In NYU Langone’s Kang Lab, we are interested in understanding the pathogenesis of Parkinson’s disease (PD) and mechanism of its therapy. The degeneration of dopaminergic neurons in the midbrain instigates plasticity in the basal ganglia circuits, some of which are beneficial to the patients by compensating for the deficit while others are maladaptive changes that lead to abnormal involuntary movements in response to pharmacological dopaminergic replacement. In addition, we are interested in the dysfunction of non-dopaminergic systems that produces gait abnormalities including freezing as well as non-motor complications. We utilize mouse models of PD for these studies.
We are also interested in discovering the mechanism of the degenerative processes through biomarkers that can be measured in patients with Parkinson’s disease and related synucleinopathies such as multiple system atrophy.
Un Jung Kang, MD
NYU Langone Health Science Building, 13th Floor
435 East 30th Street
New York, NY 10016
Please contact Dr. Kang, director of translational research at the Marlene and Paolo Fresco Institute for Parkinson’s and Movement Disorders, at 212-263-4838. The Fresco Institute is located at 222 East 41st Street on the 13th floor.