Gregg J. Silverman, M.D.

Dr. Silverman

Professor of Medicine and Pathology
Head, Laboratory of B-cell Immunobiology
Email: Gregg.Silverman@nyumc.org

Clinical and Research Interests

  • Rheumatoid arthritis
  • Systemic lupus erythematous
  • Protective natural antibodies
  • Human –microbiome relationship
  • B-cell superantigens
  • B cell repertoires in health and disease
  • Microbiome and autoimmunity
  • Host response to staphylococcus aureus

Dr. Silverman has studied B cell immunobiology and autoimmunity since the start of his fellowship at the Scripps Research Foundation in 1985. Working in the laboratory of Prof. Dennis Carson, these studies initially focused on clinical samples with monoclonal Rheumatoid factors from the laboratory of Henry Kunkel (Rockefeller Institute), the father of modern clinical immunology and the analysis of antibody gene usage in human rheumatoid factors from patients with essential mixed cryoglobulinemia, Hepatitis C, Rheumatoid Arthritis, and Sjogrens syndrome. These studies evolved into investigations of the human B-cell repertoire, B-cell superantigens, and more recently the interplay between the microbiome and host immunity.

In collaborative studies with the laboratory of Joseph Witztum (UC San Diego), we have developed insights into the immunomodulatory properties of B-cells as producers of protective autoantibodies to apoptotic cell membrane determinants that may oppose the development of inflammatory and autoimmune diseases. Recent investigations in the human gut microbiome has led to the identification of a candidate pathobiont, linked to the pathogenesis of Lupus nephritis, a major cause of morbidity and mortality.

Since the early 1990’s , Dr. Silverman has also directed an annual course of phage display and recombinant antibody technology at Cold Spring Harbor Labs, which most recently has celebrated the 2018 Noble Prize of Prof. George Smith, the inventor of phage display technology.

Dr. Silverman is also a practicing rheumatologist with a special interest in caring for patients with lupus, rheumatoid arthritis, and related conditions. After more than two decades on the faculty at UCSD, in 2011 Dr. Silverman moved to NYU School of Medicine where he continues to lead an NIH funded basic and translational research group.

Education and Training

1977

Brandeis University, Massachusetts, B.A., cum laude Biochemistry COSTEP Fellow, NIH Clinical Center, Bethesda, MD, NCI 1978, NIAID 1979

1981

UMDNJ-Rutgers Medical School, New Jersey, M.D.

1981 - 1984

Intern and Resident in Medicine, University Hospital, San Diego, California

1985 - 1987

Clinical Fellow in Division of Rheumatology, Scripps Clinic and Research Foundation, La Jolla, California

1985 - 1987

Research Fellow in the Division of Clinical Immunology, Department of Basic and Clinical Research, Scripps Clinic and Research Foundation

1986

Chief Clinical Fellow, Scripps Clinic and Research Foundation

1988 - 1990

Senior Research Associate, Division of Clinical Immunology, Department of Basic and Clinical Research, Scripps Clinic and Research Foundation

1990 - 2001

Adjunct Assistant Member, Department of Molecular and Experimental Medicine, Scripps Clinic and Research Foundation

1990

Assistant Professor, Department of Medicine, University of California, San Diego, La Jolla, CA

1996

Associate Professor, Department of Medicine, University of California, San Diego

2002

Adjunct Associate Member, Department of Molecular and Experimental Medicine, The Scripps Research Institute

2002 - 2011

Professor, Department of Medicine, University of California, San Diego

2006 –

 

2011-

Adjunct Member, Department of Molecular and Experimental Medicine, The Scripps Research Institute

Professor with Tenure, Departments of Medicine and Pathology, New York University School of Medicine, NY,

Societies and Honors

  • Alpha Omega Alpha, 1980
  • American College of Rheumatology - Fellow
  • American Association of Immunologists
  • Henry Kunkel Society, Rockefeller University - 2000
  • American Society for Clinical Investigation, Member – 2001

Licenses And Boards

  • California Board of Medical Quality Assurance
  • American Board Internal Medicine
  • American Board Internal Medicine Rheumatology subspecialty
  • New York State Licensure, Medicine and Surgery

View Dr. Silverman's Publications