make dietary changes to reduce their heart disease risk.
Lung Cancer Center Leadership | NYU Langone Health
NYU Langone’s Lung Cancer Center is led by a team of experts in lung cancer treatment and research.
Minimally Invasive Procedures for Dry Eye Disease | NYU Langone Health
NYU Langone doctors may recommend minimally invasive procedures, including punctal plugs and cauterization, to treat dry eye disease.