A randomized phase III study of neoadjuvant chemotherapy followed by surgery versus surgery alone for patients with High Risk RetroPeritoneal Sarcoma (STRASS 2)
In this study, patients will fill out Health-Related Quality of Life (HRQoL) questionnaires when they visit the hospital for their scheduled appointments. These questionnaires will follow the EORTC guidelines. The main copies will be sent to the hospitals, and if more copies or translations are needed, they can be requested from the EORTC contact person. Clinical report forms will ask if the HRQoL questionnaires were completed, and if they weren't, the reasons will be noted. Patients will receive the questionnaires from the doctor or a study nurse before their check-ups, and they should complete them on their own in their own language during the visit. A designated person, like a research nurse, will help make sure that patients fill out the questionnaires correctly and completely. The study will check how well patients follow through with completing the questionnaires at each visit, and this will be reviewed every six months and included in reports.
A Randomized single-blind placebo-controlled study on the effect of perioperative administration of ketamine on pain after surgery for orthopedic trauma: A Pilot Trial
The purpose of this study is to examine whether ketamine given during and after surgery (in the recovery room) can improve postoperative pain, mood, and postoperative recovery in patients who undergo orthopedic trauma surgery.
A RANDOMIZED TRIAL OF THE UTILITY OF RANDOM BIOPSIES IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE (THE URBI STUDY)
The purpose of this research study is to compare two different commonly used clinical care biopsy strategies for patients with longstanding Inflammatory Bowel Disease (IBD).
A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated with Interstitial Lung Disease (PH-ILD)
The purpose of this patient registry is to observe, characterize, and capture real-world data from patients with Group 3 pulmonary hypertension associated with interstitial lung disease (PH-ILD). Group 3 pulmonary hypertension (PH), defined as PH associated with chronic lung disease or hypoxia, is associated with higher morbidity, mortality, and medical costs than similar patients without PH (Barberà 2015). Past registries focus solely on PH or chronic lung disease individually and lack clinically relevant data of the alternate group, making it necessary for acombined group registry.
A Sibling Oocyte Study- Comparison of ZyMotTM Microfluidics Device to Density Gradient for Sperm Selection During ICSI
The primary purpose of this research is to evaluate whether ZyMot, a microfluidic sperm processing device, will lead to a higher percentage of better-quality embryos following insemination with intracytoplasmic sperm injection (ICSI) compared to sperm processed with density gradient, our standard sperm separation technique.
A single arm phase II study of ADjuvant Endocrine therapy subcutaneous Pertuzumab and Trastuzumab fixed-dose combination for patients with anatomic stage I hormone receptor-positive HER2-positive breast cancer (ADEPT)
This is a single arm open-label phase II trial of adjuvant Fixed Dose Combination (FDC) of subcutaneous (SC) trastuzumab (H) plus pertuzumab (P) and endocrine therapy without chemotherapy in patients with stage I hormone receptor-positive (HR+) and HER2-positive (HER2+) breast cancer. The primary endpoint is invasive disease-free survival when treated with a "de-escalated" regimen of hormonal and dual HER2-targeted therapy, with omission of a chemotherapy backbone. Eligible patients will have anatomic stage I (according to AJCC 8th edition anatomic staging table), HR+ and HER2+ breast cancer. HER2 positivity will be confirmed by central testing in all patients. Patients may be either pre- or post-menopausal. Patients must be naïve to systemic therapy for this cancer and have undergone primary breast surgery, with surgical pathology demonstrating stage I disease. After completion of primary breast surgery, patients will be registered to the trial, and receive adjuvant subcutaneous trastuzumab and pertuzumab (1 year), and hormonal therapy (at least 5 years). Patients will also receive adjuvant radiation therapy if deemed necessary per institutional practice. Patients will be followed for a total of 10 years for long-term disease outcomes. Patients will also participate in quality of life (QOL) surveys and symptom questionnaires at various time points through the course of study treatment and during follow-up. A subset of patients will participate in a single arm crossover substudy during four cycles of their overall therapy to receive two cycles of IV infusion followed by two cycles of SC FDC administration of HP, to specifically evaluate time and motion endpoints related to IV versus SC administration. Lastly, this study requires submission of tumor blocks or slides in order to perform biomarker analyses as well as blood draws for correlative analyses.
A single-center longitudinal study of the diagnosis clinical course risk factors causes and treatment of cognitive impairment in aging Alzheimer s disease (AD) and related disorders
The purpose is to study the diagnosis, clinical course, risk factors, causes and treatment of cognitive impairment in aging, Alzheimer’s disease (AD) and related disorders. AD patients and normal control subjects will be recruited to receive complete evaluations. These subjects, along with all previously evaluated subjects will be followed-up until death. Basic research on normal aging and the causes of AD will also be conducted. Eligible subjects include those with AD and related conditions, persons with mild cognitive impairment, and people with normal cognitive function for age.
A Single-Center Observational Barrier Assessment and Implementation of a Tailored Educational Intervention for Families of Children with Epilepsy in a Medically Underserved Population
This study aims to identify the socioeconomic/cultural disparities and patient perspective barriers in a medically underserved population (Bellevue Hospital). This will be followed by an implementation period with the design of an individualized educational intervention for families of patients with pediatric epilepsy. This pilot study will incorporate the use of questionnaires, data analysis, educational intervention development, social media, and videography to both assess the inequality experienced by this population and improve their health outcomes. Studies have evaluated the patient and family perspectives on epilepsy surgery, but there has been no study to our knowledge that incorporates an educational component built from these results.
A SINGLE-CENTER OBSERVATIONAL LONGITUDINAL STUDY ON THE EFFECT OF SLOW WAVE SLEEP (SWS) CHARACTERISTICS AND RACE AND ETHNICITY ON AMYLOID BURDEN (A MARKER OF ALZHEIMER S DISEASE RISK) AMONG COGNITIVELY NORMAL ELDERLY.
African-Americans (AAs) have an increased prevalence of both Alzheimer’s disease (AD) and vascular risk factors for AD such as diabetes and hypertension when compared to whites. This larger component of AD-dementia has traditionally been associated with vascular risk and supported by studies showing that AAs with clinical AD more frequently have mixed pathology on autopsy. However, in a recent community based study of non-demented elderly, black race was associated with higher amyloid burden after adjusting for vascular risk factors, suggesting the presence of additional physiological differences on AD-risk by race in the early stages of the disease. The purpose of this study is to test whether poor slow wave sleep (SWS) quantity (SWS duration) and quality (slow wave activity, SWA) is one of these physiological factors.
A single-center observational longitudinal study to monitor skeletal muscle aging with quantitative MRI
The muscles in your legs and shoulders change as you get older and they become weaker. The purpose of this study is to investigate new magnetic resonance imaging (MRI) techniques to look at these changes in your muscle over time. We will try and understand how changes in your muscle relate to muscle weakness, and whether there are differences in healthy people.