Huang Lab

Huang_photo

Chuanshu Huang, M.D., Ph.D.

Professor, Environmental Medicine and Deputy Director of Nelson Institute of Environmental Medicine
Departments of Environmental Medicine and Biochemistry and Molecular Pharmacology

Contact Info:

Address: 57 Old Forge Road, Tuxedo, NY 10987
Phone: 845-731-3519
Email: Chuanshu.Huang@nyumc.org

Key Interests

Cancer, Kinase and transcription factor activation, Gene expression, protein translation and modification, carcinogenesis and tumor chemoprevention, cancer invasion, metastasis and chemotherapy

Biographic Details:

Graduate Education: Fourth Milit Med Uni.  Medical and Graduate Education

Postdoctoral Training: University of Minnesota and NIOSH/CDC

Academic Appointments: Professor of Departments of Environmental Medicine, Biochemistry and Molecular Pharmacology

Major Responsibilities: Deputy Director of the Nelson Institute of Environmental Medicine

Research Interests:

Signal transduction involved in cellular function, tumor promotion, progression and cancer metastasis, and nutrient chemo-prevention. Reactive oxygen species (ROS) involved in cellular signaling and cancer development. Molecular mechanism of anti-cancer nutrients; Environment and carcinogenesis.

Selected Publications:

Superoxide plays critical roles in electrotaxis of fibrosarcoma cells via activation of ERK and reorganization of the cytoskeleton. Li, Fei; Wang, Hui; Li, Li; Huang, Chuanshu; Lin, Jiangkai; Zhu, Gang; Chen, Zhi; Wu, Nan; Feng, Hua. 2012 May;52(9):1888-1896, Free radical biology & medicine.— id: 166979, year: 2012, vol: 52, page: 1888, stat: Journal Article,

E3 Ligase Activity of XIAP RING Domain Is Required for XIAP-Mediated Cancer Cell Migration, but Not for Its RhoGDI Binding Activity. Liu, Jinyi; Zhang, Dongyun; Luo, Wenjing; Yu, Jianxiu; Li, Jingxia; Yu, Yonghui; Zhang, Xinhai; Chen, Jingyuan; Wu, Xue-Ru; Huang, Chuanshu. 2012 ;7(4):e35682-e35682 e35682, PLoS ONE.— id: 165633, year: 2012, vol: 7, page: e35682, stat: Journal Article,

RhoGDI SUMOylation at K138 Increases Its Binding Activity to Rho GTPase and its Inhibiting Cancer Cell Motility. Yu, J; Zhang, D; Liu, J; Li, J; Yu, Y; Wu, XR; Huang, C. 2012 Mar;:13752-13760, Journal of biological chemistry. — id: 162339, year: 2012, vol: , page: 13752, stat: Journal Article,

Suberoylanilide hydroxamic acid (SAHA) inhibits EGF-induced cell transformation via reduction of cyclin D1 mRNA stability. Zhang, Jingjie; Ouyang, Weiming; Li, Jingxia; Zhang, Dongyun; Yu, Yonghui; Wang, York; Li, Xuejun; Huang, Chuanshu. 2012 Sep;263(2):218-224, Toxicology & applied pharmacology. — id: 175777, year: 2012, vol: 263, page: 218, stat: Journal Article,

Urothelial tumor initiation requires deregulation of multiple signaling pathways: implications in target-based therapies. Zhou, H; Huang, HY; Shapiro, E; Lepor, H; Huang, WC; Mohammadi, M; Mohr, I; Tang, MS; Huang, C; Wu, XR. 2012 Feb;:770-780, Carcinogenesis. — id: 162340, year: 2012, vol: , page: 770, stat: Journal Article,

Cyclooxygenase-2 (COX-2) Mediates Arsenite Inhibition of UVB-Induced Cellular Apoptosis in Mouse Epidermal Cl41 Cells. Zuo, Z; Ouyang, W; Li, J; Costa, M; Huang, C. 2012 Jul;12(6):607-616, Current cancer drug targets. — id: 170417, year: 2012, vol: 12, page: 607, stat: Journal Article,

Hexavalent Chromium Cr(VI) Up-Regulates COX-2 Expression through an NFkappaB/c-Jun/AP-1-Dependent Pathway. Zuo, Zhenghong; Cai, Tongjian; Li, Jingxia; Zhang, Dongyun; Yu, Yonghui; Huang, Chuanshu. 2012 Apr;120(4):547-553, Environmental health perspectives. — id: 163589, year: 2012, vol: 120, page: 547, stat: Journal Article,

See All Publications

Lab Members:

Jingxia Li 
Honglei Jin 
Junlan Zhu 
Jiawei Xu 
Yang Li 
Chao Huang 
Minggang Peng 
Xirui Guo 
Haiyang Zhu 
Lei Xue 
Jing An 
Xin Liao 
Chengfan Zhou 
Zhongxian Tian 
Xiaohui Hua 
Jiheng Xu 
Daimin Xiang 

Alumni:

Lun Song, Ph.D. 
Wenjing Luo, Ph.D. 
Weimin Ouyang, Ph.D. 
Qinsong Tong, Ph.D. 
Jinyi Liu, Ph.D. 
Jin Ding, Ph.D. 
Haishan Huang, Ph.D. 
Dongyun Zhang, Ph.D. 
Guosong Jiang, Ph.D. 
Ruowen Zhang, Ph.D. 
Guangxuan Gao, Ph.D. 
Haitian Lu, Ph.D. 
Ja'Wanda Grant, Ph.D. 
Jianxiu Yu, Ph.D. 
Yulei Wang, Ph.D. 
Xun Che, MS 
Liang Chen, MS 
Jinlong Wei, MS 
Tongjian Cai, Ph.D. 
Zhenghong Zuo, Ph.D. 
Xinhai Zhang, Ph.D. 
Yonghui Yu, Ph.D. 
Tae Hyung Kim, Ph.D. 
Li Ma, Ph.D. 
Wei Guo, Ph.D. 
Jingjie Zhang, Ph.D. 
Zipeng Cao, M.D. 
Xueyong Li, M.D. & Ph.D. 
Xuewei Zhao, M.D. & Ph.D. 
Xiaoyi Mi, M.D. & Ph.D.