Recent Publications

  1. Abedini A, Plesner A, Cao P, Ridgway Z, Zhang J, Tu LH, Middleton CT, Chao B, Sartori DJ, Meng F, Wang H, Wong AG, Zanni MT, Verchere CB, Raleigh DP, Schmidt AM. Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics. Elife. 2016 May 23; 5. pii: e12977. doi: 10.7554/eLife.12977.
  2. Juranek JK, Daffu GK, Geddis MS, Li H, Rosario R, Kaplan BJ, Kelly L, Schmidt AM. Soluble RAGE Treatment Delays Progression of Amyotrophic Lateral Sclerosis in SOD1 Mice. Front Cell Neurosci. 2016 May 9; 10:117. doi: 10.3389/fncel.2016.00117.
  3. López-Díez R, Shekhtman A, Ramasamy R, Schmidt AM. Cellular mechanisms and consequences of glycation in atherosclerosis and obesity. Biochim Biophys Acta. 2016 May 8. pii: S0925-4439(16)30113-2. doi: 10.1016/j.bbadis.2016.05.005.
  4. Thiagarajan D, Ananthakrishnan R, Zhang J, O’Shea KM, Quadri N, Li Q, Sas K, Jing X, Rosario R, Pennathur S, Schmidt AM, Ramasamy R. Aldose Reductase Acts as a Selective Derepressor of PPARg and the Retinoic Acid Receptor, Cell Reports (2016),
  5. Manigrasso MB, Pan J, Rai V, Zhang J, Reverdatto S, Quadri N, DeVita RJ, Ramasamy R, Shekhtman A, and Schmidt AM.  Small molecule inhibition of ligand-stimulated RAGE-DIAPH1 signal transduction. 2016 Sci Rep 6:22450.
  6. Juranek JK, Daffu GK, Wojtkiewicz J, Lacomis D, Kofler J, Schmidt AM. Receptor for Advanced Glycation End Products and its Inflammatory Ligands are Upregulated in Amyotrophic Lateral Sclerosis. Front Cell Neurosci. 2015 Dec 22;9:485. doi: 10.3389/fncel.2015.00485.
  7. Ramasamy R, Shekhtman A, Schmidt AM. The multiple faces of RAGE - opportunities for therapeutic intervention in aging and chronic disease. Expert Opin Ther Targets. 2015 Nov 11:1-16.
  8. Daffu G, Shen X, Senatus L, Thiagarajan D, Abedini A, Hurtado Del Pozo C, Rosario R, Song F, Friedman RA, Ramasamy R, Schmidt AM. RAGE Suppresses ABCG1-Mediated Macrophage Cholesterol Efflux in Diabetes. Diabetes.  Epub 2015 Aug 7. pii: db150575.
  9. Zirpoli H, Abdillahi M, Quadri N, Ananthakrishnan R, Wang L, Rosario R, Zhu Z, Deckelbaum RJ, Ramasamy R. Acute administration of n-3 rich triglyceride emulsions provides cardioprotection in murine models after ischemia-reperfusion. PLoS One, 10(1), 2015, e0116274.
  10. Gao, M, Monian P, Quadri  N, Ramasamy R, and Jiang X.  Glutaminolysis and Transferrin Regulate Ferroptosis.  Mol Cell 59(2), 2015, 298-308.
  11. Schmidt AM. Soluble RAGEs - Prospects for treating & tracking metabolic and inflammatory disease. Vascul Pharmacol. 2015. doi: 10.1016/j.vph.2015.06.01.
  12. Schmidt AM. The growing problem of obesity: mechanisms, consequences, and therapeutic approaches. Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):e19-23. doi: 10.1161/ATVBAHA.115.305753.
  13. Litwinoff EM, Hurtado Del Pozo C, Ramasamy R, Schmidt AM. Emerging targets for therapeutic development in diabetes and its complications: The RAGE signaling pathway. Clin Pharmacol Ther. 2015 May 13. doi: 10.1002/cpt.148.
  14. Grossin N, Auger F, Niquet-Leridon C, Durieux N, Montaigne D, Schmidt AM, Susen S, Jacolot P, Beuscart JB, Tessier FJ, Boulanger E. Dietary CML-enriched protein induces functional arterial aging in a RAGE-dependent manner in mice. Mol Nutr Food Res. 2015 May; 59(5):927-38. doi: 10.1002/mnfr.201400643.
