Welcome to the Nolan Lab

Lab Overview

Our studies focus on predictors of lung function loss in never smoking firefighters from the World Trade Center exposed Fire Department of New York cohort. This group has pre-9/11/01 clinical/spirometric data and continues to have serial post-9/11 assessments. In preliminary data, we demonstrate that elevated serum levels of one such LDL byproduct soon after intense WTC dust exposure is a risk factor for developing abnormal forced expiratory volume in one second (FEV1) years later.  This development of lung injury is what we call World Trade Center Lung Injury (WTC-LI).

Our group has demonstrated that mediators of Metabolic Syndrome, inflammation and vascular injury in serum sampled within 6 months of 9/11 are predictive of eventual abnormal lung function. Lipids and their metabolites have been linked to pulmonary inflammation and subsequent airflow obstruction.

Development of ventilatory dysfunction following particulate exposure is a major health concern worldwide. The prevalence of metabolic syndrome is high in industrialized nations and is rapidly increasing in developing nations with high ambient particulates. The interaction of these two disorders is a topic of considerable importance. Our work will define the additive inflammatory effects of lipid mediators on a background of PM exposure.

View an interview with Dr. Nolan: Study Shows Biomarkers May Hold Clues To WTC Firefighters' Lung Health

Metabolomics

Metabolite Expression Plot

Lean more about the first-ever global metabolomic modeling on the WTC-particulate exposed FDNY Firefighters.

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Upcoming Conferences

We will be presenting a number of research projects in the coming months. Find out where.

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Lab Members

Lab Members

Get to know the Nolan Lab.

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