KontRASt-03: A Phase Ib/II multicenter open-label platform study of JDQ443 with select combinations in patients with advanced solid tumor harboring the KRAS G12C mutation
This study will focus on two types of cancer: non-small cell lung cancer and colorectal cancer. The purpose of the study is to find out if a drug called JDQ443 (a type of experimental, oral drug that can target a specific protein called KRASG12C) is safe and effective for treating solid tumors with a specific genetic mutation called KRAS G12C. They will test JDQ443 with other treatments in adult patients. The study has two parts: Phase Ib and Phase II. In Phase Ib, they will test different doses of JDQ443 with other treatments to see what combination of treatments works best and what doses of the treatments have few side effects. In Phase II, they will test the dose that is most effective of JDQ443 with other treatments to see how well it works to fight cancer and if it has few side effects for patients.
Labor & Delivery for Pregnancy | NYU Langone Health
NYU Langone doctors and nurses guide women through the labor and delivery process.
Language & Disability Services | NYU Langone Health
NYU Langone provides interpretation and translation services, as well as assistance for people with disabilities.
Laryngeal Cancer | NYU Langone Health
Cancer Center doctors use surgery, radiation therapy, and chemotherapy to manage laryngeal cancer.
Laser Therapy & Dermabrasion for Aging Skin | NYU Langone Health
NYU Langone skin specialists use laser therapies and dermabrasion to smooth wrinkles and lines associated with aging skin.
Laser Therapy for Glaucoma | NYU Langone Health
NYU Langone eye specialists may recommend laser therapy to manage glaucoma.
Laser Treatment Services | NYU Langone Health
NYU Langone’s plastic surgery team provides laser skin resurfacing and laser vaginal rejuvenation.
Lateral Skull Base Surgery Program | NYU Langone Health
NYU Langone’s Lateral Skull Base Surgery Program treats people of all ages with hearing, cranial nerve, and skull base tumors or conditions.
Lateral Skull Base Surgery Program Doctors | NYU Langone Health
Find a doctor at the Lateral Skull Base Surgery Program at NYU Langone.
Latino Liver Program | NYU Langone Health
NYU Langone’s Latino Liver program provides medically advanced, culturally conscious care to Hispanic and Latino/a/x children and adults.
