Airway, Breathing & Lung Conditions | NYU Langone Health
NYU Langone doctors specialize in treating infections and diseases of the lungs, including asthma, bronchitis, chronic cough, and lung cancer.
AKTive-001: A Phase 1/1b Multiple Cohort Trial of ALTA2618 in Patients with Advanced Solid Tumors with AKT1 E17K Mutation
This trial is designed to test the effectiveness of ALTA2618 in patients with advanced solid tumors that have a specific genetic mutation (AKT1 E17K). The study is divided into two parts: Phase 1, where the dose of ALTA2618 will be increased to find the maximum safe dose, and Phase 1b, where the drug will be tested in different groups of patients with specific types of cancer, like HR+/HER2-negative breast cancer and gynecological cancers. The trial will also look at how the drug works in the body (pharmacokinetics), its effect on the tumor, and how safe it is at different doses. In Phase 1, patients will receive the drug once daily, and the dose will be adjusted based on the safety and effectiveness data collected during the study. If patients show positive results, they may continue treatment even after the disease progresses. The study will continue until the best dose and treatment schedule are determined for further testing in Phase 2 trials.
Alcohol Septal Ablation for Hypertrophic Cardiomyopathy | NYU Langone Health
NYU Langone electrophysiologists may perform alcohol septal ablation, an alternative to surgical treatment for hypertrophic cardiomyopathy.
Alec C. Kimmelman, MD, PhD | NYU Langone Health
Alec C. Kimmelman, MD, PhD is dean and chief executive officer of NYU Langone Health.
Alexion NEPH-202 Ravulizumab trial
Chronic kidney disease (CKD) has become a worldwide public health issue due to its highincidence, poor prognosis, and substantial economic burden. When not properly diagnosed andmanaged, CKD can lead to many adverse outcomes such as end-stage renal disease (ESRD).Despite advances in immunosuppressive treatments, certain types of glomerulonephritis such aslupus nephritis (LN) and immunoglobulin A nephropathy (IgAN) continue to respond poorly totreatment, resulting over time in CKD. No disease-specific therapies are currently available,therefore effective treatments for managing LN and IgAN represent a high unmet medical need.The pathophysiology of glomerular diseases such as LN and IgAN involves a complex overlapof abnormal cellular immune response, loss of humoral immune tolerance, aberrant coagulation,and systemic inflammation. Complement dysregulation has emerged as an additional drivingfactor that interplays with these pathways in LN and IgAN. The narrow vessels and highperfusion in the kidney make this organ particularly susceptible to complement-mediated injury.Histologic evidence of complement deposition observed upon kidney biopsy of patients witheither LN or IgAN suggests a pathological role. This theory is supported by the association ofserum complement levels with disease activity and response to treatment, particularly in patientswith LN.The objectives of this study are to evaluate the safety and efficacy of ravulizumab(ULTOMIRIS®) administered by intravenous (IV) infusion compared to placebo anddemonstrate proof-of-concept of the efficacy of terminal complement inhibition in participantswith LN or IgAN.
Allergic & Contact Dermatology Services | NYU Langone Health
NYU Langone dermatologists specialize in the diagnosis and management of contact dermatitis and are expertly trained in patch testing.
Alzheimer’s Disease | NYU Langone Health
NYU Langone doctors diagnose people with Alzheimer’s disease and create a comprehensive plan for managing symptoms.
Alzheimer’s Disease & Related Dementias Family Support Program | NYU Langone Health
NYU Langone’s Alzheimer’s Disease and Related Dementias Family Support Program provides free services to family caregivers in New York City.
Alzheimer’s Disease Support | NYU Langone Health
NYU Langone specialists offer compassionate, supportive care for people with Alzheimer’s disease, their families, and caregivers.
Ambulatory Care Expansion | NYU Langone Health
NYU Langone’s reach is increasingly extending further into the surrounding neighborhood and region.