February 2016 Researcher of the Month - Fei Song, MD

Current ResearchFei Song, MD
My research focuses on the receptor for advanced glycation end products (RAGE) and diet-induced obesity/diabetes mellitus. It involves studying how glucose and lipid homeostasis is regulated by RAGE, as well as investigating how RAGE influences the “cross-talk” between different organs and tissues. Recently, I am working on RAGE impact on microbiome.

1. Daffu G, Shen X, Senatus L, Thiagarajan D, Abedini A, Hurtado Del Pozo C, Rosario R, Song F, Friedman RA, Ramasamy R, Schmidt AM. RAGE Suppresses ABCG1-Mediated Macrophage Cholesterol Efflux in Diabetes. Diabetes. 2015 Dec; 64(12):4046-60. doi: 10.2337/db15-0575.

2. Song F, Hurtado del Pozo C, Rosario R, Zou YS, Ananthakrishnan R, Xu X, Patel PR, Benoit VM, Yan SF, Li H, Friedman RA, Kim JK, Ramasamy R, Ferrante AW Jr, Schmidt AM. RAGE regulates the metabolic and inflammatory response to high-fat feeding in mice. Diabetes. 2014 Jun; 63(6):1948-65. doi: 10.2337/db13-1636.

3. Rai V, Touré F, Chitayat S, Pei R, Song F, Li Q, Zhang J, Rosario R, Ramasamy R, Chazin WJ, Schmidt AM. Lysophosphatidic acid targets vascular and oncogenic pathways via RAGE signaling. J Exp Med. 2012 Dec 17; 209(13):2339-50. doi: 10.1084/jem.20120873.

4. Juranek JK, Geddis MS, Song F, Zhang J, Garcia J, Rosario R, Yan SF, Brannagan TH, Schmidt AM. RAGE deficiency improves postinjury sciatic nerve regeneration in type 1 diabetic mice. Diabetes. 2013 Mar; 62(3):931-43. doi: 10.2337/db12-0632.

5. Song F, Schmidt AM. Glycation and insulin resistance: novel mechanisms and unique targets? Arterioscler Thromb Vasc Biol. 2012 Aug; 32(8):1760-5. doi: 10.1161/ATVBAHA.111.241877. Review.

6. Ma W, Rai V, Hudson BI, Song F, Schmidt AM, Barile GR. RAGE binds C1q and enhances C1q-mediated phagocytosis. Cell Immunol. 2012; 274(1-2):72-82. doi: 10.1016/j.cellimm.2012.02.001.

7. Juranek JK, Aleshin A, Rattigan EM, Johnson L, Qu W, Song F, Ananthakrishnan R, Quadri N, Yan SD, Ramasamy R, Schmidt AM, Geddis MS. Morphological Changes and Immunohistochemical Expression of RAGE and its Ligands in the Sciatic Nerve of Hyperglycemic Pig (Sus Scrofa). Biochem Insights. 2010 Sep 1; 2010(3):47-59.

8. Reiniger N, Lau K, McCalla D, Eby B, Cheng B, Lu Y, Qu W, Quadri N, Ananthakrishnan R, Furmansky M, Rosario R, Song F, Rai V, Weinberg A, Friedman R, Ramasamy R, D'Agati V, Schmidt AM. Deletion of the receptor for advanced glycation end products reduces glomerulosclerosis and preserves renal function in the diabetic OVE26 mouse. Diabetes. 2010 Aug; 59(8):2043-54. doi: 10.2337/db09-1766. Epub 2010 Jul 13.

9. Xu Y, Toure F, Qu W, Lin L, Song F, Shen X, Rosario R, Garcia J, Schmidt AM, Yan SF. Advanced glycation end product (AGE)-receptor for AGE (RAGE) signaling and up-regulation of Egr-1 in hypoxic macrophages. J Biol Chem. 2010 Jul 23; 285(30):23233-40. doi: 10.1074/jbc.M110.117457.

10. Bucciarelli LG, Ananthakrishnan R, Hwang YC, Kaneko M, Song F, Sell DR, Strauch C, Monnier VM, Yan SF, Schmidt AM, Ramasamy R. RAGE and modulation of ischemic injury in the diabetic myocardium. Diabetes. 2008 Jul; 57(7):1941-51. doi: 10.2337/db07-0326.

11. Aleshin A, Ananthakrishnan R, Li Q, Rosario R, Lu Y, Qu W, Song F, Bakr S, Szabolcs M, D'Agati V, Liu R, Homma S, Schmidt AM, Yan SF, Ramasamy R. RAGE modulates myocardial injury consequent to LAD infarction via impact on JNK and STAT signaling in a murine model. Am J Physiol Heart Circ Physiol. 2008 Apr; 294(4):H1823-32. doi: 10.1152/ajpheart.01210.2007.

12. Toth C, Rong LL, Yang C, Martinez J, Song F, Ramji N, Brussee V, Liu W, Durand J, Nguyen MD, Schmidt AM, Zochodne DW. Receptor for advanced glycation end products (RAGEs) and experimental diabetic neuropathy. Diabetes. 2008 Apr; 57(4):1002-17. Epub 2007 Nov 26. Retraction in: Diabetes. 2014 May; 63(5):1817.

13. Bucciarelli LG, Kaneko M, Ananthakrishnan R, Harja E, Lee LK, Hwang YC, Lerner S, Bakr S, Li Q, Lu Y, Song F, Qu W, Gomez T, Zou YS, Yan SF, Schmidt AM, Ramasamy R. Receptor for advanced-glycation end products: key modulator of myocardial ischemic injury. Circulation. 2006 Mar 7; 113(9):1226-34.

Future Plans
The discovery of the important role(s) RAGE plays in attenuating metabolic dysregulation induced by chronic energy imbalance (diet-induced obesity) has led to more fundamental questions regarding the function of RAGE in basic metabolic homeostasis.