Vaccine Center Research | NYU Langone Health

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Vaccine Center Vaccine Center Research

Vaccine Center Research

Researchers at NYU Langone’s Vaccine Center use state-of-the-art methods to tackle complex problems in vaccine research. Our basic science and clinical research studies are designed to produce innovative new vaccines and devise ways to make their delivery painless and effective.

Around the world, communities are devastated by influenza, tuberculosis, malaria, and HIV/AIDS, conditions that are resistant to many existing drugs and targeted vaccines. Our challenge is to find new ways to combat these diseases and to identify safe, broadly effective vaccines that can make a powerful difference in global health.

We also focus on developing novel vaccines for nonviral and nonmicrobial illnesses including Alzheimer’s disease, autoimmune diseases, opioid use disorder, cancers, and other chronic conditions.

Beyond vaccine development, we lead research projects to develop new diagnostics and predictive markers to help providers detect disease early and predict the effectiveness of inoculation.

Active Studies

The Vaccine Center has two ongoing studies that support future vaccine trials and studies of the human immune system and infectious diseases. This research builds upon prior studies of the human immune response to infection and offers deeper insights into the complexity of these responses. It also holds possibilities for the development of rapid responses to emerging infectious threats. If you are interested in enrolling, please email nyuvaccinecenter@nyulangone.org.

Sample Collection for the Purpose of Evaluation and Validation of Immune Response and Microbiology Assays

This study aims to generate a biospecimen repository from human volunteers for the purpose of evaluation and validation of new immune response and microbiology assays.

Specimen Collection for Infectious Diseases with Public Health Importance

This study aims to generate a biospecimen repository from human volunteers with diseases of public health importance for the purpose of evaluation and validation of new assays.

Our Research Facilities

The Vaccine Center has basic research and clinical spaces in multiple NYU Langone research facilities. Our adaptable, modern spaces accommodate a range of research, including human challenge studies for diseases such as influenza, norovirus, and malaria.

Vaccine Center labs and clinical spaces are located in the following facilities:

  • NYU Langone Hospital—Brooklyn: inpatient research unit, controlled human infection models, pharmacokinetic/pharmacodynamics studies, and surge capacity for outpatient studies (public health emergency)
  • Schwartz Health Care Center: research clinic
  • Medical Science Building: specimen-processing laboratory and biospecimen repository
  • Alexandria Center for Life Sciences: research laboratories and administrative space

Recent Publications

Our investigators publish the results of their research in leading journals. Read their latest papers to learn more about our work.

Fc gamma receptor polymorphisms modulated the vaccine effect on HIV-1 risk in the HVTN 505 HIV vaccine trial

Li, Shuying S; Gilbert, Peter B; Carpp, Lindsay N; Pyo, Chul-Woo; Janes, Holly; Fong, Youyi; Shen, Xiaoying; Neidich, Scott D; Goodman, Derrick; deCamp, Allan; Cohen, Kristen W; Ferrari, Guido; Hammer, Scott M; Sobieszczyk, Magdalena E; Mulligan, Mark J; Buchbinder, Susan P; Keefer, Michael C; DeJesus, Edwin; Novak, Richard M; Frank, Ian; McElrath, M Juliana; Tomaras, Georgia D; Geraghty, Daniel E; Peng, Xinxia

Journal of virology. 2019 Nov 01; 93:

Mycobacterium tuberculosis Rv2700 Contributes to Cell Envelope Integrity and Virulence

Ballister, Edward R; Samanovic, Marie I; Darwin, K Heran

Journal of bacteriology. 2019 Oct 01; 201:

The Prevotella copri Complex Comprises Four Distinct Clades Underrepresented in Westernized Populations

Tett, Adrian; Huang, Kun D; Asnicar, Francesco; Fehlner-Peach, Hannah; Pasolli, Edoardo; Karcher, Nicolai; Armanini, Federica; Manghi, Paolo; Bonham, Kevin; Zolfo, Moreno; De Filippis, Francesca; Magnabosco, Cara; Bonneau, Richard; Lusingu, John; Amuasi, John; Reinhard, Karl; Rattei, Thomas; Boulund, Fredrik; Engstrand, Lars; Zink, Albert; Collado, Maria Carmen; Littman, Dan R; Eibach, Daniel; Ercolini, Danilo; Rota-Stabelli, Omar; Huttenhower, Curtis; Maixner, Frank; Segata, Nicola

Cell host & microbe. 2019 Sep 24;

Decreased humoral immunity to mumps in young adults immunized with MMR vaccine in childhood

Rasheed, Mohammed Ata Ur; Hickman, Carole J; McGrew, Marcia; Sowers, Sun Bae; Mercader, Sara; Hopkins, Amy; Grimes, Vickie; Yu, Tianwei; Wrammert, Jens; Mulligan, Mark J; Bellini, William J; Rota, Paul A; Orenstein, Walter A; Ahmed, Rafi; Edupuganti, Srilatha

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2019 Sep 03;

Thioesterase PPT1 balances viral resistance and efficient T cell crosspriming in dendritic cells

Ou, Pengju; Wen, Lifen; Liu, Xiaoli; Huang, Jiancheng; Huang, Xiaoling; Su, Chaofei; Wang, Ling; Ni, Hai; Reizis, Boris; Yang, Cliff Y

Journal of experimental medicine. 2019 Sep 02; 216:2091-2112

A Phase 1b Trial to Evaluate the Safety and Pharmacokinetics of Multiple Ascending Doses of Filociclovir (MBX-400, Cyclopropavir) in Healthy Volunteers

Rouphael, Nadine G; Hurwitz, Selwyn J; Hart, Mari; Beck, Allison; Anderson, Evan J; Deye, Gregory; Osborn, Blaire; Cai, Shu Yi; Focht, Chris; Amegashie, Cyrille; Bowlin, Terry L; Brooks, Jennifer; Mulligan, Mark J

Antimicrobial agents & chemotherapy. 2019 Sep ; 63:

Distribution of Late-Onset Neonatal Sepsis Pathogens Differs in Inpatient and Outpatient Settings

Black, Celeste G; Tavares, Larissa; Stachel, Anna; Ratner, Adam J; Randis, Tara M

American journal of perinatology. 2019 Sep ; 36:1136-1141

Gardnerella and Prevotella: Co-conspirators in the Pathogenesis of Bacterial Vaginosis

Randis, Tara M; Ratner, Adam J

Journal of infectious diseases. 2019 Aug 30; 220:1085-1088