Yu-Shin Ding, PhD

Professor, Department of Radiology

Professor, Department of Psychiatry

Yu-Shin Ding
Keywords
imaging, addiction, ADHD, PTSD, obesity, brown fat, diabetes, cardiovascular dysfunction
Summary

I have over 25 years of experience in the development and application/evaluation of novel PET ligands for translational research to study various disorders and biochemistry and mechanisms of drug action in living humans using PET, where my role is to bridge the fields of chemistry, biology and medicine. I have served as PI in various drug occupancy studies for phase I and phase II clinical trials for drug research and drug development in collaboration with pharmaceutical companies (Pfizer, GSK, etc.). I currently serve as the PI of several imaging grants studying drug mechanisms, obesity, tau and sleep. Our decades-long studies in humans using a norepinephrine transporter (NET) selective radiotracer ([11C]MRB) (>40 publications) have demonstrated a selective vulnerability of the LC-NE system to aging and stress and to various disorders; e.g., cocaine addiction, ADHD, PTSD, obesity, brown fat, diabetes, and cardiovascular dysfunction. My recent preliminary data reveals, for the first time, that the decline rate of NET, normally associated with aging due to loss in NET availability and cell death, is much faster in blacks starting in their mid-30s, particularly in black males. These results led to the novel molecular insight for the mechanistic characterization of the health disparity in aging and Alzheimer's disease, as the current biomarker classification system (i.e., the ATN model) may not fully account for the racial differences in AD risks. We propose that a faster decline of LC-NE function (decreased NET availability), resulting from chronic stress, occurs in blacks in midlife and at preclinical stages of AD and is responsible for the different disease expression among blacks.

Phone

212-263-6605

Academic office

660 First Avenue

Fourth Floor

New York, NY 10016

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PhD from State University of New York at Stony Brook

Brookhaven National Laboratory, Upton, NY, Positron Emission Tomography (PET) Medical Imaging

Kelleher, Andrew C; Richardson, Brandon; Kumar Banka, Vinay; Kazior, Alex; Tan, Cathy; Chan, Sabrina; Khastgir, Rumaish; Hu, Hao; Youss, Zakia; Mishkit, Orin; Ding, Yu-Shin

RSC medicinal chemistry. 2025 Feb 06;

Banka, Vinay Kumar; Sainas, Stefano; Martino, Elena; Wang, Jiacheng; Lolli, Marco Lucio; Ding, Yu-Shin

RSC medicinal chemistry. 2024 Jul 22; 15(9):3147-61

Banka, Vinay; Kelleher, Andrew; Sehlin, Dag; Hultqvist, Greta; Sigurdsson, Einar M; Syvänen, Stina; Ding, Yu-Shin

Frontiers in nuclear medicine (Lausanne, Switzerland). 2023 Sep; 3:

Griebsch, Nora-Isabell; Kern, Johanna; Hansen, Jonas; Rullmann, Michael; Luthardt, Julia; Helfmeyer, Stephanie; Dekorsy, Franziska J; Soeder, Marvin; Hankir, Mohammed K; Zientek, Franziska; Becker, Georg-Alexander; Patt, Marianne; Meyer, Philipp M; Dietrich, Arne; Blüher, Matthias; Ding, Yu-Shin; Hilbert, Anja; Sabri, Osama; Hesse, Swen

Brain sciences. 2022 Oct 26; 12(11):

Ding, Yu-Shin; Wang, Jiacheng; Kumar, Vinay; Ciaccio, James; Dakhel, Sami; Tan, Cathy; Kim, Jonathan; Lee, Sabrina; Katz-Lichtenstein, Hilla; Gironda, Zakia; Mishkit, Orin; Mroz, Jakub; Jackson, Raul; Yoon, Grace; Gamallo-Lana, Begona; Klores, Molly; Mar, Adam

International journal of innovative research in medical science. 2022 Jun; 7(6):254-271

Soeder, J Marvin; Luthardt, Julia; Rullmann, Michael; Becker, Georg A; Hankir, Mohammed K; Patt, Marianne; Meyer, Philipp M; Schütz, Tatjana; Ding, Yu-Shin; Hilbert, Anja; Dietrich, Arne; Sabri, Osama; Hesse, Swen

Obesity surgery. 2021 Nov; 31(11):4868-4876

Goldstein, David S; Isonaka, Risa; Holmes, Courtney; Ding, Yu-Shin; Sharabi, Yehonatan

Annals of clinical & translational neurology. 2020 Oct; 7(10):1908-1918

Ding, Yu-Shin; Malik, Noeen; Mendoza, Sebastian; Tuchman, Daniel; Del Pozo, Carmen Hurtado; Diez, Raquel Lopez; Schmidt, Ann-Marie

Journal of biosciences. 2019 Sep; 44(4):