Guillaume Madelin

Guillaume Madelin, PhD

Associate Professor, Department of Radiology

Keywords
Magnetic Resonance Imaging (MRI), X-Nuclei (Sodium, Phosphorus, Deuterium, Oxygen) MRI, Metabolic Imaging, Non-Cartesian MRI, Ultrashort Echo Time (UTE) MRI, Neuroimaging, Musculoskeletal Imaging, Cancer Imaging, MR Physics
Summary

I am developing methodologies for quantitative metabolic X-nuclei magnetic resonance imaging (MRI) in humans in vivo.

X-nuclei MRI is based on the detection of nuclei other than the nucleus of hydrogen (or proton, 1H) from water molecules in the body, as is used in standard MRI. MRI of the sodium (23Na), phosphorus (31P), deuterium (2H), or oxygen (17O) nuclei, for example, can provide brand new metabolic information in tissues as a complement to standard structural 1H MRI. In particular, imaging of the endogenous Na+ ion content and relaxation properties with MRI can help assess fundamental biochemical information related to tissue ionic homeostasis and cellular energetic metabolism, which are not available with other imaging technique in vivo.

Overall, X-nuclei MRI could therefore generate unique imaging biomarkers for detecting early signs of loss of tissue viability due to the disruption of the cellular metabolism in many diseases, but also for monitoring the early effects of therapies targeting different aspects of this cellular metabolism.

Phone

212-263-3343

Academic office

Center for Biomedical Imaging, 660 First Avenue

4th Floor

New York, NY 10016

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Positions

Associate Professor, Department of Radiology at NYU Grossman School of Medicine

Graduate Education

PhD from University of Bordeaux

Quadri-Nuclear MRI to Study Brain Energy Metabolism

Single-center observational longitudinal study to identify predictors of progression of joint damage after non-contact rupture of anterior cruciate ligament

Simultaneous Multinuclear Magnetic Resonance Fingerprinting for Data Fusion of Quantitative Structural and Metabolic Imaging

Biological and Imaging Markers to Understand and Predict Progression of Joint Damage after Injury

See All Studies (5)

Triple-tuned birdcage and single-tuned dipole array for quadri-nuclear head MRI at 7 T

Paška, Jan; Wang, Bili; Chen, Anna M; Madelin, Guillaume; Brown, Ryan

Magnetic resonance in medicine. 2024 May; 91(5):2188-2199

Longitudinal changes in sodium concentration and in clinical outcome in mild traumatic brain injury

Gerhalter, Teresa; Chen, Anna M; Dehkharghani, Seena; Peralta, Rosemary; Gajdosik, Mia; Zarate, Alejandro; Bushnik, Tamara; Silver, Jonathan M; Im, Brian S; Wall, Stephen P; Madelin, Guillaume; Kirov, Ivan I

Brain communications. 2024 Jul; 6(4):fcae229

Super-resolution of sodium images from simultaneous 1 H MRF/23 Na MRI acquisition

Rodriguez, Gonzalo G; Yu, Zidan; Shaykevich, Sarah; O'Donnell, Lauren F; Aguilera, Liz; Cloos, Martijn A; Madelin, Guillaume

NMR in biomedicine. 2023 Apr 25; e4959

Replicability of proton MR spectroscopic imaging findings in mild traumatic brain injury: Implications for clinical applications

Chen, Anna M; Gerhalter, Teresa; Dehkharghani, Seena; Peralta, Rosemary; Gajdošík, Mia; Gajdošík, Martin; Tordjman, Mickael; Zabludovsky, Julia; Sheriff, Sulaiman; Ahn, Sinyeob; Babb, James S; Bushnik, Tamara; Zarate, Alejandro; Silver, Jonathan M; Im, Brian S; Wall, Stephen P; Madelin, Guillaume; Kirov, Ivan I

NeuroImage: Clinical. 2023 Jan 19; 37:103325

Quadrupolar 23Na+ NMR relaxation as a probe of subpicosecond collective dynamics in aqueous electrolyte solutions

Chubak, Iurii; Alon, Leeor; Silletta, Emilia V; Madelin, Guillaume; Jerschow, Alexej; Rotenberg, Benjamin

Nature communications. 2023 Jan 05; 14(1):84

Repeatability of simultaneous 3D 1H MRF/23Na MRI in brain at 7 T

Rodriguez, Gonzalo G; Yu, Zidan; O Donnell, Lauren F; Calderon, Liz; Cloos, Martijn A; Madelin, Guillaume

Scientific reports. 2022 Aug 19; 12(1):14156

Simultaneous 3D acquisition of 1 H MRF and 23 Na MRI

Yu, Zidan; Hodono, Shota; Dergachyova, Olga; Hilbert, Tom; Wang, Bili; Zhang, Bei; Brown, Ryan; Sodickson, Daniel K; Madelin, Guillaume; Cloos, Martijn A

Magnetic resonance in medicine. 2022 May; 87(5):2299-2312

X-Nuclei Magnetic Resonance Imaging

Madelin, Guillaume

X-Nuclei Magnetic Resonance Imaging. [S.l.] : Jenny Stanford Publishing, 2022. 1st ed. (5181842)

See All Publications (64)