Possemato Lab Publications

Members of the Possemato Lab frequently publish their work in leading peer-reviewed journals. Read the latest papers to learn more about their work.

Recent Publications

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

Alvarez, Samantha W; Sviderskiy, Vladislav O; Terzi, Erdem M; Papagiannakopoulos, Thales; Moreira, Andre L; Adams, Sylvia; Sabatini, David M; Birsoy, Kivanc; Possemato, Richard

Nature. 2017 11 30; 551:639-643

Iron-sulfur cluster deficiency can be sensed by IRP2 and regulates iron homeostasis and sensitivity to ferroptosis independent of IRP1 and FBXL5

Terzi, Erdem M; Sviderskiy, Vladislav O; Alvarez, Samantha W; Whiten, Gabrielle C; Possemato, Richard

Science advances. 2021 May ; 7:

Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase Îµ

Sviderskiy, Vladislav O; Blumenberg, Lili; Gorodetsky, Elizabeth; Karakousi, Triantafyllia R; Hirsh, Nicole; Alvarez, Samantha W; Terzi, Erdem M; Kaparos, Efiyenia; Whiten, Gabrielle C; Ssebyala, Shakirah; Tonzi, Peter; Mir, Hannan; Neel, Benjamin G; Huang, Tony T; Adams, Sylvia; Ruggles, Kelly V; Possemato, Richard

Molecular cell. 2020 Nov 19; 80:682-698.e7

Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs

Minton, Denise R; Nam, Minwoo; McLaughlin, Daniel J; Shin, Jong; Bayraktar, Erol C; Alvarez, Samantha W; Sviderskiy, Vladislav O; Papagiannakopoulos, Thales; Sabatini, David M; Birsoy, KÄ±vanÃ§; Possemato, Richard

Molecular cell. 2018 02 15; 69:610-621.e5

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

Possemato, Richard; Marks, Kevin M; Shaul, Yoav D; Pacold, Michael E; Kim, Dohoon; Birsoy, Kivanc; Sethumadhavan, Shalini; Woo, Hin-Koon; Jang, Hyun G; Jha, Abhishek K; Chen, Walter W; Barrett, Francesca G; Stransky, Nicolas; Tsun, Zhi-Yang; Cowley, Glenn S; Barretina, Jordi; Kalaany, Nada Y; Hsu, Peggy P; Ottina, Kathleen; Chan, Albert M; Yuan, Bingbing; Garraway, Levi A; Root, David E; Mino-Kenudson, Mari; Brachtel, Elena F; Driggers, Edward M; Sabatini, David M

Nature. 2011 Aug 18; 476:346-50

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

Birsoy, Kivanc; Possemato, Richard; Lorbeer, Franziska K; Bayraktar, Erol C; Thiru, Prathapan; Yucel, Burcu; Wang, Tim; Chen, Walter W; Clish, Clary B; Sabatini, David M

Nature. 2014 Apr 03; 508:108-12

Amino acid management in cancer

Tsun, Zhi-Yang; Possemato, Richard

Seminars in cell & developmental biology. 2015 Jul ; 43:22-32

Iron-sulfur cluster metabolism impacts iron homeostasis, ferroptosis sensitivity, and human disease

Sviderskiy, Vladislav O.; Terzi, Erdem M.; Possemato, Richard

[S.l.] : Springer International Publishing, 2019. p.215-237. (4508572)

Possemato Lab Publications | NYU Langone Health