Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3) Protocol: ATRI-001
Discover, optimize, standardize, and validate clinical trial measures and biomarkers used in ongoing AD research.Aim 1. Longitudinal changes in cognition and associated biomarkersDetermine and define those measures of cognition and function, including composite measures, and those biomarker measures, which capture longitudinal change with the highest statistical power to detect treatment effects in clinical trials.Longitudinal change of cerebral tau measured with 18F-AV-1451 PET (AV-1451) will be correlated/compared with other measures.Aim 2. Prediction of cognitive declineDetermine which clinical, cognitive, and biomarker measures that best predict decline of cognition in CN, MCI, and AD participants. In addition, determine which biomarker changes correlate with cognitive decline, with focus on AV-1451 PET.Aim 3. ValidationValidate biomarker measures obtained at Baseline and longitudinally by correlating results with “gold standard” clinical measurements and pathology.Aim 4. Clinical trial designDetermine the optimum outcome measures with attention to cognitive decline and AV-1451 PET, predictors of cognitive decline, and inclusion/exclusion criteria for clinical trials of cognitively normal participants (for secondary preclinical AD trials), MCI patients (for prodromal AD trials) and participants with early dementia due to AD.Aim 5. DiscoveryTo determine the effects of other known disease proteins found in AD brains and genes, as well as newly discovered genes, proteins, and analytes that provide useful information concerning the pathogenesis/diagnosis of AD.Protocol Clarifications:only those with the capacity to consent will be considered for retention in the ADNI study.
Nursing at NYU Langone | NYU Langone Health
NYU Langone’s nationally recognized nurses are committed to providing world-class care and improving patient outcomes.
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NYU Langone's Sports Performance Center offers sports performance testing and programs that can help maximize your athletic ability.
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Orthopedic surgeons and sports medicine doctors at NYU Langone’s Sports Medicine Center treat athletic, overuse, and everyday injuries.
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... Centers at NYU Langone at: kathleen.hopkins@nyulangone.org. ii Table of Contents Section Pages MISSION 1 ... and Plans: Preventing Chronic Diseases 24-49 iii Section Pages A. Tobacco Free Community 24-31 B. Health ...
acp-conversation-guide-english-fillable-2025.pdf
... goals from prolonging my life to a focus on my comfort? You should also consider talking to your ... Reflecting on your values and beliefs: When your health care agent (refer to page 3 for definition) and loved ...
acp-conversation-guide-english-printable-2025.pdf
... goals from prolonging my life to a focus on my comfort? You should also consider talking to your ... Reflecting on your values and beliefs: When your health care agent (refer to page 3 for definition) and loved ...
Child Study Center | NYU Langone Health
The Child Study Center, part of Hassenfeld Children’s Hospital at NYU Langone, treats children with mental health and developmental conditions.
Center for Blood Cancers | NYU Langone Health
Experts at the Center for Blood Cancers, part of Perlmutter Cancer Center, treat blood cancers such as leukemia, lymphoma, and multiple myeloma.