Non-Hodgkin Lymphoma in Children | NYU Langone Health
Specialists at Hassenfeld Children’s Hospital at NYU Langone diagnose and treat childhood non-Hodgkin lymphoma.
Non-invasive biomarkers for neonatal outcomes in preterm infants
Despite modern advances that have greatly improved the health outcomes for preterm infants, the field of neonatology still lacks reliable prognostic tools for many disorders. Noninvasively-obtained samples (such as blood, trach aspirate, urine, saliva and stool samples) contain a wealth of biologic information in the form of DNA, RNA, proteins, and metabolites that can predict neonatal outcomes. Exosomes are small, membrane-bound extracellular vesicles (EVs) that are released by a variety of cells and involved in several cell-to-cell communication pathways. A proposed mechanism by which exosomes mediate cell signaling is via microRNAs (miRNAs), which are small, non-coding RNA segments that silence complementary messenger RNA (mRNA) segments. While exosomes have been characterized in biofluids from adults, few studies have examined the diagnostic value of biofluid exosomes.The objective of this study is to determine whether exosomes can be isolated from neonatal blood, urine, trach aspirate, saliva and stool samples, and if so, whether specific biomarkers (such as exosomal miRNAs) are associated with distinct neonatal pathologies such as chronic lung disease of prematurity (BPD: Bronchopulmonary dysplasia) or other neonatal inflammatory conditions. This is significant because findings could revolutionize the way preterm infants in neonatal intensive care units (NICUs) are monitored at the bedside. This exploratory, prospective study will be conducted with samples collected from the NYU Winthrop Hospital NICU. Specifically, we will measure biomarkers from non-invasive samples (Blood, urine, saliva and stool samples) in two groups; 1) preterm infants
Non-Invasive Salivary Biomarkers in Full Term Neonates
Despite modern advances that have greatly improved the health outcomes for infants, the field of neonatology still lacks reliable prognostic tools for many disorders. Non-invasively-obtained samples (such as saliva) contains a wealth of biologic information in the form of DNA, RNA, proteins, and metabolites that can predict neonatal outcomes. Exosomes are small, membrane-bound extracellular vesicles (EVs) that are released by a variety of cells and involved in several cell-to-cell communication pathways. A proposed mechanism by which exosomes mediate cell signaling is via microRNAs (miRNAs), which are small, non-coding RNA segments that silence complementary messenger RNA (mRNA) segments. While exosomes have been characterized in biofluids from adults, few studies have examined the diagnostic value of these biofluid exosomes.The objective of this study is to determine whether exosomes can be isolated from full-term neonatal saliva samples, and if so, whether specific biomarkers (such as exosomal miRNAs) can be further characterized. This is significant because findings could suggest ways to measure biomarkers non-invasively in neonates.This exploratory, prospective study will be conducted with samples collected from the NYU Langone – Long Island Outpatient Pediatric Clinic. Specifically, we will measure biomarkers from non-invasive samples (saliva) in full-term infants >37 weeks gestation (n=40) who were never admitted to the Neonatal Intensive Care Unit. Neonates can be enrolled in the first week of life at their first well-baby visit to the Pediatric Clinic. Samples will then be collected at every routine well-baby visit starting in the 2nd week for the first 4 weeks of life. Mouth suctioning to collect saliva samples will be performed specifically for research. All samples will be transported to the PI’s laboratory and processed for experimentation. The biomarkers examined in the lab will then be correlated to neonatal clinical outcomes obtained via medical record review.
Non-Small Cell Lung Cancer | NYU Langone Health
Doctors at NYU Langone’s Perlmutter Cancer Center diagnose and treat people who have non-small cell lung cancer.
Non-Small Cell Lung Cancer Diagnosis | NYU Langone Health
Doctors at NYU Langone’s Perlmutter Cancer Center use advanced imaging tests and various procedures to diagnose non-small cell lung cancer.
Non-Small Cell Lung Cancer Screening | NYU Langone Health
Doctors at NYU Langone’s Perlmutter Cancer Center provide regular screening for people at high risk for lung cancer.
Non-Small Cell Lung Cancer Surgery | NYU Langone Health
Doctors at NYU Langone’s Perlmutter Cancer Center may use surgery to remove early non-small cell lung cancer.
Nonhealing Fractures | NYU Langone Health
NYU Langone specialists offer expert diagnosis and care to help people who have nonhealing fractures heal as quickly as possible.
Noninvasive Cardiac Imaging & Testing | NYU Langone Health
Cardiologists at NYU Langone Heart use ultrasound imaging to diagnose and manage heart-related conditions.
Noninvasive Cardiac Imaging & Testing Doctors | NYU Langone Health
Find a doctor at the Noninvasive Cardiac Imaging & Testing at NYU Langone.