Gut Microbiome in Food Protein-Induced Enterocolitis Syndrome: An Observational Study
Food protein-induced enterocolitis syndrome (FPIES) is a non IgE-mediated food allergy that manifests with predominantly gastrointestinal symptoms and usually starts in the first year of life. There is no diagnostic biomarker and no treatment for FPIES beyond food avoidance, reflecting poorly understood pathophysiology. This is a prospective observational study, which will compare fecal microbiota, fecal short chain fatty acids and metabolomics between infants with FPIES and control infants and infants without food allergy, 0-12 months old. It will also compare mucosal immunity via epigenetic markers in blood in infants with FPIES, and infants with IgE-mediated food allergy. Stool samples will be collected from 50 infants with FPIES and 50 sex and age matched control infants birth through 12 months. Optional blood samples will be collected only from infants with FPIES and infants with IgE-mediated food allergies (0-12 months old). A questionnaire will be used to obtain information detailing the infant’s feeding, medical, birth, and family history.
Integrated multi-omics approaches to precision medicine in kidney disease (iMAP-Kidney)
The primary objective of the study is to establish a biorepository (tissue bank) for the storage of plasma, serum, DNA, RNA, urine, and fresh tissue from kidney and kidney allograft biopsies, from patients undergoing kidney biopsy. This objective will be accomplished through the following: 1) establishing a clinical registry containing information linked from the patient’s medical record; 2) digitizing kidney histology slides from kidney tissue biopsies; 3) obtaining leftover archival tissue if extra fresh tissue collection is deemed unsafe by the physician, if the patient is pregnant, or if the patient refuses extra tissue collection and 4) allowing for accessibility to newly obtained samples for related studies.
Psoriatic Response and Onset: Genes Radiology Environment Skin and Synovium)
This is a longitudinal, observational cohort study to aimed to understand the clinical and biologic underpinnings of psoriasis and psoriatic arthritis development and severity. To this aim, we will collectThis will contain information related to each participant’s age, gender, race, past and present medical history, family history and social history, medications, and patient reported outcomes, and disease state. Additionally, biosamples such as blood, stool, skin biopsies, skin swabs, synovial fluid, synovial biopsies, saliva/buccal swabs, and hair follicle samples will be obtained as appropriate for each patient. Ultrasounds and brain MRIs will also be offered to a subset of patients. While a core set of samples and questions will be required, additional samples and procedures will be optional. Patients will be followed up to 4 times per year.
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Emergency Department at NYU Langone Hospital—Suffolk | NYU Langone Health
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