  15. Goury A, Meghraoui-Kheddar A, Belmokhtar K, Vuiblet V, Ortillon J, Jaisson S, Devy J, Le Naour R, Tabary T, Cohen JH, Schmidt AM, Rieu P, Touré F. Deletion of receptor for advanced glycation end products exacerbates lymphoproliferative syndrome and lupus nephritis in B6-MRL Fas lpr/j mice. J Immunol. 2015 Apr 15;194(8):3612-22. doi: 10.4049/jimmunol.1402342.
  16. Ramasamy R, Schmidt AM. 'Etiology of diabetes mellitus' IN: Diabetes Mellitus and Oral Health: An Interprofessional Approach [S.l.]: Wiley, 2014 p.1-26. (Book Chapter)
  17. Ramasamy R, Yan SF, Schmidt AM. ‘Vascular Biology of Atherosclerosis in Patients with Diabetes: Hyperglycemia, Insulin Resistance, and Hyperinsulinemia’ IN: Diabetes in Cardiovascular Disease: A Companion to Braunwald's Heart Disease. Elsevier Health Sciences, 2014 p. 99-110. (Book Chapter)
  18. Parikh M, Chung M, Sheth S, McMacken M, Zahra T, Saunders JK, Ude-Welcome A, Dunn V, Ogedegbe G, Schmidt AM, Pachter HL.  Randomized Pilot Trial of Bariatric Surgery Versus Intensive Medical Weight Management on Diabetes Remission in Type 2 Diabetic Patients Who Do NOT Meet NIH Criteria for Surgery and the Role of Soluble RAGE as a Novel Biomarker of Success.  Ann Surg. 2014 Oct; 260(4):617-24. doi: 10.1097/SLA.0000000000000919.
  19. Song F, Hurtado del Pozo C, Rosario R, Zou YS, Ananthakrishnan R, Xu X, Patel PR, Benoit VM, Yan SF, Li H, Friedman RA, Kim JK, Ramasamy R, Ferrante AW Jr, Schmidt AM.  RAGE Regulates the Metabolic and Inflammatory Response to High Fat Feeding in Mice.   Diabetes. 2014 Jun;63(6):1948-65. doi:10.2337/db13-1636. Epub 2014 Feb 11.
  20. Vedantham S, Thiagarajan D, Ananthakrishnan R, Wang L, Rosario R, Zou YS, Goldberg I, Yan SF, Schmidt AM, Ramasamy R.  Aldose Reductase drives hyperacetylation of Egr-1 in hyperglycemia and consequent upregulation of proinflammatory and prothrombotic signals. Diabetes. 2014 Feb;63(2):761-74. doi: 10.2337/db13-0032. Epub 2013 Nov 1.
  21. Juranek JK, Kothary P, Mehra A, Hays A, Brannagan TH 3rd, Schmidt AM.  Increased expression of the receptor for advanced glycation end-products in human peripheral neuropathies.  Brain and Behavior. 2013 Nov;3(6):701-9. doi: 10.1002/brb3.176. Epub 2013 Oct 8.
  22. Daffu G, Del Pozo CH, O'Shea KM, Ananthakrishnan R, Ramasamy R, Schmidt AM.  Radical Roles for RAGE in the Pathogenesis of Oxidative Stress in Cardiovascular Diseases and Beyond.  Int J Mol Sci. 2013 Oct 1;14(10):19891-910. doi: 10.3390/ijms141019891.
  23. Juranek JK, Geddis MS, Rosario R, Schmidt AM.  Impaired slow axonal transport in diabetic peripheral nerve is independent of RAGE.  Eur J Neurosci.  2013 Oct;38(8):3159-68. doi: 10.1111/ejn.12333. Epub 2013 Aug 14.
  24. Manigrasso MB, Juranek J, Ramasamy R, Schmidt AM.  Unlocking the biology of RAGE in diabetic microvascular complications.  Trends Endocrinol Metab. 2014 Jan;25(1):15-22. doi:pii: S1043-2760(13)00134-3. 10.1016/j.tem.2013.08.002. Epub 2013 Sep 3.
  25. Kong L, Shen X, Lin L, Leitges M, Rosario R, Zou YS, Yan SF.  PKCβ promotes vascular inflammation and acceleration of atherosclerosis in diabetic ApoE null mice.  Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1779-87. doi: 10.1161/ATVBAHA.112.301113. Epub 2013 Jun 13.
  26. Juranek JK, Geddis MS, Kothary P, Hays A, Schmidt AM, Brannagan TH 3rd.  Reduced expression of Munc13-1 in human and porcine diabetic peripheral nerve.  Acta Histochem. 2014 Jan;116(1):106-11. doi:pii: S0065-1281(13)00109-8. 10.1016/j.acthis.2013.05.010. Epub 2013 Jul 5.
