December 2012 Researcher of the Month - Jinghua Zhang

Jinghua Zhang

Current Research
I am working as a Senior Staff Associate and Assistant Research Scientist with the Diabetes Research Program. My research focuses on the interface of diabetes and genetic modifications via RAGE.

1.  Rai V, Touré F, Chitayat S, Pei R, Song F, Li Q, Zhang J, Rosario R, Ramasamy R, Chazin WJ, Schmidt AM. Lysophosphatidic acid targets vascular and oncogenic pathways via RAGE signaling. J Exp Med. 2012 doi:10.1084/jem.20120873.

2.  Juranek JK, Geddis MS, Song F, Zhang J, Garcia J, Rosario R, Yan SF, Brannagan TH, Schmidt AM.  RAGE Deficiency Improves Postinjury Sciatic Nerve Regeneration in Type 1 Diabetic Mice. Diabetes. 2012 Nov 19. [Epub ahead of print]

3.  Mann MA, Das S, Zhang J, Wagner M, Fischbach GD.  Neuregulin effect on quantal content dissociated from effect on miniature endplate potential amplitude.  J Neurophysiol. 96(2):671-6, 2006.

4.  Annuziato PW, Lungu O, Zhang J,  Panagiotidis C, Silver DN, Gershon AA, Silverstein SJ.  Varicella-Zoster virus proteins in skin lesions: implications for a novel role of ORF29p in Chickenpox.  J. Viol.  74:2005-2010, 2000.

5.  Miyata T, Hori O, Yan S, Zhang J,  Ferran L, Lida Y, Schmidt  AM.  The receptor for advanced glycation end products (RAGE)
is acentral mediator of the interaction of AGE-B2 microglobulin with human mononuclear phagocytes via an oxidant-sensitive pathway: implictions for the pathogenesis of dialysis-related amyloidosis.  J. Clin. Invest.  98(5):1088-1094, 1996.

6.  Hori O, Brett J, Slattery T, Cao R, Zhang J, Chen J, Nagashima M, Lundh ER, Vijay S, Niteki D, Morser J, Stern D Schmidt AM.  The receptor for advanced glycation end products(RAGE) is a cellular binding site for amphoterin: mediation of nutrite outgrowth and co-expression of RAGE and amphoteirn in the developing nervous system, J. Biol. Chem.  2780:25752-25761, 1995.

7.  Schmidt AM, Hasu M, Popov D, Zhang J, Chen J, Yan SD, Brett J, Stern D.  Advanced glycation end products interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice: a potential mechanism for the accelerated vasculopathy of diabetes. J. Clin. Invest. 96:1395-1403, 1995.

8.  Schmidt AM, Hasu M, Popov D, Zhang J, Chen J, Yan S, Brett J, Kuwabara K, Costache G.  Receptor for advanced glycation end products (AGEs) has a central role in vessel wall interactions and gene activation in response to circulating AGE proteins.  PNAS  91:8807-8811, 1994.

9.  Yan S, Schmidt  AM, Zhang J, Brett J, Zou Y, Pinsky D, Stern D.  Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins.  J. Biol. Chem.  269:9889-9897, 1994.

10.  Schmidt AM, Yan S, Zhang J, Brett J, Stern D.  Advanced glycation endproducts (AGEs) result in increased production of mesangial cell transforming growth factor via a mechanism dependent on the receptor for AGE (RAGE).   American Heart Association 66th Scientific Sessions, Atlanta, Nov. 8-11, 1993.

Future Plans
My current research entails investigating RAGE blocking molecules and their further characterization.  It is my hope that these studies will lead to new therapies for treating diabetes and its complications.