Intradialytic Myocardial Study Stunning in Maintenance Hemodialysis Patients: A Multi-Center Observational Cohort Study
The purpose of this observational study is to prospectively investigate the frequency and risk factors for intermittent intradialyltic myocardial stunning (IDMS) in maintenance hemodialysis patients, to evaluate the prevalence of repetitive IDMS, and to investigate the role of cardiovascular autonomic control in IdMS pathophysiology using a battery of autonomic function tests during dialysis and on non-dialysis daysAll subjects will undergo pre- and intradialytic transthoracic echocardiography during a single hemodialysis session. There will be four substudies:• Substudy A—a subset of participants will undergo repeat scanning during a 2nd session to assess the frequency of repetitive IDS• Substudy B—a subset of participants will undergo intradialytic testing of autonomic function during a single hemodialysis session during the baseline echocardiography scanning• Substudy C—a subset of participants will undergo autonomic function testing on a non-dialysis day• Substudy D—a subset of participants will undergo myocardial sympathetic PET scanning in order to assess myocardial uptake of neuro-sympathetic hormones
Intraocular Melanoma in Adults | NYU Langone Health
Perlmutter Cancer Center specialists offer expert care for people with intraocular melanoma, or choroidal melanoma, a cancer that begins in the eye.
Intraoperative recording and stimulation to map language and cognition
The purpose of this study is to investigate the brain functions underlying cognition by combining experimental tasks and stimulation during neurosurgery. Study procedures involve a brief neural task (~20 minutes) that may involve speaking into a microphone to understand how brain activity is affected by things like language, movement, and information from our senses. The study will investigate what happens in the brain during these activities, and then map these patterns.
Intrathecal Therapy for Acute Myeloid Leukemia | NYU Langone Health
NYU Langone doctors may recommend intrathecal therapy to destroy leukemia cells for people with acute myeloid leukemia.
Intrathecal Therapy for Leukemia in Children | NYU Langone Health
Doctors at Hassenfeld Children’s Hospital recommend intrathecal therapy to protect the central nervous system during chemotherapy for acute childhood leukemia.
Intrathecal Therapy for Non-Hodgkin Lymphoma in Children | NYU Langone Health
Doctors at Hassenfeld Children’s Hospital at NYU Langone use intrathecal therapy to protect the central nervous system during chemotherapy.
Intravenous Treatment for Sepsis in Children | NYU Langone Health
At Hassenfeld Children’s Hospital at NYU Langone, children with sepsis receive IV treatments to combat infection and symptoms.
Intravesical Therapy for Bladder Cancer | NYU Langone Health
Doctors at NYU Langone’s Perlmutter Cancer Center may use intravesical immunotherapy or intravesical chemotherapy to treat bladder cancer.
Investigating auditory processing in the users of auditory brainstem and cochlear implants
This is a basic investigational research study conducted with hearing impaired adults and children who use cochlear implant or auditory brainstem implant (ABI) devices. The study will evaluate different aspects of hearing and auditory processing in the users of implantable auditory devices.
Investigating the Temperature Dependence of Age-related Tau Pathology Relevant to Early Alzheimer's Disease
This is a cross-sectional study in 100 older adults (n = 100, 50 female, 60–80 years) who are cognitively normal (n = 70) or have mild cognitive impairment (n = 30). The purpose is to test whether features of body temperature (Tb), measured with ingestible telemetry, are associated with tau pathology, measured with [18-F]-MK-6240 tau PET-MR and plasma P-tau. Participant involvement includes 6 study visits over a period of 4 months. The duration of the project is 5 years. Briefly, subjects who express interest and are eligible for screening based on a pre-screening call will undergo in-person medical screening and complete several intake questionnaires at Visit 1, followed by a blood draw at CTSI, a clinical interview and neuropsychological testing at Visit 2. A 7-day at-home sleep assessment and actigraphy data, after Visit 2, will help us determine sleep-wake cycles and screen for Obstructive Sleep Apnea which is exclusionary for our study, if severe. At Visits 3 & 4, subjects will undergo body temperature measurements with ingestible telemetric thermometry over 48 hours, commencing on Night 1 of a 48 hour visit to the MSCIC sleep lab. Sleep EEG characteristics will be assessed with polysomnography on Nights 1 and 2 of this 48 hour period. During the day between these nights, subjects will be free to return home. After sleep study data is analyzed, the Eligibility Checklist can be completed. At Visit 5 which will take place at least 7 days after the sleep study completion, subjects will undergo a Tau PET/MR scan at the Center for Biomedical Imaging. At Visit 6, at least 7 days after the sleep study (but not on the same day as the Tau PET/MR) subjects will undergo an amyloid PET/MR scan. The purpose of the PET/MR scans is to control for tau and amyloid burden in the central nervous system.This cross-sectional study will lay the ground work for future prospective studies to determine whether Tb based interventions can prevent the progression of NFT pathology toward reducing Alzheimer’s Disease burden.