Devi Thiagarajan, PhD

Devi Thiagarajan, PhDAs a postdoctoral fellow in the Diabetes Research Program, my main focus was to understand the role of Aldose Reductase (AR) in mediating secondary complications in the heart and to underpinning the mechanisms related to it. My contribution was in delineating the epigenetic mechanisms associated with increased polyol pathway and how it results in ectopic lipid accumulation in the heart.

I am currently working as a research associate at University of Southern California, Los Angeles. My present work involves understanding the epigenetic events leading to increased susceptibility of the aging population to cancer. I am also interested in understanding the epigenetic mechanisms related to aging.

Publications:
1.  Vedantham S, Thiagarajan D, Ananthakrishnan R, Wang L, Rosario R, Zou YS, Goldberg I, Yan SF, Schmidt AM, Ramasamy R. Aldose reductase drives hyperacetylation of Egr-1 in hyperglycemia and consequent upregulation of proinflammatory and prothrombotic signals. Diabetes. 2014 Feb; 63(2):761-74.

2.  Suri D, Veenit V, Sarkar A, Thiagarajan D, Kumar A, Nestler EJ, Galande S, Vaidya VA. Early stress evokes age-dependent biphasic changes in hippocampal neurogenesis, BDNF expression, and cognition. Biol Psychiatry. 2013 Apr 1; 73(7):658-66.

3. Thiagarajan D, Dev RR, Khosla S. The DNA methyltranferase Dnmt2 participates in RNA processing during cellular stress. Epigenetics. 2011 Jan; 6(1):103-13.

4.  Sowpati DT, Thiagarajan D, Sharma S, Sultana H, John R, Surani A, Mishra RK, Khosla S. An intronic DNA sequence within the mouse Neuronatin gene exhibits biochemical characteristics of an ICR and acts as a transcriptional activator in Drosophila. Mech Dev. 2008 Nov-Dec; 125(11-12):963- 73.