In vivo localized MR spectroscopy (MRS) facilitates non-invasive investigations of the physiology and biochemistry (as opposed to the anatomic and morphologic information from MRI). The primarily focus of our research is the human brain, and to a lesser extent, other organs, e.g., the liver and pancreas, probed by 3-dimensional localized proton (but also phosphorus-31 and fluorine-19) MRS. An example of the differences and similarities between MRI and MRS is illustrated in the figure below. Our research projects propagate along three, parallel paths: First, technique development - the design of new localization methods, based on Fourier and Hadamard spatial encoding, to accommodate the higher magnetic fields that are now becoming available, and to tailor these methods to anatomies that traditionally have been inaccessible to existing methodologies, e.g., the spinal cord, optic nerve and cortex. Second, application of these methods to characterize normal and pathological metabolism by quantitatively comparing metabolic levels in the different anatomical structures. Our current clinical focuses are the processes of normal aging, multiple sclerosis and traumatic brain injury. Finally, the third direction is post- processing and visualization methodology and software development, to display the copious 3D information in a manner that will not hide the forest for the trees, because, after all, this is a department of radiology, so here, image is everything.
Professor, Department of Radiology
Professor, Department of Neuroscience and Physiology
PhD from Hebrew University of Jerusalem
NMR in biomedicine. 2017 Jul 5; ?-?
Human brain mapping. 2017 May 19; 38(8):4047-4063
AJNR. American journal of neuroradiology. 2017 May 11; 38(6):1117-1121
Radiology. 2017 May 10; 161216-161216
Magnetic resonance imaging. 2017 Jan; 35:15-19
AJNR. American journal of neuroradiology. 2016 Jul 21; 37(12):2273-2279
Radiology. 2016 Jun; 279(3):693-707
Schizophrenia research. 2016 Apr; 172(1-3):94-100