Rifkin Lab | NYU Langone Health

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Rifkin Lab

Our researchers study how transforming growth factor-β is regulated.

The major research interest of the Rifkin Lab at NYU Langone is the transfer of information in the extracellular environment and the impact of this process on diseases such as cancer.

As a model to study how extracellular molecular cues are processed, we have chosen to examine the manner in which growth factors are presented to their receptors. While at first thought this may appear to be straightforward, the interaction of a growth factor with its receptor occurs only under specific conditions: growth factor diffusion must be controlled to ensure that sufficiently high concentrations are reached, many growth factors must be activated before binding to their cognate receptor, and growth factors’ function is highly contextual.

Microscopic Image of Wilt Type Mouse Aortic Smooth Muscle Cells
Immunofluorescent staining of wild type mouse aortic smooth muscle cells showing the colocalization of LTBP1 (red) and fibrillin (yellow) to form orange structures.

These facts make the problem of understanding growth factor availability in both time and space interesting and challenging. Indeed, improper growth factor presentation may be the cause of a number of pathologies including tumor growth, fibrosis, and autoimmunity.

Contact Us

Daniel B. Rifkin, PhD
Principal Investigator
Professor, Department of Cell Biology
The Charles Aden Poindexter Professor of Medicine, Department of Medicine
550 First Avenue, MSB 638
New York, NY 10016
Phone: 212-263-5109
Fax: 212-263-0595
Email: daniel.rifkin@nyulangone.org

Administrative Contact

Marilyn Ajose
Program Associate
Phone: 212-263-8772
Fax: 212-263-5234
Email: marilyn.ajose@nyulangone.org