Susan Logan, Ph.D.

Susan LoganAssistant of Urology and Pharmacology
Departments of Urology and Pharmacology

Research Overview

Lab Mission

The mission of the Logan laboratory is to understand what causes prostate cancer and to identify cellular and molecular events that propagate aggressive disease. It is our hope that understanding the biology of the disease will contribute to the development of new therapies and eradication of prostate cancer as a life-threatening illness.

Lab members

Focus

The focus of the lab is on the androgen steroid hormone receptor, which plays an integral role in the development of prostate cancer. Some of the questions we are currently asking include the following:

  • What are the components of the androgen receptor–containing transcription complexes, and how do these regulate genes in prostate cancer cells?
  • How does the androgen receptor talk to other cellular signaling pathways in normal cells and prostate cancer cells?
  • How does modification of the androgen receptor affect prostate cell growth?

Methodology

The lab uses a variety of techniques to understand the biology of prostate cancer.

  • We have generated a variety of phosphorylation site–specific antibodies for use in immunohistochemistry in human prostate cancer specimens to begin to understand how androgen receptor signaling may differ in different stages of prostate cancer, and from one individual to another.
  • Transgenic and knockout mouse models are used to evaluate the impact of other proteins on androgen receptor function and tumor growth.
  • Biochemical techniques are used to characterize proteins in androgen receptor–containing transcription complexes.
  • A variety of cell biological techniques are used to examine the subcellular localization of the androgen receptor and interacting proteins in response to signaling pathways aberrantly activated in tumors.
  • The impact of proteins and treatments on gene transcription are examined in prostate cancer cells by gene expression array, shRNA technology and chromatin immunoprecipitation (ChIP).

Integration

We hope that the variety of approaches taken in the lab will clarify the means by which prostate cancers thrive in a given microenvironment.

Publications

Contact information