B-cell Immunobiology Lab | NYU Langone Health

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B-cell Immunobiology Lab

We aim to understand how antibodies coordinate the functions of the overall immune system.

Led by Gregg Silverman, MD, NYU Langone’s B-cell Immunobiology Lab is part of the Department of Medicine and its Division of Rheumatology. Our research group has focused on the body’s capacity to produce antibodies in health and in disease, and how these antibodies coordinate the functions of the overall immune system. We have been especially interested in better understanding the disease pathways in rheumatoid arthritis and in systemic lupus erythematosus. Our recent studies have led us to also investigate fundamental pathways of inflammation relevant to a broad range of diseases.

The lab currently utilizes a broad range of technologies for our research. For the development of well-characterized monoclonal antibodies, we apply protein engineering, phage-display technology, and prokaryotic expression systems. In addition, we have recently begun the production of recombinant IgG antibodies using bioreactor systems.

To characterize in vivo antibody repertoire expression, we have developed autoantigen microarrays using a robotic printer and more recently with multiplex bead-based assays. For identifying the functional properties of antibody-based agents we have also used in vitro culture systems, to assess responses in cell lines and primary cells. To investigate relevance to disease states, we are also exploring in vivo model inflammation systems using purified agonists for Toll-like receptors and other receptor molecules within the innate immune system, as well as murine models of inflammatory arthritis, lupus, and other conditions. As our ultimate goal is to develop better therapeutic agents, we study clinical samples from patients to understand the relevance of our investigations to human immune responses.

Since joining NYU Langone in 2011, we have initiated studies of the effects of the gut microbiome in mice and humans on B-cell responses, and we are also investigating B-cell responses during infections to Staphylococcus aureus.

Contact Us

Gregg Silverman, MD
Principal Investigator
The Mamdouha S. Bobst Professor of Internal Medicine, Department of Medicine
Professor, Department of Pathology
NYU Grossman School of Medicine
Science Building
435 East 30th Street, Room 517
New York, NY 10016
Office: Phone 212-263-9440
Email: gregg.silverman@nyulangone.org

Jessica Rosario
Administrative Assistant
Email: jessica.rosario@nyulangone.org