Small Instrument Fleet Technologies
NYU Langone’s Small Instrument Fleet offers the following technologies.
StepOne Real-Time PCR System
The Applied Biosystems StepOne™ Real-Time PCR System is a 96-well polymerase chain reaction instrument that uses LED three-color optical recording to produce quantitative results. Intuitive data analysis software and advanced instrumentation allow our researchers to pursue genomic projects. Learn more about the Applied Biosystems StepOne™ Real-Time PCR System at Thermo Fisher Scientific’s website.
Touch Real-Time PCR Detection System
The Bio-Rad CFX96 and CFX384 Touch™ Real-Time PCR Detection Systems are six-channel systems featuring advanced optical technology with thermal control. Both deliver dependable data collection and quantitative polymerase chain reaction analysis. More information about the Bio-Rad CFX96 and CFX384 Touch™ is available at the Bio-Rad website.
Biorupter Sonication System
The Bioruptor®, made by Diagenode, is a sonication system that uniformly processes multiple samples in sealed tubes to avoid cross-contamination. Our researchers use this for shearing chromatin or DNA, cell lysis, and other applications. This instrument is in the Joan and Joel Smilow Research Center, no. 3 cold room. A recirculating water chiller and six-tube adaptor are available to our researchers. Learn more about the Bioruptor® at Diagenode’s website.
ChemiDoc Imaging System
The ChemiDoc™ Imaging System provides fast, reliable, and sensitive imaging and documentation of gels and chemiluminescence Western blots. This system is compatible with stain-free technology, chemiluminescence detection, and a wide range of gel stains such as ethidium bromide, SYPRO™ Ruby, Coomassie, and silver stains. Learn more about the ChemiDoc™ at Bio-Rad’s website.
Typhoon Trio Phosphoimaging System
The GE Typhoon Trio™ Phosphoimaging System uses three lasers to allow excitation and visualization of a wide wavelength range. Instrument applications can be used for analysis of fluorescent-stained protein gels, Western blots, and nucleic acid stains, as well as two-dimensional difference gel electrophoresis. Researchers use GE’s ImageQuant TL Software for data analysis. For more information about GE’s Typhoon Trio™, please see the user guide.
Odyssey Fc Imaging System
The Odyssey® Fc Imaging System, made by LI-COR, uses two channel near-infrared fluorescence to produce accurate digital images of DNA gels and Western blots. Researchers can simplify chemiluminescent imaging with limited instrument adjustments or multiple exposures. Image Studio™ software provides rapid analysis. More information about the Odyssey® Fc Imaging System is available on LI-COR’s website.
Odyssey Infrared Imaging System
The LI-COR Odyssey® Infrared Imaging System uses near-infrared fluorescence to provide a wide linear dynamic range and better sensitivity than chemiluminescence. The system can provide Western blot analysis, DNA gels, protein arrays, and many other applications. For more information about the LI-COR Odyssey® Infrared Imaging System, please see the Odyssey brochure.
FlexStation 3 Multi-Mode Microplate Reader
The FlexStation® 3 Multi-Mode Microplate Reader, made by Molecular Devices, is a benchtop device with numerous biochemical- and cell-based applications. The instrument can be used for fluorescence intensity, fluorescence polarization, time-resolved fluorescence, and luminescence assays. It uses SoftMax® Pro 7 Data Acquisition and Analysis Software. For more information about the FlexStation® 3 Multi-Mode Microplate Reader, please see the user guide.
Synergy H1 Multi-Mode Microplate Reader
The Synergy™ H1 is a configurable multimode microplate reader. You can choose monochromator-base optics for flexibility, filter-based optics for sensitivity, or both. BioTek’s patent Hybrid Technology™ offers high-performance and applications versatility in a modular platform to expand as your laboratory’s needs change. Top and bottom fluorescence intensity, UV-visible absorbance, and luminescence detection are available to meet many life science research requirements. Learn more about the Synergy™ H1 at BioTek’s website.
