Sickle Cell Disease in Children | NYU Langone Health
Specialists at Hassenfeld Children’s Hospital at NYU Langone use blood tests to confirm a diagnosis of sickle cell disease.
Significance and Outcome of Magnetic Resonance Enterography Revealing Sacroiliitis in Crohn s Disease
This study aims to further define and characterize imaging findings of possible sacroiliitis in Crohn’s Disease patients by recalling subjects who had findings of possible sacroiliitis on prior MRE and assess the natural history and outcome of these cases by using standard magnetic resonance imaging (MRI) and x-ray of the sacroiliac joints. Participants will also undergo a detailed evaluation by a rheumatologist.
Silberstein Alzheimer’s Institute | NYU Langone Health
NYU Langone’s Silberstein Alzheimer’s Institute conducts research into the origins of memory disorders.
Simulation Order for Patients Undergoing Robotic-based SBRT: Identifying Predictors of Lengthier Insurance Authorization
Atherosclerotic cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide. Obesity increases risk for coronary heart disease and stroke. Prevention or regression of atherosclerosis would be informed by better understanding of the mechanisms that underlie development of atherosclerosis. Addressing this, we have identified a potential link between obese fat and atherosclerosis via exosomes. These exosomes, are capable of communicating between cells at a distance. The experiments proposed will define a mechanism by which obesity can lay the foundation for atherosclerosis and cardiovascular disease. Further, this will be useful in identifying obese patients at highest risk of developing cardiovascular disease, and thus may benefit the most from pharmaceutical or surgical intervention.One of the hallmarks of atherosclerosis is macrophage cholesterol efflux impairment which leads to intracellular accumulation of modified low-density lipoprotein (LDL) and subsequent formation of plaque forming lipid-rich foam cells. Macrophage cholesterol homeostasis is a delicate balance among influx, endogenous synthesis, esterification/hydrolysis and efflux. Even with this knowledge, it is unclear how obesity impairs cholesterol homeostasis. While the link between obesity and atherosclerosis is strong epidemiologically, large variations exist in individual responses to obesity. For example, some patients with high adiposity have normal cardiovascular health, while others with low adiposity have frank atherosclerosis. Exosomes are actively shed endocytic vesicles that transport lipids, sugars, nucleic acids, and proteins between cells at a distance. Exosomal function is largely determined by their microRNA content. MicroRNAs (miRNAs) are non-coding RNA (19–22 nucleotides) that post-transcriptionally regulate gene expression by base-pairing with the 3' untranslated region of complementary messenger RNA targets. The biological contexts that determine the exosomal microRNA-ome and their relationship to atherosclerosis remain to be clarified.
Simultaneous Multinuclear Magnetic Resonance Fingerprinting for Data Fusion of Quantitative Structural and Metabolic Imaging
The purpose of this study is to investigate a new method of magnetic resonance imaging (MRI) that could provide new information about the brain structure (gray and white matter) and its metabolism (how brain cells work). This technique could help improve our understanding of the human brain, and help researchers find new ways to treat and prevent brain disorders. MRI is a technique that provides images from inside the body (the head in this study) based on the magnetic properties of the tissues in the body. Traditional MRI machines create images of the human body by detecting the protons found in water molecules that are present in the body. This study will combine traditional proton MRI with a new technique called sodium MRI, which can detect the sodium atoms found in the salt molecules in the body. The idea is that by combining structural (from proton/water MRI) and metabolic (from sodium/salt MRI) imaging, and comparing the images of healthy subjects and subjects with chronic steno-occlusive disease and with recurrent transient ischemic attacks (TIA)/minor stroke, the study may gain insights which could help the doctors who treat patients with brain disorders make better treatment decisions. The imaging methods being evaluated are considered investigational, and some of the equipment used to obtain the images has not received approval from the United States Food and Drug Administration (FDA). .
Single-Center Pilot Study of Living Donor Kidney Transplant from HIV-positive Donor to HIV-positive Recipient
This study will evaluate the feasibility and safety of living donor kidney transplant from an HIV-infected donor to an HIV-infected recipient.
Single-center study of fiber tractography in brain tumor surgery
Magnetic resonance imaging (MRI) uses magnetic fields to create images which provide us with information about the structure and function of different tissues in the body. The purpose of this study is to develop MRI-based medical imaging technology to improve brain visualization for use in neurosurgery of brain tumor surgery patients. The researchers are evaluating a new imagining technique (ODF-Fingerprinting) to determine the value of this new methodology in brain surgery. At this time, only participants who are diagnosed with a glioma, a glioblastoma, a meningioma or brain metastases and are clinically scheduled for surgical brain tumor removal and a preoperative brain MRI scan are invited to participate.
Sinonasal Cancer | NYU Langone Health
Doctors at Perlmutter Cancer Center manage sinonasal cancer with surgery, radiation therapy, and chemotherapy.
Sinonasal Disorder Services for Children | NYU Langone Health
Specialists at Hassenfeld Children’s Hospital at NYU Langone create child-centered care plans to manage disorders affecting the nose and sinus.
Site for Randomized Phase II/III Trial of Surgery and Postoperative Radiation Delivered with Concurrent Cisplatin Versus Docetaxel Versus Docetaxel and Cetuximab for High-Risk Squamous Cell Cancer of the Head and Neck
The purpose of the study is to determine whether docetaxel alone is as active as docetaxel and cetuximab combination and whether either taxane-based regimen is better than cisplatin monotherapy. Participants will receive one of the following treatments: standard treatment (radiation therapy and cisplatin), experimental treatment (radiation therapy and docetaxel), or experimental treatment (radiation therapy, docetaxel, and cetuximab). All of the drugs are commercially available, however the combination of drugs in this study is considered experimental.