ACNS2021: A Phase 2 Trial of Chemotherapy followed by Response-Based Whole Ventricular & Spinal Canal Irradiation (WVSCI) for Patients with Localized Non-Germinomatous Central Nervous System Germ Cell Tumor
Site for This phase II trial studies the best approach to combine chemotherapy and radiation therapy (RT) based on the patient's response to induction chemotherapy in patients with non-germinomatous germ cell tumors (NGGCT) that have not spread to other parts of the brain or body (localized). This study has 2 goals: 1) optimizing radiation for patients who respond well to induction chemotherapy to diminish spinal cord relapses, 2) utilizing higher dose chemotherapy followed by conventional RT in patients who did not respond to induction chemotherapy. Chemotherapy drugs, such as carboplatin, etoposide, ifosfamide, and thiotepa, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy x-rays or high-energy protons to kill tumor cells and shrink tumors. Studies have shown that patients with newly-diagnosed localized NGGCT, whose disease responds well to chemotherapy before receiving radiation therapy, are more likely to be free of the disease for a longer time than are patients for whom the chemotherapy does not efficiently eliminate or reduce the size of the tumor. The purpose of this study is to see how well the tumors respond to induction chemotherapy to decide what treatment to give next. Some patients will be given RT to the spine and a portion of the brain. Others will be given high dose chemotherapy and a stem cell transplant before RT to the whole brain and spine. Giving treatment based on the response to induction chemotherapy may lower the side effects of radiation in some patients and adjust the therapy to a more efficient one for other patients with localized NGGCT.
Acoustic Neuroma | NYU Langone Health
NYU Langone doctors offer surgical and nonsurgical treatments for people who have acoustic neuroma, a type of benign brain tumor.
Active Surveillance of Prostate Cancer | NYU Langone Health
Doctors at NYU Langone’s Perlmutter Cancer Center may recommend active surveillance for some men with slow-growing forms of prostate cancer.
Acute Lymphoblastic Leukemia | NYU Langone Health
NYU Langone specialists work together to diagnose acute lymphoblastic leukemia and develop a customized treatment plan.
Acute Myeloid Leukemia | NYU Langone Health
Perlmutter Cancer Center doctors diagnose and manage acute myeloid leukemia and provide support throughout recovery.
ADAPTATION TO FREQUENCY-PLACE FUNCTIONS IN COCHLEAR IMPLANT USERS
It is a basic study that will examine adaptation to frequency-place maps in cochlear implant users. The main outcome measures will be measures of speech and music perception, sound quality, and sensory acuity.
Addiction | NYU Langone Health
NYU Langone psychiatrists provide counseling to people who have drug or alcohol addictions.
Adolescent Dialectical Behavior Therapy Program | NYU Langone Health
NYU Langone’s Child Study Center offers adolescent dialectical behavior therapy.
Adolescent Healthy Weight Program | NYU Langone Health
At the Adolescent Healthy Weight Program, part of Hassenfeld Children’s Hospital at NYU Langone, we offer medical and surgical weight loss.
Adolescent Medicine Program | NYU Langone Health
Doctors at the Adolescent Medicine Program, part of Hassenfeld Children’s Hospital at NYU Langone, care for patients ages 11 to 24.