GenePix 4000B Microarray Scanner
The GenePix® 4000B Microarray Scanner includes advanced data analysis with GenePix® Pro Microarray Image Analysis Software and Acuity® Microarray Informatics Software. Researchers assess nucleic acid, protein, tissue, and cell microarrays. This imaging system uses two wavelengths to reduce scanning time and increase accuracy. Learn more about the GenePix®4000B Microarray Scanner at Molecular Devices’ website.
NanoDrop 8000 UV-Vis Spectrophotometer
The NanoDrop™ 8000 UV-Vis Spectrophotometer, made by Thermo Fisher Scientific, enables researchers to measure up to 8 microvolume protein and nucleic acid samples simultaneously and to evaluate the purity of samples as small as 1 μL. The NanoDrop™ 8000 comes with intuitive software for data analysis. Learn more about the NanoDrop™ 8000 UV-Vis Spectrophotometer at Thermo Fisher Scientific’s website.
LS 6500 Scintillation Counter
The Beckman LS 6500 Liquid Scintillation Counter is a high-performing system. The Beckman LS 6500 systems are equipped with a 32,678-channel analyzer that delivers an effective resolution of 0.06 keV for accurate results across a variety of samples. A patented H-Number Plus external quench monitor (H-Number Plus) fitted into the system provides accurate disintegrations per minute calculations and automatic quench compensation. Learn more about the LS 6500 Liquid Scintillation Counter.
Beta Counter MicroBeta2 System
The MicroBeta2 System provides advanced radiometric and luminescent detection abilities for GPCRs, kinases, reporter gene assays, and traditional liquid scintillation counting. Providing coincidence counting, a unique patented configuration with two photomultiplier tubes that simultaneously detect signal, the Microbeta2 System ensures high efficiency and extremely low background for a variety of radionuclides. Learn more about the MicroBeta2 System at PerkinElmer’s website.
WIZARD Automatic Gamma Counter
The next generation WIZARD® automatic gamma counter, Wizard2 is designed for superior counting performance with all types of samples and for every gamma counting application. Chromium release studies and nuclear medicine applications, such as PET research, are just some examples of possible gamma applications for Wizard2 instruments. Learn more about the Wizard2 1-Detector Gamma Counter at PerkinElmer’s website.
CellRad X-Ray Irradiator
The CellRad® X-Ray Irradiator by Faxitron is a dedicated cabinet X-ray cell irradiator designed for placement directly on the lab benchtop, arm’s-length from the incubator, eliminating the need to transport your cells to a core irradiation facility. The CellRad® System allows you to irradiate cells without compromising sterility or security and also serves as a smaller and more cost-effective alternative to gamma radioisotope and high-powered X-ray irradiators. Learn more about the CellRad® X-Ray Irradiator.
X-RAD 320 X-Ray Irradiator
The X-RAD 320 X-Ray Irradiator by Precision X-Ray is a self-contained X-ray system that delivers a precise radiation dosage to specimens in a biological or small animal research laboratory. The shielded cabinet includes an adjustable specimen shelf, sample viewing window, and beam hardening filter holder. The TouchRAD Control Panel is a multiuser, password-protected touch screen interface with a transportable database that can track individual system usage. Learn more about the X-Rad 320 X-Ray Irradiator.
MultiRad 350 X-Ray Irradiator
The MultiRad 350 X-Ray Irradiator by Faxitron is a compact, fully-integrated X-ray irradiation system that is a smaller, simpler, and safer alternative to radioisotope irradiators. The MultiRad was designed to deliver the highest dose with the most uniform beam profile while requiring the least amount of physics support. It is ideal for cells and small animals, as well as a broad range of industrial applications. Learn more about the MultiRad 350 X-Ray Irradiator.
X-Ray Film Developer
The Small Instrument Fleet offers dark rooms equipped with developers for the X-ray film processing. The film processor is designed to automate all steps: developing, rinsing, fixing, and washing and drying of the exposed film.