EMBER-4: A Randomized Open-Label Phase 3 Study of Adjuvant Imlunestrant vs Standard Adjuvant Endocrine Therapy in Patients who have Previously Received 2 to 5 years of Adjuvant Endocrine Therapy for ER+ HER2- Early Breast Cancer with an Increased Risk of Recurrence
EMBER-4 is a Phase 3 global, randomized, open-label study of adjuvant imlunestrant vs SOC adjuvant ET of physician’s choice in participants who have previously received 2 to 5 years of standard ET for ER+, HER2- EBC (Stages I-III) with an increased risk of recurrence. Eligible participants must have completed definitive locoregional therapy, received 2 to 5 years of standard adjuvant ET without disease recurrence, and must have an increased risk of recurrence based on clin-path features at diagnosis, as defined in the inclusion criteria (Protocol Section 5.1). Participants may have received (neo) adjuvant chemotherapy and/or targeted therapy with a CDK4/6- or PARP- inhibitor. Participants may not have had a gap of 6 consecutive months during the SOC ET treatment and should not have stopped SOC ET more than 6 months prior to randomization. The study will consist of a 28-day screening phase, followed by a 5-year treatment phase, and a 5-year posttreatment phase, which will include safety, efficacy, and survival follow-up assessments.Physician’s choice ET (tamoxifen or an AI) must be selected and documented for each participant prior to randomization. Participants will be randomized using the following stratification factors: 1. Time from start of initial adjuvant ET to initiation of study treatment (2 to =3 years vs >3 to 5 years)2. Received prior adjuvant CDK4/6 inhibitor treatment (yes vs no)3. Nodal status (=N2 vs N1 vs N0)a4. Menopausal status (pre-/peri-menopausal vs postmenopausal)b5. Region (North America/Europe vs Asia vs Other)
Embolization for Liver Cancer & Liver Metastases | NYU Langone Health
NYU Langone’s Perlmutter Cancer Center doctors may use embolization to deliver chemotherapy or radiation directly to liver tumors.
Embryo, Egg & Sperm Storage Fees | NYU Langone Health
Get information on embryo, egg, and sperm storage fees at the NYU Langone Fertility Center.
Emergency Care | NYU Langone Health
NYU Langone offers emergency and urgent care at a variety of locations in Manhattan and Brooklyn, as well as Virtual Urgent Care.
Emergency Care for Children | NYU Langone Health
Several locations of Hassenfeld Children’s Hospital at NYU Langone offer emergency care for children.
Emergency Department at NYU Langone Hospital—Brooklyn | NYU Langone Health
The Emergency Department at NYU Langone Hospital—Brooklyn specializes in trauma, stroke, and acute cardiac care.
Emergency Department at NYU Langone Hospital—Long Island | NYU Langone Health
Care providers in the Emergency Department at NYU Langone Hospital—Long Island specialize in trauma, stroke, and acute cardiac care.
Emergency Department at NYU Langone Hospital—Suffolk | NYU Langone Health
The Emergency Department at NYU Langone Hospital—Suffolk provides trauma, stroke, and acute cardiac care for the people of eastern Long Island.
Emotional Support for Children | NYU Langone Health
At Hassenfeld Children’s Hospital at NYU Langone, we support children and families as they cope with emotional concerns about medical care.
Employment Characteristics of Epilepsy Patients
The main objectives of the study are to characterize employment among individuals with a diagnosis of epilepsy, examining their employment and compensation characteristics as well as the real and perceived barriers to full workplace participation which may be directly or indirectly related to their seizures. This information may help patients, their caregivers, physicians, and policymakers to understand the barriers to workplace participation.