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EVEREST-2: A Seamless Phase 1/2 Study to Evaluate the Safety and Efficacy of A2B694 an Autologous Logic-gated Tmod CAR T in Heterozygous HLA-A*02 Adults with Recurrent Unresectable Locally Advanced or Metastatic Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression
econditioning lymphodepletion) for different cancers that express mesothelin (MSLN). First, the study team will test it on a small number of patients to see if it has few side effects and if it is effective in treating the cancers. Then, they'll include more patients to check there are few side effects again and see how well it works. If it seems effective with few side effects, they study team will continue testing it on more patients with different types of cancer. The study team will closely watch how the treatment works for each type of cancer. If it doesn't seem to be helping enough for a specific type of cancer, they might not include more patients with that cancer type. All the patients in the second part of the study will get the best dosage found from the first part of the study.
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