Metabolomics Laboratory Featured Publications

Coenzyme Q headgroup intermediates can ameliorate a mitochondrial encephalopathy

Shi, Guangbin; Miller, Claire; Kuno, Sota; Rey Hipolito, Alejandro G; El Nagar, Salsabiel; Riboldi, Giulietta M; Korn, Megan; Tran, Wyatt C; Wang, Zixuan; Ficaro, Lia; Lin, Tao; Spillier, Quentin; Gamallo-Lana, Begoña; Jones, Drew R; Snuderl, Matija; Song, Soomin C; Mar, Adam C; Joyner, Alexandra L; Sillitoe, Roy V; Banh, Robert S; Pacold, Michael E

Nature. 2025 Jul 09;

Microbial contribution to metabolic niche formation varies across the respiratory tract

Wong, Kendrew K; Wu, Benjamin G; Chung, Matthew; Li, Qinsheng; Darawshy, Fares; Tsay, Jun-Chieh J; Holub, Meredith; Barnett, Clea R; Kwok, Benjamin; Kugler, Matthias C; Chung, Cecilia; Natalini, Jake G; Singh, Shivani; Li, Yonghua; Schluger, Rosemary; Ficaro, Lia; Carpenito, Joseph; Collazo, Destiny; Perez, Luisanny; Kyeremateng, Yaa; Chang, Miao; Czachor, Anna; Singh, Raj; Mccormick, Colin; Campbell, Christina D; Keane, Ruaidhri; Askenazi, Manor; Hansbro, Philip M; Weiden, Michael D; Huang, Yvonne J; Stringer, Kathleen A; Clemente, Jose C; Li, Huilin; Jones, Drew; Ghedin, Elodie; Segal, Leopoldo N; Sulaiman, Imran

Cell host & microbe. 2025 Jul 09; 33:1073-1088.e6

Unravelling cysteine-deficiency-associated rapid weight loss

Varghese, Alan; Gusarov, Ivan; Gamallo-Lana, Begoña; Dolgonos, Daria; Mankan, Yatin; Shamovsky, Ilya; Phan, Mydia; Jones, Rebecca; Gomez-Jenkins, Maria; White, Eileen; Wang, Rui; Jones, Drew R; Papagiannakopoulos, Thales; Pacold, Michael E; Mar, Adam C; Littman, Dan R; Nudler, Evgeny

Nature. 2025 Jul ; 643:776-784

Addendum: Unravelling cysteine-deficiency-associated rapid weight loss

Varghese, Alan; Gusarov, Ivan; Gamallo-Lana, Begoña; Dolgonos, Daria; Mankan, Yatin; Shamovsky, Ilya; Phan, Mydia; Jones, Rebecca; Gomez-Jenkins, Maria; White, Eileen; Wang, Rui; Jones, Drew R; Papagiannakopoulos, Thales; Pacold, Michael E; Mar, Adam C; Littman, Dan R; Nudler, Evgeny

Nature. 2025 Jul ; 643:E16

Exploratory untargeted metabolomics analysis reveals differences in metabolite profiles in pregnant people exposed vs. unexposed to E-cigarettes secondhand in the NYU children's health and environment study

Cavalier, Haleigh; Long, Sara E; Rodrick, Tori; Siu, Yik; Jacobson, Melanie H; Afanasyeva, Yelena; Sherman, Scott; Liu, Mengling; Kahn, Linda G; Jones, Drew R; Trasande, Leonardo

Metabolomics. 2025 Jun 26; 21:92

Sex differences in mitochondrial free-carnitine levels in subjects at-risk and with Alzheimer's disease in two independent study cohorts

Bigio, Benedetta; Lima-Filho, Ricardo A S; Barnhill, Olivia; Sudo, Felipe K; Drummond, Claudia; Assunção, Naima; Vanderborght, Bart; Beasley, James; Young, Sarah; Korman, Aryeh; Jones, Drew R; Sultzer, David L; Ferreira, Sergio T; Mattos, Paulo; Head, Elizabeth; Tovar-Moll, Fernanda; De Felice, Fernanda G; Lourenco, Mychael V; Nasca, Carla

Molecular psychiatry. 2025 Jun ; 30:2573-2583

Correction: The intestinal microbiome and metabolome discern disease severity in cytotoxic T-lymphocyte-associated protein 4 deficiency

Chandrasekaran, Prabha; Krausz, Máté; Han, Yu; Mitsuiki, Noriko; Gabrysch, Annemarie; Nöltner, Christina; Proietti, Michele; Heller, Theo; Grou, Caroline; Calderon, Virginie; Subramanian, Poorani; Jones, Drew R; Siu, Yik; Deming, Clayton; Conlan, Sean; Holland, Steven M; Segre, Julia A; Uzel, Gulbu; Grimbacher, Bodo; Falcone, Emilia Liana

Microbiome. 2025 Mar 15; 13:74

The intestinal microbiome and metabolome discern disease severity in cytotoxic T-lymphocyte-associated protein 4 deficiency