A SINGLE-CENTER OBSERVATIONAL STUDY OF PAIN PHENOTYPES IN PSORIATIC ARTHRITIS
This study is an observational study of individuals with psoriatic arthritis (PsA) to define types of pain. We aim to better understand the prevalence of persistent joint pain in PsA, better phenotype pain in PsA, and understand what psychosocial factors may contribute to the development of persistent pain. This study will help promote awareness of the impact of psychosocial factors in PsA and help provide preliminary data to designed adjuvant treatments for those with PsA and persistent pain.
A Single-Center Observational Study of Targeted Muscle Reinnervation in Amputees
This is a prospective, observational, longitudinal study that will follow the course of recovery for amputees who undergo targeted muscle reinnervation for treatment of limb pain.
A Single-Center Observational Study of the Feasibility and Acceptability of the Holistic Care Partner Program A Perinatal Nurse Navigation Program for Black Women
The purpose of this research study is to determine the feasibility and acceptability of the Holistic Care Partner Nurse Navigation Program for Black women, birthing people, and their partners or support persons.
A Single Center Observational Study of the Functional Synergistic Perilaryngeal Muscle Network (FSPMN) using synchronized multi-sensor surface electromyography to improve diagnosis and treatment of voice disorders
The purpose of this research study is to improve our understanding of voice disorders by creating a map of the muscles in the neck and see how they behave in people who have voice problems, as well as before and after standard of care treatment; during 10 vocal tasks; and before, during, and after a vocal street test.
A SINGLE-CENTER OBSERVATIONAL STUDY OF THE IMPACT OF TREMOR AFFECTING THE VOICE ON DEGLUTITION
Tremor affects ~1% of the global population or nearly 80 million people. In spite of this staggering figure, both nomenclature and treatment approaches are inconsistent. Many patients present with tremor affecting the voice, either in isolation or in combination with tremor of the limbs. Isolated vocal tremor was historically considered a clinical variant of essential tremor (ET). Recently updated classification criteria, however, exclude isolated voice tremor from ET classification. This controversy provides an ideal platform for meaningful patient-oriented research with the potential to substantively address issues related to communication-related disability.In the current study, we seek to understand differences in the clinical phenotypes between these two patient populations and the impact of voice tremor on structures of the upper aerodigestive tract and deglutition. In addition, foundational efficacy data regarding pharmacological therapy for patients with voice tremor will be collected.
A single-center observational study of the natural history and pathogenesis of hidradenitis suppurativa
A single-center observational study of the natural history and pathogenesis of hidradenitis suppurativa
A Single-Center Observational Study of the Pre-Operative and Post-Operative Corneal Endothelial Cell Density of Patients Undergoing Glaucoma Surgery
This study aims to investigate corneal endothelial cell migration and healing after glaucoma surgery using non-contact specular microscopy and tomography. Eighty patients undergoing glaucoma surgery will have corneal imaging taken pre-operatively, one month, three months, and six months post-operatively, and lastly at 1 year. Endothelial cell density and corneal thickness will be correlated and analyzed pre- and post-operatively. The focus of our study will be on tube-shunt surgery; other forms of glaucoma surgery such as MIGS may be included for comparison.
A Single Center Observational Study of Vascular Health and Hemodynamics in Heart Failure
Heart failure is associated with marked morbidity and mortality and yet role of vascular health in the pathogenesis of this disease remains poorly understood with limited therapeutic options. Examination of the vascular endothelium via brachial vein endovascular cell phenotyping in patients undergoing routine right heart catheterization offers a unique opportunity to examine the relationship between vascular endophenotypes and hemodynamics.
A single-center observational study of whole and regional brain volumes in patients with pediatric-onset demyelinating diseases
The purpose of this research study is to better understand how the brains of children and young adults with demyelinating diseases, such as multiple sclerosis (MS), change over time. The main goal is to track changes in the size and structure of the brain using brain scans called Magnetic Resonance Imaging(MRI) scans that are analyzed by a software called Icometrix that measures the size and structure of different regions in the brain (“volumetrics software”). By looking at these changes, the researchers want to see if they can find any links between brain changes and how the disease affects the subject’s abilities, thinking, and overall health over time. This study will also look for possible signs (called biomarkers) that could help doctors predict or understand these brain changes to help better manageand treat these diseases in children.
A Single-Center Observational Study to Develop EEG Biomarkers of Transition from Acute to Chronic Pain
We will enroll acute and chronic low back pain and control subjects. We will record high density EEG in these subjects, along with pain and mood questionnaires. Those with acute pain will be followed longitudinally with additional visits at 1, 3, and 6 months. We will use machine learning to develop and validate a biomarker for the transition from acute to chronic pain.