Alzheimer’s Disease Research Center Cores | NYU Langone Health
NYU Langone’s Alzheimer’s Disease Research Center comprises nine research groups, or cores, working to achieve the center’s shared goals.
mind-matters-sf2021.pdf
... September 2021! Past Events: In February 2021, Dr. Ricardo Osorio presented on a topic that seems ... or microbleeds—challenging complications that often limit immunotherapy studies. continued on next page ...
mind-matters-black-history-month-2025.pdf
... Grossman School of Medicine, working with Dr. Ricardo Osorio, he honed his expertise in the intersection ... ’s Research Pioneer By: Abena Dinizulu, BS continued on next page Solomon Carter Fuller was born on August 11 ...
Transcranial Photobiomodulation as a Potential Modulator for Sleepiness
The purpose of this research study is to investigate a potential treatment for residual sleepiness in those who are treating their sleep apnea. Specifically, this clinical trial aims to treat residual sleepiness in those with sleep apnea who have already been treated with CPAP and are stillexperiencing tiredness. The study will use a non-invasive treatment called transcranial photobiomodulation which is intended to help people feel more awake.
Treatment Of OSA On Sleep-Dependent Memory And Blood Biomarkers In Black Study Participants
The purpose of this research study is assess whether treating sleep apnea affects memory and other brain-related health factors related to Alzheimer’s disease and related dementias (AD). This study is evaluating a new way of starting therapy for obstructive sleep apnea (OSA).
Monitoring outcomes of new disease modifying interventions and optimization of risk assessment in Alzheimer's disease
The purpose of this study is to develop an easier way to predict brain changes that might occur from Alzheimer's treatments, especially those using antibody therapies like Leqembi (Lecanemab). These therapies can occasionally cause brain changes, like swelling or small internal bleeding, which are usually harmless but sometimes can cause symptoms like headaches or confusion. Normally, these changes are monitored with MRI scans. However, we want to see if a simple blood test could serve as a more convenient alternative to MRIs.
Racial diffErences in the aSsociation Of sLow waVe slEep aNd Tau (RESOLVENT II)
This pilot proposal will examine whether racial differences exist in the association between SWS/SWA and in-vivo regional tau-PET signal for a given level of global Aß burden. To generate preliminary data for a larger R01 application, we will leverage data and resources from NYU Alzheimer’s Disease Research Center (ADRC NYULH STUDY ID#: s20-00427) and two affiliated ongoing NIH supported R01 studies (2R01AG056031 NYULH STUDY ID#: s17-01005 and 1R01AG056531 NYULH STUDY ID#: s18-01302). Altogether, subjects will include 100 cognitively normal (50 blacks from NYULH STUDY ID#: s18-01302 & 50 whites {35 from NYULH STUDY ID#: s17-01005 & 15 from NYULH STUDY ID#: s20-00427 ) without OSA (thereby eliminating a possible confounder of reduced SWS), ages 60-75, matched on age, sex, BMI, education and income.
SLEEP AGING AND RISK FOR ALZHEIMER S (RESUBMISSION-1)
Age-related sleep changes and common sleep disorders like obstructive sleep apnea (OSA) may increase amyloid burden and represent risk factors for cognitive decline. In this study, we will extend our prior work using home-sleep monitoring and cerebrospinal fluid collection in normal older adults by directly interrogating the brain using 2-night nocturnal polysomnography (NPSG) and amyloid deposition using C-PiB PET/MR both at baseline and at 24 month follow-up. This study has the potential to identify the mechanisms by which age-related sleep changes contribute to AD neurodegeneration in cognitively normal elderly, of whom can profit the most from sleep preventive strategies.
Cellular Viscosity as a Marker for Alzheimer s Disease Pathology: A Combined Multiparametric MR Spectroscopy and PET Study
This project proposes the use of Magnetic Resonance Spectroscopic Fingerprinting (MRSF) to quantify changes in intracellular viscosity separately within neurons and astrocytes and assess AD pathophysiology. We will work with the NYU AD Research Center to include our MRSF sequence within their routine tau-PET/MRI protocol, allowing for serial follow-up of a cohort of 100 cognitively normal individuals and patients with mild cognitive impairment. Both sets of subjects will undergo yearly neurocognitive assessments, plasma Aß and plasma tau evaluations; and biennial Aß-PET, tau-PET, and MRI+MRSF scans. The expected outcome of this work is a set of novel markers for neuronal and astrocytic intracellular viscosity which will potentially become biomarkers for early prediction of neurodegeneration and cognitive decline in AD, addressing gaps in the current imaging armamentarium of the AT(N) network.
Chronic Pain and Postoperative Cognitive Function in the Elderly: a Prospective Observational Study
To assess the possible interrelation between pre-operative chronic pain and postoperative cognitive dysfunction (POCD) in the elderly, we plan to enroll patients undergoing planned surgery. To evaluate the initial pain states, pain and mood questionnaires will be used prior to surgery. To explore the potential interrelation between chronic pain and POCD, pre-, and postoperative cognitive dysfunction will be assessed using common cognitive tests. Moreover, neurocognitive biomarkers will be assessed with blood samples drawn peri- and postoperatively with optional EEG-recordings prior to and after surgery. An optional MRI will be performed in randomly assigned subjects prior to surgery.