NYU Langone’s Rodent Genetic Engineering Laboratory (RRID:SCR_017925) is a resource for researchers who want to apply advanced molecular genetic techniques in rodent models of physiology and disease. Our lab is experienced at generating novel mutant and transgenic mouse strains using genome engineering in mouse embryos and in embryonic stem cells (ESCs).

To reserve time on an instrument, faculty, staff, and investigators must be registered in iLab. We have also provided iLab login instructions for NYU Langone, NYU, NYU College of Dentistry, and external users.

Our lab scientists customize technologies to meet individual project needs. Available technologies include:

• Generation of genome-edited mice by embryo pronuclear microinjection of DNA and genome editors (e.g., CRISPR/Cas9, site-specific recombinases) or traditional BAC transgenesis.
• Generation of genome-edited mice from mouse embryonic stem cells (mESCs) by chimeric blastocyst injection.
• Generation of genome-edited mice from mESCs by tetraploid blastocyst injection.
• Gene targeting in mESCs using electroporation, including Knock-in into the Rosa26 and other safe harbors.
• Generation of mice from induced pluripotent stem cells.
• Assisted reproductive technologies.
• Sperm and embryo cryopreservation, storage and import/export.
• in vitro fertilization (IVF)
• Embryo rederivation technologies for animal import into barrier vivaria through quarantine.

Contact Us

Our Rodent Genetic Engineering Laboratory locations are in room 447 of the Science Building; and in the barrier vivarium on the third floor of the Science Building.

For inquiries, email Ran Brosh, PhD, at Ran.Brosh@NYULangone.org.

How to Acknowledge the Rodent Genetic Engineering Laboratory

If you have collaborated with our laboratory and utilized our instruments, technologies, expertise, or data and your results are published or presented in a grant application, media release, or any other form of media, acknowledgment of the Rodent Genetic Engineering Laboratory (RRID:SCR_017925) and all supporting grants is a requirement.

Please sign an acknowledgment form, indicating that you have read and understand our policy, and email it to Ran Brosh, PhD, at Ran.Brosh@NYULangone.org.

NYU Langone’s Laura and Isaac Perlmutter Cancer Center Support Grant National Institutes of Health/National Cancer Institute P30CA016087 partially supports the Rodent Genetic Engineering Laboratory. Acknowledgment of this grant is a requirement for all publications resulting from research collaboration with our Rodent Genetic Engineering Laboratory or use of our technologies. Additionally, all such publications are required to abide by National Institutes of Health Public Access Policy and deposited in PubMed Central^®.