Possemato Lab News & Awards
Read the latest news about members of the Possemato Lab.
Lab member Jong Shin published a new paper, Allosteric regulation of CAD modulates de novo pyrimidine synthesis during the cell cycle, in the journal Nature Metabolism. Cells adjust which molecules they produce to meet changing needs. We describe how the enzyme CAD evolved in animals to sense whether cells have enough DNA building blocks to grow and divide. Read a News & Views preview written by nucleotide synthesis expert Issam Ben-Sahra.
Lab member Elizabeth Gorodetsky received an NIH Ruth L. Kirschstein National Research Service Award!
Lab member Marte Molenaars received Human Frontier Science Program Postdoctoral Fellowship!
Lab member Marte Molenaars received EMBO Postdoctoral Fellowship!
Lab member Erdem Terzi published a new paper, Iron-sulfur cluster deficiency can be sensed by IRP2 and regulates iron homeostasis and sensitivity to ferroptosis independent of IRP1 and FBXL5, in the journal Science Advances. Cells must carefully manage iron to prevent oxidative damage and cell death. A specific cellular component, IRP2, regulates iron levels in a way that may be dysregulated in an inherited neurodegenerative disease.
Lab member Vlad Sviderskiy published a new paper, Hyperactive CDK2 activity in basal-like breast cancer imposes a genome integrity liability that can be exploited by targeting DNA polymerase epsilon, in the journal Molecular Cell. A difficult-to-treat type of breast cancer, basal-like, is unusually sensitive to inhibition of a gene involved in DNA duplication, POLE1. Cancer promoting changes typically present in this tumor type were identified as factors that cause sensitivity to POLE1 inhibition.
Summer Student Takaharu Araki named a 2020 Regeneron STS Scholar! Taka has investigated the impact of oxygen and mTORC1 activation on central carbon metabolism under the mentorship of Jong Shin.
Possemato Lab Receives American Cancer Society Research Scholar Grant
Lab member Vlad Sviderskiy received an NIH Ruth L. Kirschstein National Research Service Award!
Lab member Vlad Sviderskiy selected to attend the Lindau Nobel Laureate Meeting. Vlad, an MD/PhD student, was selected in a competition to attend this prestigious meeting in Lindau, Germany, where he will have the opportunity meet current and past Nobel Laureates. Perhaps someday they will be his peers!
Lab members Minwoo Nam, Daniel McLaughlin, and Denise Minton published a new paper, Serine Catabolism by SHMT2 is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl tRNAs, in the journal Molecular Cell. Serine catabolic enzyme SHMT2 contributes one carbon units required for the production of mitochondrial initiator tRNA formylation. SHMT2 loss impacts mitochondrial translation, depleting mitochondrially encoded proteins and decreasing respiration.
Press Release: New Way to Target Lung Tumors Unveiled Through Creative Research
A protein’s role in helping such cancers respond to their environment may be a key to innovative therapies.
Dr. Possemato has received the following awards:
- 2019 Above and Beyond Mentorship Award
- 2018 AACR NextGen Star
- 2016 Pew-Stewart Scholar for Cancer Research
- 2015 Susan G. Komen Career Catalyst
- 2015 V Foundation V Scholar Award
- 2012 K99/R00 Transition to Independence Award, NIH
- 2011 Margaret and Herman Sokol Post-Doctoral Award, Whitehead Institute
- 2009 Susan G. Komen Post-Doctoral Fellowship
- 2002 Howard Hughes Medical Institute Predoctoral Fellowship