  27. Reverdatto S, Rai V, Xue J, Burz DS, Schmidt AM, Shekhtman A.  Combinatorial library of improved peptide aptamers, CLIPs to inhibit RAGE signal transduction in mammalian cells.  PLoS One. 2013 Jun 13;8(6):e65180. doi: 10.1371/journal.pone.0065180.
  28. Abedini A, Schmidt AM.  Mechanisms of islet amyloidosis toxicity in type 2 diabetes.  FEBS Lett. 2013 Apr 17;587(8):1119-27. doi:10.1016/j.febslet.2013.01.017. Epub 2013 Jan 18. Review.
  29. Juranek JK, Geddis MS, Song F, Zhang J, Garcia J, Rosario R, Yan SF, Brannagan TH, Schmidt AM.  RAGE Deficiency Improves Postinjury Sciatic Nerve Regeneration in Type 1 Diabetic Mice.  Diabetes. 2013 Mar; 62(3):931-43. doi: 10.2337/db12-0632.
  30. Ananthakrishnan R, Li Q, O'Shea KM, Quadri N, Wang L, Abuchowski A, Schmidt AM, Ramasamy R.  Carbon monoxide form of PEGylated hemoglobin protects myocardium against ischemia/reperfusion injury in diabetic and normal mice.  Artif Cells Nanomed. 2013 Dec;41(6):428-36. doi: 10.3109/21691401.2012.762370. Epub 2013 Jan 23
  31. Rai V, Touré F, Chitayat S, Pei R, Song F, Li Q, Zhang J, Rosario R, Ramasamy R, Chazin WJ, Schmidt AM.  Lysophosphatidic acid targets vascular and oncogenic pathways via RAGE signaling.  J Exp Med. 2012 Dec 17;209(13):2339-50. doi: 10.1084/jem.20120873.
  32. Son NH, Ananthakrishnan R, Yu S, Khan RS, Jiang H, Ji R, Akashi H, Li Q, O'Shea K, Homma S, Goldberg IJ, Ramasamy R.  Cardiomyocyte aldose reductase causes heart failure and impairs recovery from ischemia.  PLoS One. 2012;7(9):e46549.   doi:10.1371/journal.pone.0046549.
  33. Song F, Schmidt AM.  Glycation & Insulin Resistance: Novel Mechanisms and Unique Targets? ATVB.  2012 Aug;32(8):1760-5.
  34. Ramasamy R, Yan SF, Schmidt AM.  The Diverse Ligand Repertoire of the Receptor for Advanced Glycation Endproducts & Pathways to the Complications of Diabetes.  Vasc Pharm.  2012 Nov-Dec;57(5-6):160-7. doi: 10.1016/j.vph.2012.06.004.
  35. Abdillahi M, Ananthakrishnan R, Vedantham S, Shang L, Zhu Z, Rosario R, Zirpoli H, Bohren KM, Gabbay KH, Ramasamy R.  Aldose reductase modulates cardiac glycogen synthase kinase-3ßphosphorylation during ischemia-reperfusion.  Am J Physiol Heart Circ Physiol. 2012 2012 Aug 1; 303(3):H297-308. doi: 10.1152/ajpheart.00999.2011.
  36. Ramasamy R, Schmidt AM.  Receptor for Advanced Glycation End Products (RAGE) and Implications for the Pathophysiology of Heart Failure.  Curr Heart Fail Rep. 2012 Jun;9(2):107-16.
  37. Vedantham S, Ananthakrishnan R, Schmidt AM, Ramasamy R.  Aldose Reductase, Oxidative Stress and Diabetic Cardiovascular Complications.  Cardiovasc Hematol Agents Med Chem. 2012 Sep;10(3):234-40.
  38. Touré F, Fritz G, Li Q, Rai V, Daffu G, Zou YS, Rosario R, Ramasamy R, Alberts AS, Yan SF, Schmidt AM.  Formin mDia1 Mediates Vascular Remodeling via Integration of Oxidative and Signal Transduction Pathways.  Circ Res. 2012 May 11;110(10):1279-93.
  39. Tekabe Y, Luma J, Li Q, Schmidt AM, Ramasamy R, Johnson L.   Imaging RAGE expression in a mouse model of myocardial ischemia and reperfusion injury. JACC Cardiovascular Imaging, 2012 Jan;5(1):59-67.
  40. Ramasamy R, Yan SF, Schmidt AM.  Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications.  Ann N Y Acad Sci. 2011 Dec; 1243(1):88-102. doi: 10.1111/j.1749-6632.2011.06320.x.
