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Jiangyang Zhang

Jiangyang Zhang, PhD

Associate Professor, Department of Radiology

Keywords
high-resolution MRI, diffusion MRI, brain structure, development, imaging, brain injury
Summary

One of my research interests is to develop diffusion magnetic resonance micro-imaging techniques to examine tissue microstructures as well as computational techniques to quantify the observed changes during development and injury. The techniques are useful to characterize abnormal brain development due to genetic mutations and structural abnormalities due to injuries. Based on these techniques, we have established a mouse brain atlas based on diffusion tensor imaging. In my early publications, my work was mainly dealing with post-mortem samples. In recent years, we have developed new techniques for in vivo diffusion MRI of the mouse brains. Recently, we have published papers on in vivo diffusion magnetic resonance micro-imaging of the adult mouse brain and in utero diffusion MRI of the embryonic mouse brain.

While diffusion MRI has shown great potential in detecting white matter injuries, the relationships between tissue pathology and diffusion MRI signals are still not fully understood. Using mouse models of neonatal hypoxia ischemia, multiple sclerosis, and Hungtington’s diseases, I have studied the relationships and characterize the disease progression and treatment efficacy.

Since 2009, I have worked on the new oscillating gradient diffusion MRI technique. The technique uses oscillating gradient waveforms to achieve very short diffusion time previously difficult to reach using conventional pulsed gradient diffusion MRI sequences. With diffusion MRI measurements obtained at very short diffusion times, it is possible to distinguish tissue microstructures based on their spatial scales. The technique has a long history and several groups have made significant contributions to its development. We are the first to report new tissue contrasts, both in normal and injured brains, that are not available from conventional diffusion MRI and provide additional information on tissue microstructures, e.g. cell swelling after hypoxia ischemia injury.

Phone

212-263-3349

Academic office

660 First Ave

4th Fl

new York, NY 10016

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PhD from Johns Hopkins University

Lee, Choong Heon; Walczak, Piotr; Zhang, Jiangyang

Magnetic resonance in medicine. 2022 Jul; 88(1):332-340

Wu, Dan; Richards, Linda J; Zhao, Zhiyong; Cao, Zuozhen; Luo, Wanrong; Shao, Wei; Shi, Song-Hai; Miller, Michael I; Mori, Susumu; Blackshaw, Seth; Zhang, Jiangyang

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2022 02 15; 119(7):

Liang, Zifei; Lee, Choong H; Arefin, Tanzil M; Dong, Zijun; Walczak, Piotr; Hai Shi, Song; Knoll, Florian; Ge, Yulin; Ying, Leslie; Zhang, Jiangyang

eLife. 2022 01 28; 11:

Li, Hongyu; Liang, Zifei; Zhang, Chaoyi; Liu, Ruiying; Li, Jing; Zhang, Weihong; Liang, Dong; Shen, Bowen; Zhang, Xiaoliang; Ge, Yulin; Zhang, Jiangyang; Ying, Leslie

Magnetic resonance in medicine. 2021 Dec; 86(6):3334-3347

Arefin, Tanzil Mahmud; Lee, Choong Heon; White, Jordon D; Zhang, Jiangyang; Kaffman, Arie

Bio-protocol. 2021 Nov 20; 11(22):e4221

Georgiadis, Marios; Schroeter, Aileen; Gao, Zirui; Guizar-Sicairos, Manuel; Liebi, Marianne; Leuze, Christoph; McNab, Jennifer A; Balolia, Aleezah; Veraart, Jelle; Ades-Aron, Benjamin; Kim, Sunglyoung; Shepherd, Timothy; Lee, Choong H; Walczak, Piotr; Chodankar, Shirish; DiGiacomo, Phillip; David, Gergely; Augath, Mark; Zerbi, Valerio; Sommer, Stefan; Rajkovic, Ivan; Weiss, Thomas; Bunk, Oliver; Yang, Lin; Zhang, Jiangyang; Novikov, Dmitry S; Zeineh, Michael; Fieremans, Els; Rudin, Markus

Nature communications. 2021 05 19; 12(1):2941

White, Jordon D; Arefin, Tanzil M; Pugliese, Alexa; Lee, Choong H; Gassen, Jeff; Zhang, Jiangyang; Kaffman, Arie

eLife. 2020 12 01; 9:

Gao, Fusheng; Shen, Xiaoxia; Zhang, Hongxi; Ba, Ruicheng; Ma, Xiaolu; Lai, Can; Zhang, Jiangyang; Zhang, Yi; Wu, Dan

Journal of cerebral blood flow & metabolism. 2020 Aug 18; 271678X20944353