Gopalkrishna Sreejit, PhD, Postdoctoral Fellow

Gopalkrishna Sreejit, Postdoctoral Fellow

I obtained my MSc degree from MG University, Kerala in India.  I received my PhD from CDFD in Hyderabad, India.  The topic of my PhD thesis was the subversion of macrophage immune responses by secreted proteins of Mycobacterium tuberculosis.

During my postdoctoral studies, I identified a novel mechanism used by Mycobacterium tuberculosis to modulate antigen presentation by host cell to prevent subsequent development of an immune response against the intracellular pathogen.

As a member of the Diabetes Research Program, my studies include working on the mechanism by which Aldose Reductase and RAGE pathways modulate metabolic dysfunction and impairs stress response in aging and diabetic hearts.

Publications
Gopalkrishna Sreejit, Asma Ahmed, Nazia Parveen, Vishwanath Jha, Vijaya Lakshmi Valluri, Sudip Ghosh and Sangita Mukhopadhyay.   The ESAT-6 protein of Mycobacterium tuberculosis interacts with beta-2-microglobulin (β2M) affecting antigen presentation function of macrophage.  PLoS Pathog. 2014 Oct 30;10 (10):e1004446.
doi: 10.1371/journal.ppat.1004446.