Research interests are directed toward developing and applying the quantitative measures at high field MRI in various brain diseases including multiple sclerosis (MS), traumatic brain injury (TBI), brain tumors, and other neurodegenerative diseases. The implementation of these advanced MRI techniques in these diseases has greatly improved our understanding of the dynamics of disease evolution, clinicoradiological correlation, and efficacy of experimental treatments. These advanced techniques include:
1. Volumetric and histographical analysis: objective assessment of lesion load, tissue atrophy, and disease activity.
2. Diffusion tensor imaging (DTI) and fiber tractography (Fig 1): measuring the diffusion characteristics of tissue water can provide information about white matter integrity, connectivity, and pathological substrate of brain lesions.
3. Susceptibility weighted imaging (Fig 2): a 3D high resolution imaging (SWI) that provides high quality of MR venography and susceptibility sensitive technique especially at higher field-strength MR.
4. MR perfusion and functional MR imaging: mapping cerebral blood flow and volume in tissues to evaluate the critical components of blood supply and hemodynamic conditions in the brain. With event-associated fMRI and resting-state fMRI, brain activity related to a specific task or sensory process as well as functional network can be imaged.
It is believed that at higher field strengths of MR such as 7 Tesla, new areas of research are opening up in microscopic and molecular imaging, biomedical imaging, and functional brain imaging and these ultra-high-field systems will evolve into a new standard for clinical care and scientific discovery.
Professor, Department of Radiology
MD from Shandong University
Fellowship, Beijing Tiantan Hospital, Neuroimaging
Residency, Beijing Tiantan Hospital, Radiology
Journal of magnetic resonance imaging. 2017 Jul 21; ?-?
PLoS one. 2017 May 2; 12(5):e0176610-e0176610e0176610
Journal of cerebral blood flow & metabolism. 2016 Dec; 36(12):2087-2095
Characterization of cortical pathology and lesion patterns in patients with multiple sclerosis and neuromyelitis optica with high resolution 7T MRI. [Meeting Abstract]
Multiple sclerosis. 2016 Sep; 22:24-25
Longitudinal study of MS lesions using multi-parametric ultra-high field (7Tesla) MRI [Meeting Abstract]
Multiple sclerosis. 2016 Sep; 22:240-240
Neurology neuroimmunology & neuroinflammation. 2016 Aug; 3(4):e259-e259e259
AJNR. American journal of neuroradiology. 2016 Jul; 37(7):1223-1230
MAGMA (European Society for Magnetic Resonance in Medicine & Biology). 2016 Jun; 29(3):535-541