Center for the Investigation of Environmental Hazards Pilot Project Program | NYU Langone Health

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Center for the Investigation of Environmental Hazards Center for the Investigation of Environmental Hazards Pilot Project Program

Center for the Investigation of Environmental Hazards Pilot Project Program

The goal of the Pilot Project Program is to support NYU Langone’s Center for the Investigation of Environmental Hazards by funding promising research initiatives that align with the National Institute of Environmental Health Sciences (NIEHS) mandate as well as the strategic plans of our center to generate preliminary data that will help in establishing strong research programs and obtaining extramural funding.

The Pilot Project Program aims to encourage and aid new investigators who wish to establish independent research careers in environmental health sciences (EHS), motivate non-EHS researchers to direct their expertise toward environmental health problems, develop robust clinical and translational research programs by promoting interactions between basic scientists and physician–scientists, and promote interdisciplinary research by fostering collaborations between EHS investigators and experts in cutting-edge technologies.

The program supports research in diverse areas of EHS including air pollution, metal toxicity, endocrine-disrupting chemicals, DNA damage and repair, environmental epigenetics, and multiomics studies on hazardous environmental exposures. In addition, the program addresses the concerns of the Ramapough Lenape Tribal Nation in New York and New Jersey, as well those of people in the Brooklyn neighborhoods of Sunset Park, Gowanus, and Red Hook, environmentally impacted communities that surround Superfund sites.

Program Leadership

Suresh Cuddapah, PhD, is director of the Pilot Project Program.

Request for Applications

The center’s leadership (with recommendations from the Internal Advisory Committee) issues and publicizes requests for applications (RFAs) every year. This may include RFAs that address emerging environmental health issues. The RFAs emphasize interdisciplinary collaborations, clinical and translational research, and utilization of the expertise and technologies available in the center’s various facility cores. The funding is limited to 12 months for a maximum award of $40,000 (direct costs).

Funding Eligibility

Postdoctoral fellows and faculty members working in the area of EHS at all NYU schools are eligible. Applications are particularly encouraged from early stage investigators. Community partner members are also eligible to apply for Pilot Project Program funding to work in collaboration with primary center members.

Funding Application Review

We request that applicants submit a one-page letter of intent. Letters are reviewed by the center leadership’s ad hoc committee, and selected applicants are then asked to submit a full application, including a research proposal.

The submitted research proposal is reviewed by one expert within NYU or NYU Langone and two external reviewers. Reviewers follow National Institutes of Health (NIH) grant review guidelines to evaluate and score the proposals. In addition, reviewers comment on the potential of the applications to obtain future extramural funding.

Upon receipt of the reviewers’ critiques, an ad hoc committee consisting of center leadership discusses the proposals in an NIH study section–like meeting and makes funding decisions. Criteria for funding include overall impact score, potential to obtain extramural funding, and the relevance of the proposal to NIEHS goals and our center’s strategic growth plan.

Recently Awarded Pilot Projects

The following are our recently awarded pilot projects.

2019–20 Pilot Projects

Studies of Organophosphate Esters, Emerging Flame Retardants, in a New York City–Based Pregnancy Cohort

Potential Environmental Influences on Postpartum Depression

Effects of Perfluoroalkyl Compounds (PFAS) and Xenobiotic Metals Including Lead and Cadmium on Severity of Ischemic Myocardium and Coronary Atherosclerosis

Evaluation of the Influence of Organophosphate Pesticides in Semen Quality in Men

Measurement of Reproducibility of PFAS Exposures in Annual from Premenopausal and Postmenopausal Women

Quantification of Cargo in Extracellular Vesicles and Their Relationship to Air Pollution Exposures

Examination of Skeletal Development in Fetal Mice Prenatally Exposed to Hexavalent Chromium

Case Control Study of PFAS and PCBs in Pancreatic Cancer

2018–19 Pilot Projects

Regulation of RUNX2 and miRNA During Ni and As Carcinogenesis

Investigation of Mechanisms Underlying Persistent Transcriptional Alterations by Nickel Exposure

Chromium Carcinogenicity Caused by Chromosomal Instability

Novel Discovery of p62 in Nickel-Induced TNFα Expression and Transformation in Human Bronchial Epithelial Cells

2017–18 Pilot Projects

E-cigarette Smoke Induces DNA Damage and Repair Inhibition and Prevention Effect of Polyphenols in Mouse Models

The Role of Histone Variant H3.3 in Maintaining Active Chromatin Status Induced by Environmental Exposure

Effects of Electronic Cigarette Exposures During Pregnancy and Early Life: What Can We Learn From Mice?

Using a Lung-on-a-Chip In Vitro Exposure Model to Investigate the Adverse Effects of Alternative Tobacco Products

2016–17 Pilot Projects

Chromium Carcinogenicity Caused by Chromosomal Instability

Atg7 and Autophagy in Bladder Cancer Invasion

Characterization of Cr(VI)-Induced Sumoylation of Histone Acetyltransferase hMOF

Nickel Exposure Induces Epithelial-Mesenchymal Transition Through Stable Transcriptional Alterations

The Ramapough Tribe: An Environmentally Impacted Nation in Need

Contact Us

For more information, contact Dr. Cuddapah at suresh.cuddapah@nyulangone.org.