Led by Gregg Silverman, MD, B-cell Immunobiology Lab is part of the Department of Medicine and the Division of Rheumatology. Our research group has focused on investigations of the body’s capacity to produce antibodies in health and in disease, and how these antibodies coordinate the functions of the overall immune system. We have been especially interested in better understanding the disease pathways in rheumatoid arthritis, and our recent studies have led us to also investigate the potential influence of the gut microbiome on the archetypic autoimmune disease, systemic lupus erythematosus.

The lab currently utilizes a broad range of technologies. For the generation of well-characterized monoclonal antibodies, we have applied phage-display protein bioengineering technology, and prokaryotic expression systems. In addition, for large-scale production we have made recombinant IgG antibodies in bioreactor systems.

To characterize the binding specificity of in vivo antibody responses, we have developed printed autoantigen microarrays and also multiplex bead-based assays. We have also used in vitro culture systems to identify the functional properties of antibody-based agents to assess responses in cell lines and primary cells. To investigate relevance to disease states, we are also exploring in vivo model inflammation systems using purified agonists for Toll-like receptors and other receptor molecules within the innate immune system and murine models of inflammatory arthritis, lupus, and other conditions. As our ultimate goal is to develop better therapeutic agents, we study clinical samples from patients to understand the relevance of our investigations to human immune responses.

Since joining the NYU School of Medicine in 2011, we have initiated studies of the effects of the gut microbiome in mice and humans on B-cell responses in autoimmune disease, and we are also investigating B-cell responses during infections to Staphylococcus aureus.

Contact Us

Gregg Silverman, MD
Principal Investigator
The Mamdouha S. Bobst Professor of Internal Medicine, Department of Medicine
Professor, Departments of Medicine and Pathology
NYU Grossman School of Medicine
New York, NY 10016
Office: 212-263-9440
Email: Gregg.Silverman@NYULangone.org

Tyler Weinstein
Project Coordinator
Office: 212-263-9421
Email: Tyler.Weinstein@NYULangone.org