The Ramkhelawon Lab conducts pioneering vascular research, exploring the complex interplay of factors that influence the health and function of arteries and veins. Our work extends beyond fundamental vascular biology to investigate how age, environment, and behavior significantly contribute to vascular disease. We are dedicated to translating our discoveries into practical clinical applications that improve patient outcomes. We are also committed to fostering the next generation of vascular scientists through robust mentoring and educational programs.

Our Core Research Areas include:

1. Vascular Biology: We delve into the molecular and cellular mechanisms governing vascular health, including endothelial function, smooth muscle cell dynamics, macrophage signaling and signaling pathways.
2. Vascular Inflammation and Remodeling: We study the role of inflammation and remodeling in vascular diseases, considering how environmental exposures, multiorgan corsstalks and behavioral patterns contribute to these processes. We also study how platelets can reprogram the immune system and regulate vascular functions.
3. Sex differences in vascular disease: The lab is also researching the differences between male and female vascular systems, and how those differences, combined with environmental, behavioral, and aneurysm related factors, impact disease progression.
4. Age-Related Vascular Changes: We examine how aging affects vascular structure and function, including arterial stiffening, endothelial dysfunction, and increased susceptibility to thrombosis, and aortic aneurysm development.
5. Behavioral Influences: We study the impact of lifestyle factors such as diet, exercise, smoking, and stress on vascular function, aiming to understand how these behaviors contribute to cardiovascular risk and aneurysm development.
6. Vascular diseases: we study mechanism of that drive life-threatening diseases with limited treatment options for patients such as aortic aneurysms (abdominal, thoracic and Marfan’s syndrome), Peripheral Artery Diseases (PAD), DVT.
7. Translational Research: We bridge the gap between basic science and clinical application, developing innovative diagnostic and therapeutic strategies informed by our understanding of age, environmental, behavioral, and aneurysm-related influences.
8. Mentoring and Education: We are dedicated to providing comprehensive mentoring and educational opportunities for students, postdoctoral fellows, and early-career researchers. We foster a collaborative learning environment that promotes scientific excellence and professional development.

We use a multidisciplinary approach, integrating:

• Cellular and molecular biology techniques
• In vivo and in vitro models, including models of aging, environmental exposure, and aortic aneurysm development.
• Advanced imaging modalities to assess vascular function and aneurysm progression.
• Genomic and proteomic analyses, including epigenetics, to understand how environment, behavior, and genetic predispositions alter gene expression in vascular disease and aneurysms.
• Dedicated training programs, workshops, and seminars to enhance research skills and knowledge.

Furthermore, we are committed to cultivating a vibrant research community through dedicated mentoring and educational initiatives as well as fostering a collaborative and innovative research environment, dedicated to making significant contributions to the field of vascular medicine.

We are excited to grow our team and welcome passionate individuals to contribute to our mission. Please do not hesitate to contact us if you are interested in joining our research efforts.

Read more about our research here- add PUBMED link- https://pubmed.ncbi.nlm.nih.gov/?term=ramkhelawon+b&sort=date

Contact Us

Bhama Ramkhelawon, PhD

Associate Professor of Surgery and Cell Biology
Director Vascular Research Program

New York University Langone Health
Science Building, room 416 (office), 423 (lab)
435 East 30th street, New York, NY  10016
Phone (office): (212) 263-2281