Schneider Lab - Microbiology

Robert J. Schneider, Ph.D.
Albert Sabin Professor of Microbiology and Molecular Pathogenesis

Departments of Microbiology and Radiation Oncology

Medical Science Building
, Room 238
550 First Avenue, New York, NY 10016

Office: (212) 263-6006
Fax: (212) 263-8276
Email: schner01@med.nyu.edu

 

 

KEY INTERESTS:  human cancer, breast cancer, translational regulation, inflammation, mRNA stability, translational research, clinical trials

BIOGRAPHIC DETAILS:

Graduate Education:

Mt. Sinai School of Medicine, NY

Postdoctoral Training:

Princeton University

Academic Appointments:

Albert Sabin Professor of Molecular Pathogenesis and Microbiology,
Professor of Radiation Oncology,
Director of Translational Cancer Research,
Co-director of Breast Cancer Research Program,
Associate Director of the Perlmutter Cancer Center

Major Responsibilities:

Director of Translational Cancer Research Program,
Co-Director of Breast Cancer Research Program, Breast cancer clinical trials,
Director of Infectious Disease and Microbiology training program

Major Honors (selected):

2010 Judah Folkman Memorial lecture, Chemotherapy Foundation
2010 Director of the International Consortium for Inflammatory Breast Cancer
2010 Emmy award ABC-TV special “Breast Cancer: New Protocols & Greater Hope”
2010 Department of Defense Advisory Council for Breast Cancer Research Program
2010 Chair of the Avon Foundation International Breast Cancer Conference
2010 Board of Directors, Susan G. Komen Breast Cancer Foundation, New York affiliate
2011 Distinguished Alumnus Award & Commencement address: University of Delaware

RESEARCH INTERESTS:

I conduct research in two areas.  One research program is directed to the development, progression and metastasis of breast cancer, the interplay of the inflammatory response in human cancer and development of new clinical therapeutics and clinical trials based on this work.  This research effort is directed to the molecular and genetic understanding of advanced breast cancers.  Much of my research is focused on the molecular basis of locally advanced breast and inflammatory breast cancers, and their progression to metastatic disease, particularly the major role of translational regulation in these processes.  We investigate the specific alterations in the mTOR signal transduction pathway, translation factor alterations a microRNAs in human breast cancer, which informs our translational and clinical research and development of novel clinical trials.  Our research has played a significant role in the development of small molecule inhibitors of selective oncogenic mRNA translation, one of which is in phase 2 clinical trials.  A second research program is focused on a molecular understanding of gene regulation by targeted accelerated mRNA decay, particularly in inflammatory cytokine expression controlled by the gene AUF1.  This research involves the numerous intersections of control of rapid mRNA decay with human disease and exposure to radiation, including cancer, inflammatory disorders and accelerated aging.  In both major project areas we develop animal models of human disease. 

PUBLICATIONS: (2008 – present only)

The role of health system factors in delaying final diagnosis and treatment of breast cancer in Mexico City, Mexico.
Bright, K., Barghash, M., Donach, M., Gutierrez de Barrera, M.; Schneider, R.J. and Formenti, S.C.. (2011)
Breast Journal, in press.

Interstitial fluid pressure correlates with intra-voxel incoherent motion imaging metrics in a mouse mammary carcinoma model.
S. Kim, L. Decarlo, G. Y. Cho, J. H. Jensen, D. K. Sodickson, L. Moy, S. Formenti, R. J. Schneider, J. D. Goldberg, E. E. Sigmund (2011).
In press.

Translational control in cancer.
Silvera, D., Formenti, S.C. and Schneider, R.J. (2010).
Nature Reviews Cancer 10:254-266.

Identification of markers of taxane-sensitivity through proteomic and genomic analyses of breast tumors from patients receiving neoadjuvant paclitaxel/radiation therapy.
Bauer, J.A., Bapsi Chakravarthy, A., Rosenbluth, J.M., Mi, D., Seeley, E.H., De Matos Granja, N., Olivares, M.G., Kelley, M.C., Mayer, I.A., Meszoely, I.M., Means-Powell, J.A., Johnson, K.N., Tsai, C.J., Ayers,G.D., Sanders, M.E., Schneider, R.J., Formenti, S.C., Caprioli, R.M., and Pietenpol, J.A. (2010).
Clinical Cancer Research 16:680-690.

Androgen receptor coactivator p44/Mep50 in breast cancer growth and invasion.
Peng, Y., Li, Y., Gellert, L.L., Zou, X., Wang, J., Singh, B., Xu, R., Chiriboga, L., Daniels, G., Pan, R., Zhang, D.Y., Garabedian, M.J., Schneider, R.J., Wang, Z,, Lee, P. (2010).
Journal of Celllar and Molecular Medicine.

Low-dose radiation augments vasculogenesis signaling through HIF-1 dependent and independent SDF-1 induction.
Lerman, O.Z., Greives, M.R., Thanik, V.D., Singh, S.P., Chang, C.C., Seiser, N., Brown, D.J., Schneider, R.J., Formenti, S.C., Saadeh, P.B. and Levine, J.P. (2010).
Blood 116:3669-3676.

AUF1 is involved in splenic follicular B cell maintenance.
Sadri, N., Lu, J.-Y., Badura, M. and Schneider, R.J. (2010).
BMC Immunology 11: 1-14.

