Sigurdsson Lab Publications

Investigators in the Sigurdsson Lab publish the results of their research in leading publications. Read the latest papers to learn more about our work.

Recent Publications

Clearing truncated tau protein restores neuronal function and prevents microglia activation in tauopathy mice

Martín-Ávila, Alejandro; Modak, Swananda R; Rajamohamedsait, Hameetha B; Dodge, Andie; Shamir, Dov B; Krishnaswamy, Senthilkumar; Sandusky-Beltran, Leslie A; Walker, Marilyn; Lin, Yan; Congdon, Erin E; Sigurdsson, Einar M

Cell reports. 2025 Sep 16; 44:116291

Neuronal hypofunction and network dysfunction in a mouse model at an early stage of tauopathy

Ji, Changyi; Yang, Xiaofeng; Eleish, Mohamed; Jiang, Yixiang; Tetlow, Amber M; Song, Soomin C; Martín-Ávila, Alejandro; Wu, Qian; Zhou, Yanmei; Gan, Wenbiao; Lin, Yan; Sigurdsson, Einar M

Alzheimer's & dementia. 2024 Nov ; 20:7954-7970

Anti-tau single domain antibodies clear pathological tau and attenuate its toxicity and related functional defects

Nair, Sudershana; Jiang, Yixiang; Marchal, Isabella S; Chernobelsky, Elizabeth; Huang, Huai-Wei; Suh, Sarah; Pan, Ruimin; Kong, Xiang-Peng; Ryoo, Hyung Don; Sigurdsson, Einar M

Cell death & disease. 2024 Jul 30; 15:543

Single-domain antibody-based protein degrader for synucleinopathies

Jiang, Yixiang; Lin, Yan; Tetlow, Amber M; Pan, Ruimin; Ji, Changyi; Kong, Xiang-Peng; Congdon, Erin E; Sigurdsson, Einar M

Molecular neurodegeneration. 2024 May 31; 19:44

Tau-targeting therapies for Alzheimer disease: current status and future directions

Congdon, Erin E; Ji, Changyi; Tetlow, Amber M; Jiang, Yixiang; Sigurdsson, Einar M

Nature reviews. Neurology. 2023 Dec ; 19:715-736

Single-domain antibody-based noninvasive in vivo imaging of α-synuclein or tau pathology

Jiang, Yixiang; Lin, Yan; Krishnaswamy, Senthilkumar; Pan, Ruimin; Wu, Qian; Sandusky-Beltran, Leslie A; Liu, Mengyu; Kuo, Min-Hao; Kong, Xiang-Peng; Congdon, Erin E; Sigurdsson, Einar M

Science advances. 2023 May 10; 9:eadf3775

Single domain antibodies targeting pathological tau protein: Influence of four IgG subclasses on efficacy and toxicity

Congdon, Erin E; Pan, Ruimin; Jiang, Yixiang; Sandusky-Beltran, Leslie A; Dodge, Andie; Lin, Yan; Liu, Mengyu; Kuo, Min-Hao; Kong, Xiang-Peng; Sigurdsson, Einar M

EBioMedicine. 2022 Sep 10; 84:104249

Increased neuronal activity in motor cortex reveals prominent calcium dyshomeostasis in tauopathy mice

Wu, Qian; Bai, Yang; Li, Wei; Congdon, Erin E; Liu, Wenke; Lin, Yan; Ji, Changyi; Gan, Wen-Biao; Sigurdsson, Einar M

Neurobiology of disease. 2021 Jan ; 147:105165

Sigurdsson Lab Publications | NYU Langone Health