Hubbard Lab Publications

Researchers in the Hubbard Lab use X-ray crystallography to conduct structural studies of protein tyrosine kinases. Learn more about our work by reading the latest publications.

Recent Publications

Biochemical characterization of the Drosophila insulin receptor kinase and longevity-associated mutants

Krishnan, Harini; Ahmed, Sultan; Hubbard, Stevan R; Miller, W Todd

FASEB journal. 2024 Jan ; 38:e23355

New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation

Arwood, Matthew L; Liu, Yao; Harkins, Shannon K; Weinstock, David M; Yang, Lei; Stevenson, Kristen E; Plana, Olivia D; Dong, Jingyun; Cirka, Haley; Jones, Kristen L; Virtanen, Anniina T; Gupta, Dikshat G; Ceas, Amanda; Lawney, Brian; Yoda, Akinori; Leahy, Catharine; Hao, Mingfeng; He, Zhixiang; Choi, Hwan Geun; Wang, Yaning; Silvennoinen, Olli; Hubbard, Stevan R; Zhang, Tinghu; Gray, Nathanael S; Li, Loretta S

Cell chemical biology. 2023 Jun 15; 30:618-631.e12

Structural basis of Janus kinase trans-activation

Caveney, Nathanael A; Saxton, Robert A; Waghray, Deepa; Glassman, Caleb R; Tsutsumi, Naotaka; Hubbard, Stevan R; Garcia, K Christopher

Cell reports. 2023 Mar 28; 42:112201

Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain

Virtanen, Anniina T.; Haikarainen, Teemu; Sampathkumar, Parthasarathy; Palmroth, Maaria; Liukkonen, Sanna; Liu, Jianping; Nekhotiaeva, Natalia; Hubbard, Stevan R.; Silvennoinen, Olli

Pharmaceuticals. 2023 Jan 01; 16:?-?

Unlocking the secrets to Janus kinase activation

Levine, Ross L; Hubbard, Stevan R

Science. 2022 Apr 08; 376:139-140

Increased resistance of SARS-CoV-2 Omicron variant to neutralization by vaccine-elicited and therapeutic antibodies

Tada, Takuya; Zhou, Hao; Dcosta, Belinda M; Samanovic, Marie I; Chivukula, Vidya; Herati, Ramin S; Hubbard, Stevan R; Mulligan, Mark J; Landau, Nathaniel R

EBioMedicine. 2022 Apr ; 78:103944

Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Wilmes, Stephan; Hafer, Maximillian; Vuorio, Joni; Tucker, Julie A; Winkelmann, Hauke; Löchte, Sara; Stanly, Tess A; Pulgar Prieto, Katiuska D; Poojari, Chetan; Sharma, Vivek; Richter, Christian P; Kurre, Rainer; Hubbard, Stevan R; Garcia, K Christopher; Moraga, Ignacio; Vattulainen, Ilpo; Hitchcock, Ian S; Piehler, Jacob

Science. 2020 Feb 07; 367:643-652

KRAS4A directly regulates hexokinase 1

Amendola, Caroline R; Mahaffey, James P; Parker, Seth J; Ahearn, Ian M; Chen, Wei-Ching; Zhou, Mo; Court, Helen; Shi, Jie; Mendoza, Sebastian L; Morten, Michael J; Rothenberg, Eli; Gottlieb, Eyal; Wadghiri, Youssef Z; Possemato, Richard; Hubbard, Stevan R; Balmain, Allan; Kimmelman, Alec C; Philips, Mark R

Nature. 2019 Dec ; 576:482-486

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Hubbard Lab Publications | NYU Langone Health