  41. Cao P, Tu LH, Abedini A, Levsh O, Akter R, Patsalo V, Schmidt AM, Raleigh DP.  Sensitivity of Amyloid Formation by Human Islet Amyloid Polypeptide to Mutations at Residue 20.  J Mol Biol. 2012 Aug 10;421(2-3):282-95. doi: 10.1016/j.jmb.2011.12.032.
  42. Rai V, Maldonado AY, Burz DS, Reverdatto S, Schmidt AM, Shekhtman A.  Signal transduction in RAGE: solution structure of C-terminal RAGE (ctRAGE) and its binding to mDia1.  J Biol Chem. 2012 Feb 10;287(7):5133-44. doi: 10.1074/jbc.M111.277731.
  43. Zeng S, Zhang QY, Huang J, Vedantham S, Rosario R, Ananthakrishnan R, Yan SF, Ramasamy R, DeMatteo RP, Emond JC, Friedman RA, and Schmidt AM.  Opposing roles of RAGE and Myd88 signaling in extensive liver resection.  FASEB J. 2012 Feb;26(2):882-93. doi: 10.1096/fj.11-192997. Epub 2011 Nov 10.
  44. Devisser A, Yang C, Herring A, Martinez JA, Rosales-Hernandez A, Poliakov I, Ayer A, Garven A, Zaver S, Rincon N, Xu K, Tuor UI, Schmidt AM and Toth C. Differential impact of diabetes and hypertension in the brain: Adverse effects in grey matter. Neurobiol Dis. 2011 Nov;44(2):161-73.
  45. Ananthakrishnan R, Li Q, Gomes T, Schmidt AM and Ramasamy R. Aldose reductase pathway contributes to vulnerability of aging myocardium to ischemic injury. Exp Gerontol. 2011 Sep;46(9):762-7.
  46. Vedantham S, Noh H, Ananthakrishnan R, Son N, Hallam K, Hu Y, Yu S, Shen X, Rosario R, Lu Y, Ravindranath T, Drosatos K, Huggins LA, Schmidt AM, Goldberg IJ and Ramasamy R. Human aldose reductase expression accelerates atherosclerosis in diabetic apolipoprotein E-/- mice. Arterioscler Thromb Vasc Biol. 2011 Aug;31(8):1805-13.
  47. Hofmann Bowman MA, Fedson S and Schmidt AM. Advanced glycation end products in diabetic cardiomyopathy: An alternative hypothesis. J Heart Lung Transplant. 2011 Nov;30(11):1303; discussion 1303-4. doi: 10.1016/j.healun.2011.06.004.
  48. Tekabe Y, Shen X, Luma J, Weisenberger D, Yan SF, Haubner R, Schmidt AM, Johnson L.  Imaging the effect of receptor for advanced glycation endproducts on angiogenic response to hindlimb ischemia in diabetes.EJNMMI Res. 2011 Jun 7;1(1):3.
  49. Yang C, DeVisser A, Martinez JA, Poliakov I, Rosales-Hernandez A, Ayer A, Garven A, Zaver S, Rincon N, Xu K, Tuor UI, Schmidt AM and Toth C. Differential impact of diabetes and hypertension in the brain: adverse effects in white matter. Neurobiol Dis. 2011 Jun;42(3):446-58.
  50. Kalea AZ, Schmidt AM and Hudson BI. Alternative splicing of RAGE: roles in biology and disease. Front Biosci. 2011 Jun;17:2756-70.
  51. Onat D, Brillon D, Colombo PC and Schmidt AM. Human vascular endothelial cells: a model system for studying vascular inflammation in diabetes and atherosclerosis. Curr Diab Rep. 2011 Jun;11(3):193-202.
  52. Hofmann Bowman MA, Schmidt AM.  S100/calgranulins EN-RAGEing the blood vessels: implications for inflammatory responses and atherosclerosis.  Am J Cardiovasc Dis. 2011;1(1):92-100.
  53. Xue J, Rai V, Singer D, Chabierski S, Xie J, Reverdatto S, Burz DS, Schmidt AM, Hoffmann R and Shekhtman A. Advanced glycation end product recognition by the receptor for AGEs. Structure.  2011 May 11;19(5):722-32.
  54. Hudson BI, Moon YP, Kalea AZ, Khatri M, Marquez C, Schmidt AM, Paik MC, Yoshita M, Sacco RL, DeCarli C, Wright CB and Elkind MS. Association of serum soluble receptor for advanced glycation end-products with subclinical cerebrovascular disease: the Northern Manhattan Study (NOMAS). Atherosclerosis.  2011 May;216(1):192-8.