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Hubbard Lab Publications
Researchers in the Hubbard Lab use X-ray crystallography to conduct structural studies of protein tyrosine kinases. Learn more about our work by reading the latest publications.
Recent Publications
Biochemical characterization of the Drosophila insulin receptor kinase and longevity-associated mutants
FASEB journal. 2024 Jan ; 38:e23355
New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation
Cell chemical biology. 2023 Jun 15; 30:618-631.e12
Structural basis of Janus kinase trans-activation
Cell reports. 2023 Mar 28; 42:112201
Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain
Pharmaceuticals. 2023 Jan 01; 16:?-?
Unlocking the secrets to Janus kinase activation
Science. 2022 Apr 08; 376:139-140
Increased resistance of SARS-CoV-2 Omicron variant to neutralization by vaccine-elicited and therapeutic antibodies
EBioMedicine. 2022 Apr ; 78:103944
Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations
Science. 2020 Feb 07; 367:643-652
KRAS4A directly regulates hexokinase 1
Nature. 2019 Dec ; 576:482-486