Hubbard Lab Publications

Researchers in the Hubbard Lab use X-ray crystallography to conduct structural studies of protein tyrosine kinases. Learn more about our work by reading the latest publications.

Recent Publications

Catalytic activities of wild-type C. elegans DAF-2 kinase and dauer-associated mutants

Krishnan, Harini; Ahmed, Sultan; Hubbard, Stevan R; Miller, W Todd

FEBS journal. 2024 Dec ; 291:5435-5454

Biochemical characterization of the Drosophila insulin receptor kinase and longevity-associated mutants

Krishnan, Harini; Ahmed, Sultan; Hubbard, Stevan R; Miller, W Todd

FASEB journal. 2024 Jan ; 38:e23355

New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation

Arwood, Matthew L; Liu, Yao; Harkins, Shannon K; Weinstock, David M; Yang, Lei; Stevenson, Kristen E; Plana, Olivia D; Dong, Jingyun; Cirka, Haley; Jones, Kristen L; Virtanen, Anniina T; Gupta, Dikshat G; Ceas, Amanda; Lawney, Brian; Yoda, Akinori; Leahy, Catharine; Hao, Mingfeng; He, Zhixiang; Choi, Hwan Geun; Wang, Yaning; Silvennoinen, Olli; Hubbard, Stevan R; Zhang, Tinghu; Gray, Nathanael S; Li, Loretta S

Cell chemical biology. 2023 Jun 15; 30:618-631.e12

Structural basis of Janus kinase trans-activation

Caveney, Nathanael A; Saxton, Robert A; Waghray, Deepa; Glassman, Caleb R; Tsutsumi, Naotaka; Hubbard, Stevan R; Garcia, K Christopher

Cell reports. 2023 Mar 28; 42:112201

Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain

Virtanen, Anniina T.; Haikarainen, Teemu; Sampathkumar, Parthasarathy; Palmroth, Maaria; Liukkonen, Sanna; Liu, Jianping; Nekhotiaeva, Natalia; Hubbard, Stevan R.; Silvennoinen, Olli

Pharmaceuticals. 2023 Jan 01; 16:?-?

Unlocking the secrets to Janus kinase activation

Levine, Ross L; Hubbard, Stevan R

Science. 2022 Apr 08; 376:139-140

Increased resistance of SARS-CoV-2 Omicron variant to neutralization by vaccine-elicited and therapeutic antibodies

Tada, Takuya; Zhou, Hao; Dcosta, Belinda M; Samanovic, Marie I; Chivukula, Vidya; Herati, Ramin S; Hubbard, Stevan R; Mulligan, Mark J; Landau, Nathaniel R

EBioMedicine. 2022 Apr ; 78:103944

Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Wilmes, Stephan; Hafer, Maximillian; Vuorio, Joni; Tucker, Julie A; Winkelmann, Hauke; Löchte, Sara; Stanly, Tess A; Pulgar Prieto, Katiuska D; Poojari, Chetan; Sharma, Vivek; Richter, Christian P; Kurre, Rainer; Hubbard, Stevan R; Garcia, K Christopher; Moraga, Ignacio; Vattulainen, Ilpo; Hitchcock, Ian S; Piehler, Jacob

Science. 2020 Feb 07; 367:643-652

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Hubbard Lab Publications | NYU Langone Health