Mitotic raptor promotes mTORC1 activity, G2/M cell cycle progression and IRES-dependent mRNA translation.
Ramírez-Valle, F., Badura, M.,  Braunstein S. and Schneider, R.J. (2010).
Mol. Cell. Biol., 30:3151-3164.

Cutaneous low-dose radiation increases tissue vascularity through upregulation of angiogenic and vasculogenic pathways.
Thanik VD, Chang CC, Lerman OZ, Greives MR, Le H, Warren SM, Schneider R.J., Formenti SC, Saadeh PB, Levine JP. (2010).
J. Vasc. Res. 47(6):472-480.

Late-stage breast cancer gene signature and selective drug resistance unveiled by expression of the Hsp90 co-chaperone p23.
Simpson, N.E., Lambert, N.W., Watkins, R., Giashuddin, S., Huang, S.J., Oxelmark, E., Arj, R., Hochman, T., Goldberg, J.D., Schneider, R.J., Reiz, L.F.L., Soares, F.A., Logan, S.K. and Garabedian, M.J. (2010).
Cancer Res. 70:8446-8456.

Five-Year Results of Preoperative Paclitaxel with Concurrent Radiation Therapy In Locally Advanced Breast Cancer: Pathological Response Predicts For Survival.
Adams, S., Bapsi Chakravarthy, A.,Donach, M., Spicer, D., Lymberis, S., Singh, B., Bauer, J.A., Hochman, T., Goldberg, J.D., Muggia, F., Schneider, R.J., Pietenpol, J.A., and Formenti, S.C. (2010).
Breast Cancer Res. & Treat. 124:723-732.

Distinct function of androgen receptor coactivator ARA70alpha and ARA70beta in mammary gland development and breast cancer.
Wu, X., Chen, F.,Sahin, A., Albarracin, Pei, Z., Zou, X., Singh, B., Xu, R., Daniels, G., Li, Y., Wei, J., Blake, M., Schneider, R.J., Cowin, P., Lee, P.(2010).
Breast Cancer Res. Treat.

Dose-dependent effect of radiation on angiogenic and angiostatic CXC chemokine expression in human endothelial cells.
Chang, C.C., Lerman, O.Z., Thanik, V.D., Scharf, C.L., Greives, M.R., Schneider, R.J., Formenti, Saadeh, P.B., Warren, S.M. and Levine, J.P. (2009).
Cytokine 48:295-302.

Regulation of protein synthesis by ionizing radiation.
Braunstein, S., Badura, M., Xi, Q., Formenti, S.C. and Schneider, R.J. (2009).
Mol. Cell. Biol. 29: 5645-5656.

Inflammatory breast cancer cells are constitutively adapted to hypoxia.
Silvera, D. and Schneider, R.J. (2009).
Cell Cycle 19: 3089-3094.  Cover paper.

The regulation of protein synthesis in cancer, in "Translational Control in Health and Disease", in series Progress in Molecular Biology and Translational Science.
Cuesta, R., Gupta, M. and Schneider. R.J. (2009)
Ed. J.W.B. Hershey, Elsevier Press.

Auf1/Hnrnpd-deficient mice develop pruritic inflammatory skin disease.
Sadri, N. and Schneider, R.J.(2009).
J. Invest. Derm. 129, 657–670.

TNF selects for stable inducible upregulation of NF-kB linked to radiation resistance in weakly transformed breast cancer cells.
Braunstein, S., Formenti, S. C. and Schneider, R.J. (2008).
Mol. Cancer Res. 6:78-88.

eIF4GI Links Nutrient Sensing by mTOR to Cell Proliferation and Inhibition of Autophagy.
Ramírez-Valle, F. Braunstein S., Zavadil, J., Formenti, S.C., and Schneider, R.J. (2008).
J. Cell Biol. 181: 293-307.

AUF1 interacts with members of the nurd chromatin remodeling complex in the developing rat cortex.
Lee, C., Gyorgy, A., Maric, D., Sadri, N., Schneider, R.J., Barker, J.L., Lawson, M. and Agoston, D.V., (2008).
Cerebral Cortex 18: 2909-2919.

Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells.
Matsumura, S., Wang. B., Kawashima, N., Braunstein, S., Badura, M., Cameron, T.O., Babb, J.S., Schneider, R.J., Formenti, S.C., Dustin, M.L. and Demaira, S. (2008).
J. Immunology 181: 3099-3107.

Glioma-like proliferation within tissues excised as tubers in patients with tuberous sclerosis complex.
Fischer, I., Cunliffe, C., Bollo, R. J., Weiner, H. L., Devinsky, O., Ruiz-Tachiquin, M. E., Venuto, T., Pearlman, A., Chiriboga, L., Schneider, R.J., Ostrer, H., Miller, D. C. (2008),
Acta Neuropathol. 116: 67-77.

 

LAB MEMBERS:

Graduate Students

Devon Chenette
Lindsey Decarlo
George Hsu
Amanda Valeta

Postdoctoral and In-lab Clinical Research Associates

Amandine Alard
Rezina Arju
Michelle Badura
Eileen Connolly
Shughada Dhage
Malavika Gupta
Martijn Keddes
Sharmilee Korets
Fernanda Musa
Raphael Questa
Faisal Ronny
Rajni Sethi
Deborah Silvera
Viviana Volta