Oded Gonen

Oded Gonen

Professor, Department of Radiology

Professor, Department of Neuroscience and Physiology

Keywords
Magnetic Resonance Spectroscopy and its applications to cancer, neurodegenerative diseases and psychiatric disorders, development of MR-spectroscopy tools to support to medical and biomedical research, imaging
Summary

In vivo localized MR spectroscopy (MRS) facilitates non-invasive investigations of the physiology and biochemistry (as opposed to the anatomic and morphologic information from MRI). The primarily focus of our research is the human brain, and to a lesser extent, other organs, e.g., the liver and pancreas, probed by 3-dimensional localized proton (but also phosphorus-31 and fluorine-19) MRS. An example of the differences and similarities between MRI and MRS is illustrated in the figure below. Our research projects propagate along three, parallel paths: First, technique development - the design of new localization methods, based on Fourier and Hadamard spatial encoding, to accommodate the higher magnetic fields that are now becoming available, and to tailor these methods to anatomies that traditionally have been inaccessible to existing methodologies, e.g., the spinal cord, optic nerve and cortex. Second, application of these methods to characterize normal and pathological metabolism by quantitatively comparing metabolic levels in the different anatomical structures. Our current clinical focuses are the processes of normal aging, multiple sclerosis and traumatic brain injury. Finally, the third direction is post- processing and visualization methodology and software development, to display the copious 3D information in a manner that will not hide the forest for the trees, because, after all, this is a department of radiology, so here, image is everything.

Phone

212-263-3532

Academic office

660 First Avenue

Fourth Floor

New York, NY 10016

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Professor, Department of Radiology

Professor, Department of Neuroscience and Physiology

Davitz, Matthew S; Wu, William E; Soher, Brian J; Babb, James S; Kirov, Ivan I; Huang, Jeffrey; Fatterpekar, Girish; Gonen, Oded

Magnetic resonance imaging. 2017 Jan; 35:15-19

Meyer, E J; Kirov, I I; Tal, A; Davitz, M S; Babb, J S; Lazar, M; Malaspina, D; Gonen, O

AJNR. American journal of neuroradiology. 2016 Jul 21; 37(12):2273-2279

Wu, Xin; Kirov, Ivan I; Gonen, Oded; Ge, Yulin; Grossman, Robert I; Lui, Yvonne W

Radiology. 2016 Jun; 279(3):693-707

Malaspina, Dolores; Kranz, Thorsten M; Heguy, Adriana; Harroch, Sheila; Mazgaj, Robert; Rothman, Karen; Berns, Adam; Hasan, Sumya; Antonius, Daniel; Goetz, Raymond; Lazar, Mariana; Chao, Moses V; Gonen, Oded

Schizophrenia research. 2016 Apr; 172(1-3):94-100

Mazgaj, Robert; Tal, Assaf; Goetz, Raymond; Lazar, Mariana; Rothman, Karen; Messinger, Julie Walsh; Malaspina, Dolores; Gonen, Oded

Brain imaging & behavior. 2016 Mar; 10(1):115-123

Chawla, S; Ge, Y; Lu, H; Marshall, O; Davitz, M S; Fatterpekar, G; Soher, B J; Gonen, O

AJNR. American journal of neuroradiology. 2015 Nov; 36(11):2055-2061

Grossman, Elan J; Kirov, Ivan I; Gonen, Oded; Novikov, Dmitry S; Davitz, Matthew S; Lui, Yvonne W; Grossman, Robert I; Inglese, Matilde; Fieremans, Els

Neuroimage. 2015 Sep; 118:334-343

Rossi Espagnet, M C; Bangiyev, L; Haber, M; Block, K T; Babb, J; Ruggiero, V; Boada, F; Gonen, O; Fatterpekar, G M

AJNR. American journal of neuroradiology. 2015 Aug; 36(8):1444-1449