mind-matters-ss2020.pdf
... ADRC and Barlow Clinic registered! • Dr. Ricardo Osorio presented our very first Learn at Home series ... ://time.com/5809322/social-dis- tancing-book-clubs/ • Tolstoy Together: read War and Peace only a few pages a day ...
Microsoft Word - NYU Langone COVID-19 Research Studies_10.29.20_nb.docx
... ’s disease Risk (Monitor Neuro-covid19) Primary Investigator: Ricardo M. Osorio Suarez, MD Department ... Investigator: Ricardo.M..Osorio.Suarez,.MDDepartment of PsychiatrySponsor:. National. Institute.on. Aging Neuro ...
Psychiatry Publications | NYU Langone Health
Physician–scientists in NYU Langone’s Department of Psychiatry publish their research in prestigious journals.
The MAINSTAY study: Mechanisms of rAcial dIfferences in the relatioNship between Obstructive Sleep Apnea and in vivo Tau deposition in the context of AmYloid burden
This research study is being done to collect information about obstructive sleep apnea (OSA) as a potential risk factor that may increase Alzheimer’s disease (AD) burden, particularly in African-Americans, and understand racial differences in markers of AD.
Depression treatment and A dynamics: A study of Alzheimer s disease risk
The purpose of this research study is to test if a reduction in depressive symptoms in response to treatment with an antidepressant improves levels of certain proteins which have been associated with increased risk for the development of Alzheimer's disease (AD).
Mechanisms of sleep deficiency and effects on brain injury and neurocognitive functions among older blacks
The purpose of this study is to assess the determinants of Sleep Deficiency and delineate their potential role in explaining observed disparities in the brain health of older blacks, indexed by novel AD brain biomarkers and examinations of cognitive impairment in a multicultural community sample. Eligible participants include community-dwelling older adults aged 55-75 years older with and without memory complaints. Study participants will receive a comprehensive health screening with ambulatory recording devices, including, state-of-the-science geospatial analytics, and testing of cognition.
Cellular Viscosity as a Marker for Alzheimer s Disease Pathology: A Combined Multiparametric MR Spectroscopy and PET Study
There is a need for imaging markers to help prognosticate progression to Alzheimer’s Disease (AD). We use a novel method, named Magnetic Resonance Spectroscopic Fingerprinting (MRSF), to assess changes in the cellular microenvironment which may contribute to AD. In combination with positron emission tomography and blood plasma measurements, we hypothesize that MRSF will provide new markers forpredicting neurodegeneration and cognitive decline. This study will last about 5 years. Your participation will involve two visits over two years. During each visit, you will be asked to undergo an MRI scan of your brain. You will not have to take any medications or have any injections as part of this study.
Locus-coeruleus function in normal elderly and AD risk (LEAD)
(S,S)-[11C]Methylreboxetine ((S,S)-[11C]MRB) is a radioligand developed for positron emission tomography (PET) imaging of the brain adrenergic receptors. In ongoing clinical studies, 11C-MRB PET is currently being examined to determine whether the tracer has utility in the differential diagnosis and follow-up of Alzheimer’s disease risk and in evaluating the efficacy of preventive therapies. To enable the continued use of 11C-MRB and to confirm safety, it is important to determine the radiation exposure caused by such studies. The use of this tracer has been approved by the FDA since 2005. This tracer has been used for PET imaging of over 500 human studies with no major side effects. Before this tracer can be used in our main study, the dosimetry results need to be analyzed and reported locally prior to the start of the study.
Racial diffErences in the aSsociation Of sLow waVe slEep aNd Tau (RESOLVENT II)
The purpose of this research study is to is to test whether poor slow wave sleep (SWS), the most restful sleep stage, is one of the physiological factors that increase the risk for Alzheimer’s disease among African-Americans when compared to Caucasians (hereafter referred to as ‘whites’). African-Americans (AAs) have a higher risk of both Alzheimer’s disease (AD) and vascular risk factors for Alzheimer’s disease, such as diabetes and high blood pressure, when compared to whites. Sleep characteristics vary between AAs and whites. AAs take longer to fall asleep, have shorter sleep duration, lower sleep quality and less slow wave sleep (SWS) duration than whites. This research study is being done to collect information about sleep as a potential risk factor that may increase Alzheimer’s disease burden particularly in African-Americans.
Sleep Aging and Risk for Alzheimer's
Age-related sleep changes and common sleep disorders like obstructive sleep apnea (OSA) may increase amyloid burden and represent risk factors for cognitive decline. In this study, we will extend our prior work using home-sleep monitoring and cerebrospinal fluid collection in normal older adults by directly interrogating the brain using 2-night nocturnal polysomnography (NPSG) and amyloid deposition using C-PiB PET/MR both at baseline and at 24 month follow-up. This study has the potential to identify the mechanisms by which age-related sleep changes contribute to AD neurodegeneration in cognitively normal elderly, of whom can profit the most from sleep preventive strategies.